Results 51 to 60 of about 622,783 (202)

Heterogenous Cholinergic Nicotinic Receptors in the CNS

, 1988
Multiple nicotinic binding sites are found in mammalian brain. Several nicotinic agonists and antagonists have been used to characterize the nicotinic binding sites.
Nilsson, L, Abdu Adem, Luciana Romanelli, Nordberg, A, Lena Nilsson, Adem, A, Xiao Zhang, Zhang, X, Agneta Nordberg, Romanelli, L   +9 more
core   +1 more source

Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen [PDF]

, 2002
The weakness in myasthenia gravis (MG) is mediated by autoantibodies against adult muscle acetylcholine receptors (AChR) at the neuromuscular junction; most of these antibodies also bind to fetal AChR, which is present in the thymus.
Wilcox, Nick, Matthews, I, Stott, David, Ledwidge, S, Vincent, Angela, Willcox, N, Beeson, David, Vincent, A, Sims, G, Stott, D, Matthews, Ian, Sims, Gary, Ledwidge, Serena, Beeson, D   +13 more
core   +1 more source

Unique nicotinic responses are present in distinct subtypes of mouse medial prefrontal layer V pyramidal neurons

Scientific Reports
The neurotransmitter acetylcholine supports goal-directed cognitive functions via activation of its nicotinic and muscarinic classes of receptors within the prefrontal cortex.
Ashutosh V. Patel, Anthony Nguyen, Ashley A. Geremia, Donia Zeng, Pietro Paletta, Elena Choleris, Craig D. C. Bailey   +6 more
doaj   +1 more source

Philanthotoxin analogues that selectively inhibit ganglionic nicotinic acetylcholine receptors with exceptional potency [PDF]

, 2019
Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 non-selectively inhibits several excitatory ligand-gated ion channels, and we recently showed that its synthetic analogue ...
Kachel, Hamid S., Mellor, Ian R., Franzyk, Henrik   +2 more
core   +1 more source

Impulsive Behavior and Nicotinic Acetylcholine Receptors

Journal of Pharmacological Sciences, 2012
Higher impulsivity is thought to be a risk factor for drug addiction, criminal involvement, and suicide. Excessive levels of impulsivity are often observed in several psychiatric disorders including attention-deficit/hyperactivity disorder and ...
Yu Ohmura, Iku Tsutsui-Kimura, Mitsuhiro Yoshioka   +2 more
doaj   +1 more source

Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus [PDF]

, 2012
Nicotine is known to enhance long-term hippocampus dependent learning and memory in both rodents and humans via its activity at nicotinic acetylcholinergic receptors (nAChRs).
Rachel L Poole, Gould, Thomas J., Michael D Adoff, Gould Thomas J., Kenney, Justin W., Thomas J Gould, Poole Rachel L., Poole, Rachel L., Logue, Sheree F., Kenney Justin W., Justin W Kenney, Sheree F Logue, Logue Sheree F., Adoff, Michael D., Adoff Michael D.   +14 more
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Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine [PDF]

BMC Structural Biology, 2002
Nicotine is a psychoactive drug presenting a diverse array of biological activities, some positive, such as enhancement of cognitive performances, others negative, such as addiction liability. Ligands that discriminate between the different isotypes of nicotinic acetylcholine receptors (nAChRs) could present improved pharmacology and toxicity profile ...
Schapira, Matthieu, Abagyan, Ruben, Totrov, Maxim   +2 more
openaire   +4 more sources

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]

, 1992
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Tsim, K. W., McMahan, U. J., Escher, G., Gensch, Erin M., Tsim, Karl W.K., Escher, Gérard, Kroger, S., Kröger, Stephan, Horton, Sharon E., Ruegg, M. A., Tsim, Karl W. K., Horton, S. E., Gensch, E. M., Ruegg, Markus A.   +13 more
core   +1 more source

Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia

Neurobiology of Disease, 2019
Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects.
Anthony M. Downs, Xueliang Fan, Christine Donsante, H.A. Jinnah, Ellen J. Hess   +4 more
doaj   +1 more source

Nicotinic acetylcholine receptors of nerve and muscle: Functional aspects

, 1987
Cloning studies suggest that there are at least five types of nicotinic receptor with different amino acid sequences. David Colquhoun and colleagues discuss pharmacological consequences of this heterogeneity.
David Colquhoun, Alistair Mathie, David C. Ogden   +2 more
core   +1 more source