MedComm, Volume 6, Issue 12, December 2025.Schematic illustration of the roles of CIP2A and RING1 in lung tumorigenesis Accumulation of DNMT1 due to NNK exposure leads to a reduction in RING1 mRNA levels. Decreased RING1 results in an accumulation of CIP2A protein levels and upregulated CIP2A suppresses PP2A activity, consequently increasing the stability of c‐MYC.
In‐ho Jeong +4 more
wiley +1 more source
Characterisation of an unusual nicotinic acetylcholine receptor subtype preferentially sensitive to biogenic amines. [PDF]
Commun BiolMitchell EL +6 more
europepmc +1 more source
Identification of N-terminal Extracellular Domain Determinants in Nicotinic Acetylcholine Receptor (nAChR) α6 Subunits That Influence Effects of Wild-type or Mutant β3 Subunits on Function of α6β2*- or α6β4*-nAChR [PDF]
, 2011 Bhagirathi Dash +3 more
openalex +1 more source
Med Research, Volume 1, Issue 3, Page 322-358, December 2025.ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin +8 more
wiley +1 more source
Nicotinic Acetylcholine Receptor Pathways in Cancer: From Psychiatric Clues to Therapeutic Opportunities. [PDF]
Cancer Rep (Hoboken)Azadi MH +3 more
europepmc +1 more source
Glycine Reverses Behavioral Deficits in a Mouse Model for Psychosis With 4 Copies of the Gldc Gene
Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.Mice with 4 copies of the glycine decarboxylase (Gldc) gene display startle habituation deficits, which are reversed by treatment with glycine. In control‐treated wild type mice (A), the response to the last startle stimuli is lower than the response to the first startle stimuli. In control‐treated mice with 4 copies of the 9p24.1 genes including Gldc (
Muxiao Wang +4 more
wiley +1 more source
The Human Alpha3 Beta2 Neuronal Nicotinic Acetylcholine Receptor Can Form Two Distinguishable Subtypes. [PDF]
Int J Mol SciJackson DC, Hall MK, Sudweeks SN.
europepmc +1 more source
Recent Advances in Stereospecific Transformations of Organoboron Reagents
Transformative Chemistry, Volume 1, Issue 1, December 2025.Enantioenriched boronic esters when activated with organolithiums, can be transformed into boronate complexes that act as chiral organometallic‐type nucleophiles and can engage a wide variety of electrophiles in stereospecific cross‐coupling reactions.
Shubham Ojha +3 more
wiley +1 more source
Development of a novel alpha7-nicotinic acetylcholine receptor-selective cell-penetrating peptide for intracellular cargo transport. [PDF]
Drug DelivWeber L, O'Brien BCV, Weltzin MM.
europepmc +1 more source