Results 51 to 60 of about 35,240 (226)

Nicotinic acetylcholine receptors as targets for antidepressants [PDF]

Molecular Psychiatry, 2002
While the monoamine deficiency hypothesis of depression is still most commonly used to explain the actions of antidepressant drugs, a growing body of evidence has accumulated that is not adequately explained by the hypothesis. This article draws attention to contributions from another apparently common pharmacological property of antidepressant ...
R D, Shytle, A A, Silver, R J, Lukas, M B, Newman, D V, Sheehan, P R, Sanberg   +5 more
openaire   +2 more sources

Functions and pharmacology of α2β2 nicotinic acetylcholine receptors; in and out of the shadow of α4β2 nicotinic acetylcholine receptors. [PDF]

Biochem Pharmacol
Although α2 was the first neuronal nicotinic acetylcholine receptor (nAChR) receptor subunit to be cloned, due to its low level of expression in rodent brain, its study has largely been neglected. This study provides a comparison of the α2 and α4 structures and their functional similarities, especially in regard to the existence of low and high ...
Papke RL.
europepmc   +3 more sources

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel

Communications Biology, 2022
A structural and functional study of the prokaryotic ligand-gated ion channel, ELIC, provides insight into the origin of agonism and antagonism at nicotinic acetylcholine receptors.
Mykhaylo Slobodyanyuk, Jesús A. Banda-Vázquez, Mackenzie J. Thompson, Rebecca A. Dean, John E. Baenziger, Roberto A. Chica, Corrie J. B. daCosta   +6 more
doaj   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

The Role of Nicotinic Receptors on Ca²⁺ Signaling in Bovine Chromaffin Cells

Current Issues in Molecular Biology
Chromaffin cells have been used as a physiological model to understand neurosecretion in mammals for many years. Nicotinic receptors located in the cells’ membrane are stimulated by acetylcholine, and they participate in the exocytosis of chromaffin ...
Amparo Gil, Virginia González-Vélez, Luis Miguel Gutiérrez, José Villanueva   +3 more
doaj   +1 more source

Effects of bioinsecticide exposure route on aphids and their natural enemies in oilseed rape

Pest Management Science, EarlyView.
Fatty acids, silicone polymers and surfactants reduced aphid numbers but caused natural enemy mortality under direct exposure, while minimal residual activity suggests potential for targeted, compatible use in integrated pest management. Abstract BACKGROUND Myzus persicae Sulzer and Brevicoryne brassicae L.
Aimee J. Tonks, Tom W. Pope, Simon Cooper, Joe M. Roberts   +3 more
wiley   +1 more source

Acetylcholine and cholinergic receptors

Brain and Neuroscience Advances, 2019
This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic ...
David A. Brown
doaj   +1 more source

Assessing the potential for insecticide cross‐resistance to a novel insecticide in the Colorado potato beetle (Leptinotarsa decemlineata) using phenotypic and transcript expression analysis

Pest Management Science, EarlyView.
Phenotypic and transcriptional responses to imidacloprid and isocycloseram were examined across U.S. populations of the Colorado potato beetle, showing evidence of phenotypic cross‐resistance alongside population‐level variation in detoxification gene expression.
Emma E. Terris, Benjamin Z. Bradford, Faith Kulzer, Justin Clements, Kurt H. Lamour, Sean D. Schoville, Russell L. Groves   +6 more
wiley   +1 more source

"Warming yang and invigorating qi" acupuncture alters acetylcholine receptor expression in the neuromuscular junction of rats with experimental autoimmune myasthenia gravis

Neural Regeneration Research, 2016
Myasthenia gravis is an autoimmune disorder in which antibodies have been shown to form against the nicotinic acetylcholine nicotinic postsynaptic receptors located at the neuromuscular junction.
Hai-peng Huang, Hong Pan, Hong-feng Wang
doaj   +1 more source