Results 141 to 150 of about 70,011 (259)
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Obsessive–compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance. Converging evidence implicates glutamatergic dysregulation in OCD pathophysiology.
Ahmad Zolghadriha +2 more
wiley +1 more source
Artificial sensory and motor nervous systems enabled by bioinspired nanowire heterostructure synapse
InfoMat, Volume 8, Issue 5, May 2026.A p‐i‐n heterostructured junction synaptic transistor was fabricated, composed of poly(3‐hexylthiophene‐2,5‐diyl) nanowire thin‐film/poly(methyl methacrylate)/ZnO nanowires (PZJ STs), which can emulate biological sensory and motor nervous systems.
Lu Yang +7 more
wiley +1 more source
Placental‐Derived Connective Tissue Matrix Mediates Murine Recurrent Laryngeal Nerve Regeneration
The Laryngoscope, Volume 136, Issue 5, Page 2220-2231, May 2026.Placentally derived connective tissue matrix (pd‐CTM) innately contains various neurotrophic, angiogenic, anti‐inflammatory, and tissue remodeling cytokines. In this mouse model of unilateral vocal fold paralysis, we investigate its effects on recurrent laryngeal nerve (RLN) regeneration and reinnervation of the right thyroarytenoid (TA) muscle after ...
Sunjay Anekal +7 more
wiley +1 more source
Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian +3 more
wiley +1 more source
Allergy, Volume 81, Issue 5, Page 1617-1634, May 2026.This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng +20 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1
British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim +10 more
wiley +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
European Journal of Neuroscience, Volume 63, Issue 9, May 2026.This work provides a potential new link between the anticonvulsive Topiramate, the deacetylase Sirt‐1 and the cholinergic signalling, suggesting that Topiramate may modulate cholinergic pathways in a Sirt‐1 depended manner. ABSTRACT Although some forms of epilepsy directly result from mutations in nicotinic acetylcholine receptors, none of the ...
Marie‐Luise Kümmel
wiley +1 more source
Review: “The Disappointment Dilemma: Short‐ and Long‐Term Learning From Negative Outcomes”
European Journal of Neuroscience, Volume 63, Issue 9, May 2026.The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ines Ibañez‐Tallon +4 more
wiley +1 more source