Results 101 to 110 of about 140,109 (356)
Frontiers in Molecular Neuroscience, 2012 Addictive drugs can activate systems involved in normal reward-related learning, creating long-lasting memories of the drug's reinforcing effects and the environmental cues surrounding the experience.
A. Feduccia +2 more
semanticscholar +1 more source
Mass Spectrometry Reviews, EarlyView.Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley +1 more source
Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]
, 2016 Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core +1 more source
Glutamatergic Synapse Formation is Promoted by α7-Containing Nicotinic Acetylcholine Receptors
Journal of Neuroscience, 2012 Glutamate is the primary excitatory transmitter in adult brain, acting through synapses on dendritic spines and shafts. Early in development, however, when glutamatergic synapses are only beginning to form, nicotinic cholinergic excitation is already ...
A. Lozada +6 more
semanticscholar +1 more source
Management of Anxiety in Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.ABSTRACT Background Anxiety is a common, distressing, hard‐to‐diagnose and hard‐to‐treat symptom in Parkinson's disease. No formal guidelines exist to assist management. Objective We provide a pragmatic guide to detecting and managing anxiety in Parkinson's disease.
Alex J. Berry +4 more
wiley +1 more source
Nicotine : Pharmacology and therapeutic implications in neurodegenerative and psychiatric disorders [PDF]
, 2005 The pathophysiology of tobacco-related diseases is complex and multifactorial. Among the various compounds in tobacco smoke are carcinogens such as nitrosamines, irritants such as a variety of phenolic compounds, volatiles such as carbon monoxide, and of
Scerri, Charles
core
Cholinergic modulation of dopamine overflow in the rat neostriatum: A fast cyclic voltammetric study in vitro [PDF]
, 1994 Stimulus-evoked dopamine overflow in rat neostriatal slices was determined using fast cyclic voltammetry. The dopamine efflux induced by intrastriatal stimulation increased with stimulus intensity and was found to be enhanced by more than 100% upon ...
Kudernatsch, Martina, Sutor, Bernd
core +1 more source
Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou +6 more
wiley +1 more source
Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells [PDF]
, 2016 In addition to the T2R bitter taste receptors, neuronal nicotinic acetylcholine receptors (nAChRs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol.
Alkahtan, Reem M. +6 more
core +3 more sources
Regulation of Nicotinic Acetylcholine Receptor Assembly
Annals of the New York Academy of Sciences, 2003 Abstract: The four muscle‐type nicotinic acetylcholine receptor (AChR) subunits, α, β, γ, and δ, assemble into functional α2βγδ pentamers in the endoplasmic reticulum (ER) through a series of interdependent folding and oligomerization events. The first stable assembly intermediate is a trimer composed of α, β, and γ subunits.
Wanamaker, C, Christianson, J, Green, W
openaire +3 more sources