Results 181 to 190 of about 141,837 (296)

Engineering exosomes for Alzheimer's disease: Multi‐target therapeutic strategies from pathogenesis to clinical translation

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
Exosomes, modified through multidimensional approaches including physical, chemical and genetic means, and equipped with brain‐targeted peptides and therapeutic agents, are capable of crossing the blood‒brain barrier for precise delivery. They can simultaneously remove amyloid‐beta plaques and neurofibrillary tangle, inhibit neuroinflammation, and pave
Yuehan Zhang, Zhenyang Li, Haien Guan, Zhenhua Qiu, Chunlin Zou   +4 more
wiley   +1 more source

Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer’s dementia [PDF]

, 2018
Osama Sabri, Philipp Meyer, Susanne Gräf, Swen Hesse, Stephan Wilke, Georg‐Alexander Becker, Michael Rullmann, Marianne Patt, Julia Luthardt, Gudrun Wagenknecht, Alexander Hoepping, René Smits, Annegret Franke, Bernhard Sattler, Solveig Tiepolt, Steffen Fischer, Winnie Deuther‐Conrad, Ulrich Hegerl, Henryk Barthel, Peter Schönknecht, Peter Brust   +20 more
openalex   +1 more source

Cannabidiol as a Neuroprotective Agent in Acrylamide‐Induced Neurotoxicity: Effects on Oxidative Stress, Inflammation, and Cholinergic Function in Male Mice

Journal of Neuroscience Research, Volume 103, Issue 12, December 2025.
Cannabidiol (CBD) protects against acrylamide‐induced neurotoxicity in mice by reducing oxidative stress, inflammation, and cholinergic dysfunction, while restoring BDNF levels. These findings highlight CBD's potential as a therapeutic agent for preventing environmental neurotoxicity and supporting brain health.
Korina Atsopardi, Konstantinos Mesiakaris, Ioannis Sotiropoulos, Marigoula Margarity, Konstantinos Poulas   +4 more
wiley   +1 more source

The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance in Mice by Restoring Hyperoxia-Compromised Macrophage Function [PDF]

, 2014
Ravikumar Sitapara, Daniel J. Antoine, Lokesh Sharma, Vivek Patel, Charles R. Ashby, Samir Gorasiya, Huan Yang, Michelle Zur, Lin L. Mantell   +8 more
openalex   +1 more source

The Transgenerational Link: Breeder Gut Microbiota and Broiler Progeny Development

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The breeder hen gut microbiome, shaped by maternal factors and targeted nutrition, drives reproductive performance and transmits beneficial microbes that programme gut health, immunity, and growth in progeny. Microbiome‐focused interventions can optimise egg quality, hatchability, progeny performance, and sustainability in poultry production.
Gladys Maria Pangga, Stephen Bamford, Anne Richmond, Nicolae Corcionivoschi, Umer Zeeshan Ijaz, Ozan Gundogdu   +5 more
wiley   +1 more source

Stimulation of the α7 Nicotinic Acetylcholine Receptor Protects against Neuroinflammation after Tibia Fracture and Endotoxemia in Mice [PDF]

, 2014
Niccolò Terrando, Ting Yang, Jae Kyu Ryu, Phillip T. Newton, Claudia Monaco, Marc Feldmann, Daqing Ma, Katerina Akassoglou, Mervyn Maze   +8 more
openalex   +1 more source

Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking‐Induced Lung Tumorigenesis

MedComm, Volume 6, Issue 12, December 2025.
Schematic illustration of the roles of CIP2A and RING1 in lung tumorigenesis Accumulation of DNMT1 due to NNK exposure leads to a reduction in RING1 mRNA levels. Decreased RING1 results in an accumulation of CIP2A protein levels and upregulated CIP2A suppresses PP2A activity, consequently increasing the stability of c‐MYC.
In‐ho Jeong, Jae Kwang Yun, Jun‐O. Jin, Geun Dong Lee, Peter Chang‐Whan Lee   +4 more
wiley   +1 more source

Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction. [PDF]

Front Neurosci
Jiang J, Li X, Hu AF, Zhou GJ, Gao YH, Xu C, Wu XM, Wang HJ.   +7 more
europepmc   +1 more source

Identification of N-terminal Extracellular Domain Determinants in Nicotinic Acetylcholine Receptor (nAChR) α6 Subunits That Influence Effects of Wild-type or Mutant β3 Subunits on Function of α6β2*- or α6β4*-nAChR [PDF]

, 2011
Bhagirathi Dash, Minoti Bhakta, Yongchang Chang, Ronald J. Lukas   +3 more
openalex   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li, Fangfang Li, Yang Tang, Siyu Guo, Yihan Yao, Yuan Fang, Bicheng Zhang, Yu Jiang, Jing Wang, Dang Wu, Jianxia Cheng, Zhihui Huang, Zengfeng Xin, Ting Zhang   +13 more
wiley   +1 more source