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Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors [PDF]

Current Neuropharmacology, 2018
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are involved in a variety of ...
Cecilia Gotti, Michele Zoli, Antonietta Vilella   +2 more
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Nicotinic Acetylcholine Receptors and Imaging

Current Pharmaceutical Design, 2000
In vivo imaging techniques like positron emission tomography (PET) and single photon emission computed tomography (SPECT) offer the possibility to monitor human central nicotinic acetylcholine receptors (nAChRs) in a variety of central nervous system disorders. In the past, the only available PET radiotracer for imaging nAChRs in the human brain, [11C]-
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Nicotinic Acetylcholine Receptor Assays

Current Protocols in Pharmacology, 1999
AbstractNicotinic acetylcholine receptors (nAChRs) in peripheral tissues are localized almost exclusively to autonomic nerves and the motor end plates of striated musculature. Pharmacologic analyses of nicotinic receptor antagonist potencies can be conducted by assessing the ability of these compounds to inhibit responses elicited by preganglionic ...
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Nicotinic Acetylcholine Receptors and Epilepsy

Current Drug Target -CNS & Neurological Disorders, 2002
The neuronal nicotinic acetylcholine receptors (nAChRs) have multiple roles in the brain: they are involved in signal transduction by fast synaptic transmission, axo-axonic transmission, and in the modulation of presynaptic transmitter release. Presynaptic nAChRs can increase the release of excitatory as well as of inhibitory transmitters, and can ...
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Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
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Neuronal Nicotinic Acetylcholine Receptors

1996
Studies of the structure and function of neuronal nicotinic acetylcholine receptors (AChRs) evolved out of studies of muscle AChRs. This review will begin with a brief summary of muscle type AChRs because they are the archetype for studies of neuronal nicotinic AChRs in particular and ligand-gated ion channels in general.
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The paradox of nicotinic acetylcholine receptor upregulation by nicotine

Trends in Pharmacological Sciences, 1990
Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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Immunology of the Nicotinic Acetylcholine Receptor

1979
The classical surface antigens of Enterobacteriaceae: 0, K, and H antigens have been studied extensively in the past and have provided a basis for the taxonomy of this family (Kauffmann, 1966, 1975). In comparison to the vast knowledge accumulated on the structure, localization, genetic determination, and biologic effects of O and K antigens (Weinbaum ...
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Nicotinic acetylcholine receptors in the brain

The nicotinic acetylcholine receptor (nAChR) is the archetypal neurotransmitter receptor within the superfamily of pentameric ligand-gated ion channels (pLGICs). Typically, it mediates fast synaptic transmission in response to its endogenous ligand, acetylcholine, and can also intervene in slower signaling mechanisms via intracellular metabolic ...
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Protein Phosphorylation of Nicotinic Acetylcholine Receptor

Critical Reviews in Biochemistry and Molecular Biology, 1989
The nicotinic acetylcholine receptor (nAcChR) is a ligand-gated ion channel found in the postsynaptic membranes of electric organs, at the neuromuscular junction, and at nicotinic cholinergic synapses of the mammalian central and peripheral nervous system.
R L, Huganir, K, Miles
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