Results 231 to 240 of about 140,109 (356)

Mitochondria‐Homing Drug Mitochonic Acid 5 Improves Barth Syndrome Myopathy in a Human‐Induced Pluripotent Stem Cell Model and Barth Syndrome Drosophila Model

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Barth syndrome (BTHS) is a rare disease caused by mutations in the tafazzin gene that affects the heart and muscles, but till date, no clinically effective drugs. Using Barth syndrome myopathy in human‐ iPS‐derived disease cells and Drosophila melanogaster model, a new mitochondria‐homing drug MA‐5, improves BTHS dysfunction and may serve as a new ...
Yoshiyasu Tongu, Tomoko Kasahara, Tetsuro Matsuhashi, Yoshitsugu Oikawa, Ryota Akimoto, Yuhan Luo, Sayaka Sekine, Momoka Suzuki, Hitomi Kashiwagi, Shinichiro Kanno, Yoshikazu Tanaka, Kyohei Sato, Yusuke Okubo, Akihiko Muto, Hidetaka Tokuno, Chitose Suzuki, Chiharu Kawabe, Takamasa Ishikawa, Shun Watanabe, Koichi Kikuchi, Shun Itai, Takeya Sato, Takehiro Suzuki, Kazuhiro Igarashi, Shinji Fukuda, Tomoyoshi Soga, Kei Murayama, Erina Kuranaga, Takafumi Toyohara, Takaaki Abe   +29 more
wiley   +1 more source

Competitive Antagonism of Xylazine on α7 Nicotinic Acetylcholine Receptors and Reversal by Curcuminoids. [PDF]

ACS Chem Neurosci
Chen Q, Xu Y, Tang P.
europepmc   +1 more source

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

, 1990
Mario DiPaola, Peter N. Kao, Arthur Karlin   +2 more
openalex   +1 more source

An N‐Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α‐Conotoxins Targeting Muscle nAChRs

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
α‐RoIA is an atypical N‐terminally elongated conotoxin discovered in Conus rolani. N‐terminal elongation delays activity in vivo; however, this elongation must be removed to block muscle nicotinic acetylcholine receptors (nAChRs). Only the truncated ribbon isoform of RoIA blocks muscle nAChRs.
Matías L. Giglio, Paula Flórez‐Salcedo, Layla Azam, Maren Watkins, Thomas Lund Koch, Erianna Basgall‐De la Rosa, Adam D. Douglass, J. Michael McIntosh, Baldomero M. Olivera, Joanna Gajewiak   +9 more
wiley   +1 more source

The Role of Alpha-7 Nicotinic Acetylcholine Receptors in Pain: Potential Therapeutic Implications. [PDF]

Curr Neuropharmacol
Tao Y, Sun Y, Jiang X, Tao J, Zhang Y.
europepmc   +1 more source

SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors. [PDF]

J Biol Chem, 2023
O'Brien BCV, Weber L, Hueffer K, Weltzin MM.   +3 more
europepmc   +1 more source

Purification and characterization of a protein tyrosine phosphatase which dephosphorylates the nicotinic acetylcholine receptor

, 1991
Lin Mei, Richard L. Huganir
openalex   +1 more source

Concurrent diffusion of nicotinic acetylcholine receptors and fluorescent cholesterol disclosed by two-colour sub-millisecond MINFLUX-based single-molecule tracking. [PDF]

Nat Commun
Reina F, Saavedra LA, Eggeling C, Barrantes FJ.   +3 more
europepmc   +1 more source

Editorial Note: HIV gp120 Induces Mucus Formation in Human Bronchial Epithelial Cells through CXCR4/α7-Nicotinic Acetylcholine Receptors. [PDF]

PLoS One, 2023
PLOS ONE Editors.
europepmc   +1 more source

Orientation of cobra alpha-toxin on the nicotinic acetylcholine receptor. Fluorescence studies.

, 1990
David A. Johnson, R Cushman, R Malekzadeh   +2 more
openalex   +1 more source