Results 151 to 160 of about 43,248 (261)

Significance of nicotine and nicotinic acetylcholine receptors in Parkinson's disease. [PDF]

Front Aging Neurosci
Lin X, Li Q, Pu M, Dong H, Zhang Q.
europepmc   +1 more source

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji, Ehud Karavani, Michael Danziger, Pengyue Zhang, Yuan Hou, Yadi Zhou, Marina Bykova, Andrew A. Pieper, Michal Rosen‐Zvi, Jeffrey Cummings, Feixiong Cheng   +10 more
wiley   +1 more source

Dual Agonist/Antagonist Modulation of α9-Containing Nicotinic Acetylcholine Receptors by 2-Ammoniumethyl Ethers of Stilbenol and Stilbenol Analogues. [PDF]

J Med Chem
Giraudo A, Tae HS, Hung A, Richter K, Shivankar B, Armano E, Grau V, Pallavicini M, Adams DJ, Bolchi C.   +9 more
europepmc   +1 more source

Inhibition of nicotinic acetylcholine receptors by oligoarginine peptides and polyamine-related compounds. [PDF]

Front Pharmacol, 2023
Ojomoko LO, Kryukova EV, Egorova NS, Salikhov AI, Epifanova LA, Denisova DA, Khomutov AR, Sukhov DA, Vassilevski AA, Khomutov MA, Tsetlin VI, Shelukhina IV.   +11 more
europepmc   +1 more source

Use of Acetylcholine Binding Protein in the Search for Novel α7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-ray Analysis

, 2009
Chris Ulens, Atilla Akdemir, Aldo Jongejan, René van Elk, Sonia Bertrand, Anastassis Perrakis, Rob Leurs, August B. Smit, Titia K. Sixma, Daniel Bertrand, Iwan J. P. de Esch   +10 more
openalex   +2 more sources

The NMDA Receptor Antagonist Memantine Modulates Aging and Stress Resilience

Aging Cell, Volume 25, Issue 1, January 2026.
Memantine, an NMDA receptor antagonist, extends lifespan and enhances stress resilience in C. elegans through caloric restriction–like metabolic adaptations, including reduced oxidative stress and increased fatty acid β‐oxidation, revealing a conserved mechanism linking glutamatergic signaling to healthy aging.
Vaida Juozaityte, Chiara Pregnolato, Steffen Abay‐Nørgaard, Dylan Matthew Rausch, Rebecca L. McIntyre, Zachary Gerhart‐Hines, Tune H. Pers, Anna Elisabetta Salcini, Christoffer Clemmensen   +8 more
wiley   +1 more source

The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors. [PDF]

Front Immunol
Wolf PMK, Hanke D, Singh VK, Keller HL, Ettischer LJ, Teppe L, Amati AL, Hecker A, Husain-Syed F, Rohde M, Nuber UA, Büttner K, McIntosh JM, Liese J, Mazurek S, Grau V, Richter K.   +16 more
europepmc   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer's Disease Pathophysiology. [PDF]

Life (Basel)
Rennie K.
europepmc   +1 more source

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source