Results 21 to 30 of about 144,075 (368)
Neuregulin upregulates microglial α7 nicotinic acetylcholine receptor expression in immortalized cell lines: implications for regulating neuroinflammation. [PDF]
PLoS ONE, 2013 Neuregulin, previously known as ARIA, is a signaling protein involved in cell survival, synaptic plasticity, cell communication and differentiation. Neuregulin has also been described as a potent inducer of acetylcholine receptor transcription in muscle ...
Malwina Mencel +2 more
doaj +1 more source
Journal of Pharmacological Sciences, 2010 We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor
Yuki Takada-Takatori +6 more
doaj +1 more source
Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]
, 2009 Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan +4 more
core +1 more source
The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor
Pharmacological Research, 2023 Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic receptors (nAChRs) were classically identified to mediate synaptic transmission in the nervous system and the neuromuscular junction. The α9 and α10 nAChR subunits were
Ana Belén Elgoyhen
doaj +1 more source
Activation of a nicotinic acetylcholine receptor
Biophysical Journal, 1984 We studied activation of the nicotinic acetylcholine (ACh) receptor on cells of a mouse clonal muscle cell line (BC3H1). We analyzed single-channel currents through outside-out patches elicited with various concentrations of acetylcholine (ACh), carbamylcholine (Carb) and suberyldicholine (Sub).
Joe Henry Steinbach, Steven M. Sine
openaire +2 more sources
Toxics, 2018 Among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic ...
Anna Maria Lavezzi
doaj +1 more source
Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
N. Abraham, R. Lewis
semanticscholar +1 more source
The distribution of charged amino acid residues and the Ca(2+) permeability of nicotinic acetylcholine receptors: a predictive model [PDF]
, 2017 Nicotinic acetylcholine receptors (nAChRs) are cation-selective ligand-gated ion channels exhibiting variable Ca(2+) permeability depending on their subunit composition.
Fucile, Sergio
core +1 more source
Vagus nerve stimulation is a potential treatment for ischemic stroke
Neural Regeneration Research, 2023 Microglia are the brain’s primary innate immune cells, and they are activated and affect pro-inflammatory phenotype or regulatory phenotype after ischemic stroke.
Yi-Lin Liu +4 more
doaj +1 more source
Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
Nature Communications, 2016 Allergic asthma is a complex and chronic inflammatory disorder that is associated with airway hyperreactivity (AHR) and driven by Th2 cytokine secretion.
Lauriane Galle-Treger +7 more
semanticscholar +1 more source