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Immunology of the Nicotinic Acetylcholine Receptor
1979The classical surface antigens of Enterobacteriaceae: 0, K, and H antigens have been studied extensively in the past and have provided a basis for the taxonomy of this family (Kauffmann, 1966, 1975). In comparison to the vast knowledge accumulated on the structure, localization, genetic determination, and biologic effects of O and K antigens (Weinbaum ...
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The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Trends in Pharmacological Sciences, 1990Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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Protein Phosphorylation of Nicotinic Acetylcholine Receptor
Critical Reviews in Biochemistry and Molecular Biology, 1989The nicotinic acetylcholine receptor (nAcChR) is a ligand-gated ion channel found in the postsynaptic membranes of electric organs, at the neuromuscular junction, and at nicotinic cholinergic synapses of the mammalian central and peripheral nervous system.
Kathryn Miles, Richard L. Huganir
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Ca2+ permeability of nicotinic acetylcholine receptors
Cell Calcium, 2004Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. The nAChR channels are permeable to cations, including Ca(2+). Ca(2+) entry through nAChR channels has been shown to modulate several Ca(2+)-dependent cellular processes, such as neurotransmitter release ...
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Nicotinic Acetylcholine Receptor Modulators
2014Nicotine and its pharmacology have long been associated with schizophrenia and its epidemiology and treatment. Schizophrenics use nicotine in its major delivery form of cigarettes at a significantly higher incidence than the general population (80–90% vs.
Mazurov Anatoly A, Daniel Yohannes
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Nicotinic acetylcholine receptors: An overview
Biochemical Pharmacology, 1984Eric A. Barnard, J. Oliver Dolly
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Nicotinic acetylcholine receptors in the brain
The nicotinic acetylcholine receptor (nAChR) is the archetypal neurotransmitter receptor within the superfamily of pentameric ligand-gated ion channels (pLGICs). Typically, it mediates fast synaptic transmission in response to its endogenous ligand, acetylcholine, and can also intervene in slower signaling mechanisms via intracellular metabolic ...openaire +2 more sources
The wonderland of neuronal nicotinic acetylcholine receptors
Biochemical Pharmacology, 2017D. Bertrand, A. Terry
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Allosteric modulation of nicotinic acetylcholine receptors.
Biochemical Pharmacology, 2015Anna Chatzidaki, N. Millar
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