Results 171 to 180 of about 42,864 (300)

Advances in PET Imaging of α7 Nicotinic Receptors: From Radioligand Development to CNS Applications

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 4, April 2025.
ABSTRACT Positron emission tomography (PET) has significantly advanced our understanding of the brain by enabling non‐invasive imaging and quantification of molecular processes, including receptor binding. In this review, we explore the development and application of PET radioligands targeting the α7 nicotinic acetylcholine receptor (α7 nAChR), a ...
Janus H. Magnussen
wiley   +1 more source

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition. [PDF]

Nat Commun
Su J, Yu Z, Yin Z, Zhang Z, Zhao J, Meng Y, Li R, Gao Y, Zhang H, Yu R, Zhao Y.   +10 more
europepmc   +1 more source

Phosphorylation and assembly of nicotinic acetylcholine receptor subunits in cultured chick muscle cells.

, 1987
A F Ross, M Rapuano, J H Schmidt, Joav Prives   +3 more
openalex   +1 more source

Comparison of innervation and agrin-induced tyrosine phosphorylation of the nicotinic acetylcholine receptor [PDF]

, 1994
Zhihui Qu, RL Huganir
openalex   +1 more source

Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline

British Journal of Pharmacology, Volume 182, Issue 7, Page 1466-1486, April 2025.
Background and Purpose Alterations in tryptophan‐kynurenine (TRP‐KYN) pathway are implicated in major depressive disorder (MDD). α7 nicotinic acetylcholine (α7nACh) receptor regulates the hypothalamic–pituitary–adrenal (HPA) axis. We have shown that deficiency of kynurenine 3‐monooxygenase (KMO) induces depression‐like behaviour via kynurenic acid ...
Masaya Hasegawa, Kazuo Kunisawa, Bolati Wulaer, Hisayoshi Kubota, Hitomi Kurahashi, Takatoshi Sakata, Honomi Ando, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Taku Nagai, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression. [PDF]

Front Cell Dev Biol
Cai J, Wang J, Wang Z, Wang J, Jia Y, Ma X.   +5 more
europepmc   +1 more source

Ca2+-dependent and cAMP-dependent Control of Nicotinic Acetylcholine Receptor Phosphorylation in Muscle Cells

, 1989
McHardy M. Smith, John P. Merlie, John C. Lawrence   +2 more
openalex   +1 more source

The I-Abm12 mutation, which confers resistance to experimental myasthenia gravis, drastically affects the epitope repertoire of murine CD4+ cells sensitized to nicotinic acetylcholine receptor. [PDF]

, 1991
Matteo Bellone, Norma Ostlie, S. Lei, Xiadong Wu, Bianca M. Conti‐Tronconi   +4 more
openalex   +1 more source

Ghrelin: An Emerging Therapy for Heart Failure

Clinical Endocrinology, Volume 102, Issue 4, Page 403-412, April 2025.
ABSTRACT Objective Ghrelin is emerging as a promising therapeutic option for heart failure (HF) due to its potent inotropic, anabolic, and cardioprotective properties. This review aims to critically examine the available clinical evidence on ghrelin therapy in HF, while also incorporating key findings from preclinical studies that support its ...
Nikolaos Theodorakis, Georgios Feretzakis, Magdalini Kreouzi, Dimitrios Anagnostou, Christos Hitas, Vassilios S. Verykios, Maria Nikolaou   +6 more
wiley   +1 more source

Human α10 nicotinic acetylcholine receptor subunits assemble to form functional receptors. [PDF]

J Biol Chem
Tekarli B, Azam L, Hone AJ, McIntosh JM.
europepmc   +1 more source