Results 181 to 190 of about 139,940 (327)

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
James Melrose, Stone Sima, Neha Chopra, Ashish Diwan, Zi Gu   +4 more
wiley   +1 more source

The I-Abm12 mutation, which confers resistance to experimental myasthenia gravis, drastically affects the epitope repertoire of murine CD4+ cells sensitized to nicotinic acetylcholine receptor. [PDF]

, 1991
Matteo Bellone, Norma Ostlie, S. Lei, Xiadong Wu, Bianca M. Conti‐Tronconi   +4 more
openalex   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, Volume 44, Issue 5, Page 715-756, September/October 2025.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice

Nature Communications
Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen, Peter M. Klein, Cheng Xie, Katelyn N. Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T. Bendor, Barna Dudok, Jordan S. Farrell, Tilo Gschwind, Charlotte L. Porter, Annahita Keravala, G. Steven Dodson, Ivan Soltesz   +13 more
doaj   +1 more source

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors

Pharmacological Reviews, 2015
D. Bertrand, Chih-Hung Lee, D. Flood, Fabrice Marger, D. Donnelly‐Roberts   +4 more
semanticscholar   +1 more source

Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy

MedComm, Volume 6, Issue 9, September 2025.
The pancreatic islets, composed of α, β, δ, ε, and PP cells, play a central role in maintaining glucose homeostasis. This review examines the mechanisms of islet hormone secretion and their functional crosstalk networks, alongside the pathophysiology of diabetes driven by hormonal dysregulation.
Jinfang Ma, Mao Li, Lingxiao Yang, Qingxing Xie, Rongping Fan, Xi Lu, Xing Huang, Nanwei Tong, Zhenyu Duan   +8 more
wiley   +1 more source

Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors

Anais da Academia Brasileira de Ciências, 2002
Several neurotransmitter systems have been related to developmental processes during the past decade. In this review, we discuss the evidence that the nicotinic acetylcholine receptors could have an additional function during development that may be ...
TORRÃO ANDRÉA S., BRITTO LUIZ R.G.
doaj  

Inhibition of nicotinic acetylcholine receptors by oligoarginine peptides and polyamine-related compounds. [PDF]

Front Pharmacol, 2023
Ojomoko LO, Kryukova EV, Egorova NS, Salikhov AI, Epifanova LA, Denisova DA, Khomutov AR, Sukhov DA, Vassilevski AA, Khomutov MA, Tsetlin VI, Shelukhina IV.   +11 more
europepmc   +1 more source

Determination of the sites of cAMP-dependent phosphorylation on the nicotinic acetylcholine receptor.

, 1987
GH Yee, RL Huganir
openalex   +1 more source

Implications of Tobacco Use on Pathogen‐Driven Diseases: A Public Health and Policy Perspective

World Medical &Health Policy, Volume 17, Issue 3, Page 468-474, September 2025.
ABSTRACT The tobacco epidemic remains one of the most significant global public health challenges, responsible for over 8 million deaths annually, with a substantial portion occurring among non‐smokers exposed to second‐hand smoke. While cigarette smoking remains the most prevalent form of tobacco use worldwide, the rise of electronic nicotine delivery
Nadine Kabbani, James L. Olds
wiley   +1 more source