Results 291 to 300 of about 140,109 (356)

Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors. [PDF]

J Med Chem
Hone AJ, Santiago U, Harvey PJ, Tekarli B, Gajewiak J, Craik DJ, Camacho CJ, McIntosh JM.   +7 more
europepmc   +1 more source

Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model

Lassota A, Hodge JJL, Soller M.
europepmc   +1 more source

Subtype-Selective Peptide and Protein Neurotoxic Inhibitors of Nicotinic Acetylcholine Receptors Enhance Proliferation of Patient-Derived Glioblastoma Cell Lines. [PDF]

Toxins (Basel)
Gondarenko E, Mazur D, Masliakova M, Ryabukha Y, Kasheverov I, Utkin Y, Tsetlin V, Shahparonov M, Kudryavtsev D, Antipova N.   +9 more
europepmc   +1 more source

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors. [PDF]

Mar Drugs
Li T, Tae HS, Liang J, Zhang Z, Li X, Jiang T, Adams DJ, Yu R.   +7 more
europepmc   +1 more source

The Cloning and Characterization of a Three-Finger Toxin Homolog (NXH8) from the Coralsnake <i>Micrurus corallinus</i> That Interacts with Skeletal Muscle Nicotinic Acetylcholine Receptors. [PDF]

Toxins (Basel)
Roman-Ramos H, Prieto-da-Silva ÁRB, Dellê H, Floriano RS, Dias L, Hyslop S, Schezaro-Ramos R, Servent D, Mourier G, de Oliveira JL, Lemes DE, Costa-Lotufo LV, Oliveira JS, Menezes MC, Markus RP, Ho PL.   +15 more
europepmc   +1 more source

Analogs of α-conotoxin PnIC selectively inhibit α7β2- over α7-only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism. [PDF]

FASEB J
George AA, John SJ, Lucero LM, Eaton JB, Jaiswal E, Christensen SB, Gajewiak J, Watkins M, Cao Y, Olivera BM, Im W, McIntosh JM, Whiteaker P.   +12 more
europepmc   +1 more source

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Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system.

Annual Review of Pharmacology and Toxicology, 2007
Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with varied functional and pharmacological characteristics. Structural and functional diversity and
J. Dani, D. Bertrand
semanticscholar   +1 more source

The Nicotinic Acetylcholine Receptor

1985
The acetylcholine receptor (AcChR) from Torpedo electroplax has been isolated both in its native membrane-bound state and by affinity chromatography after solubilization (see Conti-Tronconi and Raftery, 1982). Purified membrane fragments can reseal, forming closed, right-side-out vesicles, which can be used for both functional and structural studies ...
Michael A. Raftery, Susan M. J. Dunn, Rebecca D. Crawford, Bianca M. Conti-Tronconi, David S. Middlemas   +4 more
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Nicotinic Acetylcholine Receptors and Epilepsy

Current Drug Target -CNS & Neurological Disorders, 2002
The neuronal nicotinic acetylcholine receptors (nAChRs) have multiple roles in the brain: they are involved in signal transduction by fast synaptic transmission, axo-axonic transmission, and in the modulation of presynaptic transmitter release. Presynaptic nAChRs can increase the release of excitatory as well as of inhibitory transmitters, and can ...
openaire   +3 more sources

Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
openaire   +3 more sources