Results 71 to 80 of about 622,783 (202)

Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors

Frontiers in Cellular Neuroscience, 2015
Prefrontal layer 6 (L6) pyramidal neurons play an important role in the adult control of attention, facilitated by their strong activation by nicotinic acetylcholine receptors.
Lily eKang, Michael K Tian, Craig D. C. Bailey, Craig D. C. Bailey, Evelyn K Lambe, Evelyn K Lambe, Evelyn K Lambe   +6 more
doaj   +1 more source

Molecular characterisation of insect nicotinic acetylcholine receptors [PDF]

, 2003
Nicotinic acetylcholine receptors (nAChRs) are pentameric multi-subunit proteins that form ligand-gated ion channels in the central nervous systems of vertebrates and invertebrates and at the neuromuscular junction of vertebrate species. In insects, they
Kirwan, M. J., Kirwan, Michael Joseph
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Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission

Cell Reports, 2018
Summary: Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown.
Yijin Yan, Can Peng, Matthew C. Arvin, Xiao-Tao Jin, Veronica J. Kim, Matthew D. Ramsey, Yong Wang, Sambashiva Banala, David L. Wokosin, J. Michael McIntosh, Luke D. Lavis, Ryan M. Drenan   +11 more
doaj   +1 more source

Variations in “Functional Site” Residues and Classification of Three-Finger Neurotoxins in Snake Venoms

Toxins
Three-finger toxins (3FTxs) are the largest group of nonenzymatic toxins found in snake venoms. Among them, neurotoxins that target nicotinic acetylcholine receptors are the most well-studied ligands.
R. Manjunatha Kini, Cho Yeow Koh
doaj   +1 more source

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview

Marine Drugs, 2014
Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom.
Eline K. M. Lebbe, Steve Peigneur, Isuru Wijesekara, Jan Tytgat   +3 more
doaj   +1 more source

Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site. [PDF]

, 1995
Agrin is a basal lamina protein that induces aggregation of acetylcholine receptors (AChRs) and other molecules at the developing neuromuscular junction.
Ruegg, M. A., A J Denzer, Denzer, A J, M A Ruegg, Gesemann, M., M Gesemann, Gesemann, M, Ruegg, M A, Denzer, A. J.   +8 more
core   +1 more source

Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons

Journal of Pharmacological Sciences, 2010
We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor
Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izumi, Tetsuhiro Niidome, Takeshi Fujii, Hachiro Sugimoto, Akinori Akaike   +6 more
doaj   +1 more source

Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]

, 2007
Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D., Groot-Kormelink, P., Plested, A.J.R., Sivilotti, L.G.   +3 more
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Functions and pharmacology of α2β2 nicotinic acetylcholine receptors; in and out of the shadow of α4β2 nicotinic acetylcholine receptors. [PDF]

Biochem Pharmacol
Although α2 was the first neuronal nicotinic acetylcholine receptor (nAChR) receptor subunit to be cloned, due to its low level of expression in rodent brain, its study has largely been neglected. This study provides a comparison of the α2 and α4 structures and their functional similarities, especially in regard to the existence of low and high ...
Papke RL.
europepmc   +3 more sources

Synthese, Assemblierung und intrazellulärer Transport von Mitgliedern der cys-loop- und P2X-Familie liganden-gesteuerter Ionenkanäle [PDF]

, 2006
The results presented here strongly indicate that ubiquitination of the recombinant human alpha1 GlyR at the plasma membrane of Xenopus oocytes is involved in receptor internalisation and degradation.
Sadtler, Sven
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