Results 61 to 70 of about 35,240 (226)

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Activation of spinal alpha-7 nicotinic acetylcholine receptor shortens the duration of remifentanil-induced postoperative hyperalgesia by upregulating KCC2 in the spinal dorsal horn in rats

Molecular Pain, 2017
Background Accumulating evidence has shown that the signal from spinal brain-derived neurotrophic factor/tyrosine receptor kinase B-K + -Cl − cotransporter-2 plays a critical role in the process of pain hypersensitivity.
Wei Gu, Wei Zhang, Yishan Lei, Yin Cui, Shuaishuai Chu, Xiaoping Gu, Zhengliang Ma   +6 more
doaj   +1 more source

Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors

Frontiers in Cellular Neuroscience, 2015
Prefrontal layer 6 (L6) pyramidal neurons play an important role in the adult control of attention, facilitated by their strong activation by nicotinic acetylcholine receptors.
Lily eKang, Michael K Tian, Craig D. C. Bailey, Craig D. C. Bailey, Evelyn K Lambe, Evelyn K Lambe, Evelyn K Lambe   +6 more
doaj   +1 more source

Chrysin Mitigates Acetamiprid‐Induced Testicular Injury in Mice via Suppression of Endoplasmic Reticulum Stress and Inflammation

Environmental Toxicology, EarlyView.
ABSTRACT Acetamiprid (ACP) is a neonicotinoid pesticide that is extensively utilized for the management of insect populations, but its toxic effects on the male reproductive system have become a source of concern. Chrysin (CHR) is a natural flavone found in many plants and bee products, including honey and propolis.
Selim Demir, Nihal Turkmen Alemdar, Esin Yulug, Ali Kulaber, Elif Ayazoglu Demir, Nadire Sevdenur Erdogan, Ahmet Mentese, Yuksel Aliyazicioglu   +7 more
wiley   +1 more source

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission

Cell Reports, 2018
Summary: Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown.
Yijin Yan, Can Peng, Matthew C. Arvin, Xiao-Tao Jin, Veronica J. Kim, Matthew D. Ramsey, Yong Wang, Sambashiva Banala, David L. Wokosin, J. Michael McIntosh, Luke D. Lavis, Ryan M. Drenan   +11 more
doaj   +1 more source

Penile intracavernosal injection of succinylcholine for laryngospasm management during hypospadias repair

UroPrecision, EarlyView.
Abstract Background Laryngospasm is a serious anesthetic complication that can lead to acute airway obstruction and hypoxemia. Standard management involves deepening anesthesia and administering succinylcholine intravenously (IV) or intramuscularly (IM). However, if IV access is lost or IM drug delivery is too slow, alternative routes are required.
Diego R. Álvarez Vega, Mariela R. Martinez, Steven Friedman, Tehilla Adams, Jordan L. Mendelson, William Nguyen, Jordan S. Gitlin   +6 more
wiley   +1 more source

Clinical reasoning in feline non‐ambulatory tetraparesis or tetraplegia: Which combination of clinical information is useful?

Veterinary Record, EarlyView.
Abstract Background Non‐ambulatory tetraparesis or tetraplegia in cats may constitute a diagnostic challenge for general practitioners. Therefore, this study aimed to evaluate if clinical variables from signalment, history, clinical examination and basic ancillary tests are associated with underlying diagnoses in cats with non‐ambulatory tetraparesis ...
Guido Bertoldi, Steven De Decker
wiley   +1 more source

Variations in “Functional Site” Residues and Classification of Three-Finger Neurotoxins in Snake Venoms

Toxins
Three-finger toxins (3FTxs) are the largest group of nonenzymatic toxins found in snake venoms. Among them, neurotoxins that target nicotinic acetylcholine receptors are the most well-studied ligands.
R. Manjunatha Kini, Cho Yeow Koh
doaj   +1 more source

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview

Marine Drugs, 2014
Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom.
Eline K. M. Lebbe, Steve Peigneur, Isuru Wijesekara, Jan Tytgat   +3 more
doaj   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source