Results 251 to 260 of about 42,486 (297)

Nicotinic Acetylcholine Receptors and Epilepsy

Current Drug Target -CNS & Neurological Disorders, 2002
The neuronal nicotinic acetylcholine receptors (nAChRs) have multiple roles in the brain: they are involved in signal transduction by fast synaptic transmission, axo-axonic transmission, and in the modulation of presynaptic transmitter release. Presynaptic nAChRs can increase the release of excitatory as well as of inhibitory transmitters, and can ...
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Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
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Nicotinic Acetylcholine Receptor Assays

Current Protocols in Pharmacology, 1999
AbstractNicotinic acetylcholine receptors (nAChRs) in peripheral tissues are localized almost exclusively to autonomic nerves and the motor end plates of striated musculature. Pharmacologic analyses of nicotinic receptor antagonist potencies can be conducted by assessing the ability of these compounds to inhibit responses elicited by preganglionic ...
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Steroids inhibit nicotinic acetylcholine receptors

NeuroReport, 1991
Application of progesterone to Xenopus oocytes expressing a cloned neuronal nicotinic acetylcholine (nAChR) revealed two effects. The first effect was a fully reversible reduction of the current induced by acetylcholine (ACh), its onset being nearly instantaneous. The second effect, which developed in a few hours, was an irreversible suppression of ACh-
Bertrand, Daniel, Valera, Soledad, Bertrand, Sonia, Ballivet, Marc, Rungger, Duri   +4 more
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Nicotinic Acetylcholine Receptors and Imaging

Current Pharmaceutical Design, 2000
In vivo imaging techniques like positron emission tomography (PET) and single photon emission computed tomography (SPECT) offer the possibility to monitor human central nicotinic acetylcholine receptors (nAChRs) in a variety of central nervous system disorders. In the past, the only available PET radiotracer for imaging nAChRs in the human brain, [11C]-
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Neuronal Nicotinic Acetylcholine Receptors

1996
Studies of the structure and function of neuronal nicotinic acetylcholine receptors (AChRs) evolved out of studies of muscle AChRs. This review will begin with a brief summary of muscle type AChRs because they are the archetype for studies of neuronal nicotinic AChRs in particular and ligand-gated ion channels in general.
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Inhibition of nicotinic acetylcholine receptors by bicuculline

Neuropharmacology, 2001
A study was made on the effects of bicuculline, the classical gamma-aminobutyric acid-A receptor antagonist, on heteromeric mouse muscle alphabetagammadelta, heteromeric neuronal rat alpha2beta4 and alpha4beta2 and homomeric human alpha7 nicotinic acetylcholine receptors (nAChRs), expressed in Xenopus oocytes.
Fabrizio Eusebi, Eleonora Palma, Angelo Demuro, Ricardo Miledi   +3 more
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Toxin insights into nicotinic acetylcholine receptors

Biochemical Pharmacology, 2006
Venomous species have evolved cocktails of bioactive peptides to facilitate prey capture. Given their often exquisite potency and target selectivity, venom peptides provide unique biochemical tools for probing the function of membrane proteins at the molecular level.
Dutertre, S., Lewis, R. J.
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Nicotinic Acetylcholine Receptors and Anesthetics

2003
Nicotinic acetylcholine receptors (nAChRs) are a diverse group of membrane proteins found in many types of excitable tissue, including brain, autonomic ganglia, and muscle. Acetylcholine (ACh), the endogenous ligand for these receptors, binds to agonist sites on nAChRs, causing opening of an intrinsic transmembrane cation channel and depolarization of ...
Stuart A. Forman, Douglas A. Raines, Pamela Flood   +2 more
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The paradox of nicotinic acetylcholine receptor upregulation by nicotine

Trends in Pharmacological Sciences, 1990
Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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