Results 141 to 150 of about 1,317,031 (279)

Anion Conducting States of Excitatory Amino Acid Transporters [PDF]

, 2013
Excitatory amino acid transporters (EAATs) are secondary active, electrogenic transporters which translocate L-glutamate (glu) against its concentration gradient using the co-transport of 3 Na+, 1 H+, and the counter-transport of 1 K+ ion.
Divito, Christopher B.
core  

The actions of muscle relaxants at nicotinic acetylcholine receptor isoforms

, 1998
The pharmacological diversity of the different isoforms of the nicotinic acetylcholine receptor arises from the diversity of the subunits that assemble to form the native receptors.
Robert J. Walker, Lindy Holden-Dye, Walker, R.J., Foreman, R.C., Holden-Dye, L., Chad, J.E., Catherine M. Garland, Garland, C.M., Richard C. Foreman, John E. Chad   +9 more
core   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Imidacloprid Alters Activity and Responses to a Visual Predator Stimulus in Aussie Bronze Jumping Spiders (Helpis minitabunda, Araneae, Salticidae)

Ethology, EarlyView.
A field‐recommended concentration of a commercial imidacloprid formulation reduced open arena activity and slowed climbing in the jumping spider Helpis minitabunda. Exposed spiders still detected a looming predator stimulus, but their responses were reduced.
Reshnu Rajan‐Sheela, Gregory I. Holwell, Anne Wignall   +2 more
wiley   +1 more source

The Interactions Between Acetylcholine and T‐Cells and Their Role in the Immune System: A Scoping Review

Immunology, EarlyView.
Activated T‐cells instigate signalling events leading to the activation of transcription factors, which in turn, act on the nucleus to produce cytokines. We postulate that c‐fos is one of these transcription factors which upregulates the choline acetyltransferase gene responsible for synthesising acetylcholine (ACh).
Jarita Lay, Nicholas Manolios
wiley   +1 more source

Molecular characterisation of insect nicotinic acetylcholine receptors [PDF]

, 2003
Nicotinic acetylcholine receptors (nAChRs) are pentameric multi-subunit proteins that form ligand-gated ion channels in the central nervous systems of vertebrates and invertebrates and at the neuromuscular junction of vertebrate species. In insects, they
Kirwan, M. J., Kirwan, Michael Joseph
core  

Molecular characterization and imidacloprid selectivity of nicotinic acetylcholine receptor subunits from the peach-potato aphid Myzus persicae

, 1999
The recent introduction of the chloronicotinyl insecticide imidacloprid, targeting insect nicotinic acetylcholine receptors (nAChRs), emphasises the importance of a detailed molecular characterisation of these receptors.
Millar, N. S., Wllliamson, M. S., Huang, Y., Landsell, S. J., Devonshire, A. L., Windass, J. D.   +5 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Association of Neonicotinoid insensitivity with a conserved residue in the Loop D binding region of the Tick Nicotinic Acetylcholine Receptor

, 2012
Neonicotinoid insecticides target nicotinic acetylcholine receptors (nAChR) in the nervous system of insects but are largely ineffective against ticks. This study aimed to identify the molecular basis for this insensitivity. A homology model of the nAChR
O’Reilly, Andrias O., Field, L.M., Erdmanis, L., Field, L. M., Williamson, M.S., Wallace, Bonnie A., O'Reilly, A. O., Wallace, B. A., Turberg, A., Williamson, M. S.   +9 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source