Results 61 to 70 of about 622,783 (202)

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine.

, 2020
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal muscle paralysis.
Nirthanan, S
core   +1 more source

Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel

Communications Biology, 2022
A structural and functional study of the prokaryotic ligand-gated ion channel, ELIC, provides insight into the origin of agonism and antagonism at nicotinic acetylcholine receptors.
Mykhaylo Slobodyanyuk, Jesús A. Banda-Vázquez, Mackenzie J. Thompson, Rebecca A. Dean, John E. Baenziger, Roberto A. Chica, Corrie J. B. daCosta   +6 more
doaj   +1 more source

Scanning curves and kinetics of the acetylcholine/acetylcholine receptor hysteresis [PDF]

, 1988
Neumann E, Boldt E, Rauer B, Wolf H, Chang HW. Scanning curves and kinetics of the acetylcholine/acetylcholine receptor hysteresis. Bioelectrochemistry and Bioenergetics.
Hendrik Wolf, Boldt, Elvira, Chang, Hai Won, Eberhard Neumann, Rauer, Barbara, Elvira Boldt, Wolf, Hendrik, Hai Won Chang, Barbara Rauer, Neumann, Eberhard   +9 more
core   +1 more source

The Role of Nicotinic Receptors on Ca²⁺ Signaling in Bovine Chromaffin Cells

Current Issues in Molecular Biology
Chromaffin cells have been used as a physiological model to understand neurosecretion in mammals for many years. Nicotinic receptors located in the cells’ membrane are stimulated by acetylcholine, and they participate in the exocytosis of chromaffin ...
Amparo Gil, Virginia González-Vélez, Luis Miguel Gutiérrez, José Villanueva   +3 more
doaj   +1 more source

Structure of nicotinic acetylcholine receptors

Current Opinion in Neurobiology, 1993
Nicotinic acetylcholine (ACh) receptors convert the binding of ACh into the opening of a cation-conducting channel. New information about the regions of the receptor most immediately involved in its function, namely the ACh-binding sites, the gate and the channel, has come from two approaches.
openaire   +2 more sources

Nicotinic acetylcholine receptors modulate osteoclastogenesis [PDF]

Arthritis Research & Therapy, 2016
Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.The presence of nAChR subunits as well as the in-vitro effects of nAChR agonists were investigated by ex vivo osteoclastogenesis assays, real-time polymerase chain reaction, Western blot and flow cytometry in ...
Mandl P, Hayer S, Karonitsch T, Scholze P, Győri, Dávid Sándor, Sykoutri D, Blüml S, Mócsai, Attila, Poór, Gyula, Huck S, Smolen JS, Redlich K   +11 more
openaire   +3 more sources

Acetylcholine and cholinergic receptors

Brain and Neuroscience Advances, 2019
This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic ...
David A. Brown
doaj   +1 more source

Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens [PDF]

, 2004
The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Burzomato, V., Beato, M., Colquhoun, D., Groot-Kormelink, P.J., Sivilotti, L.G.   +4 more
core  

"Warming yang and invigorating qi" acupuncture alters acetylcholine receptor expression in the neuromuscular junction of rats with experimental autoimmune myasthenia gravis

Neural Regeneration Research, 2016
Myasthenia gravis is an autoimmune disorder in which antibodies have been shown to form against the nicotinic acetylcholine nicotinic postsynaptic receptors located at the neuromuscular junction.
Hai-peng Huang, Hong Pan, Hong-feng Wang
doaj   +1 more source

Activation of spinal alpha-7 nicotinic acetylcholine receptor shortens the duration of remifentanil-induced postoperative hyperalgesia by upregulating KCC2 in the spinal dorsal horn in rats

Molecular Pain, 2017
Background Accumulating evidence has shown that the signal from spinal brain-derived neurotrophic factor/tyrosine receptor kinase B-K + -Cl − cotransporter-2 plays a critical role in the process of pain hypersensitivity.
Wei Gu, Wei Zhang, Yishan Lei, Yin Cui, Shuaishuai Chu, Xiaoping Gu, Zhengliang Ma   +6 more
doaj   +1 more source