Results 241 to 250 of about 5,428,052 (282)

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, Volume 13, Issue 9, 13 February 2026.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Insights into host dependency from a chemically defined medium for the human vaginal bacterium Lactobacillus crispatus. [PDF]

Arch Microbiol
Achterberg P, van Geenen NJK, Hertzberger RY, Molenaar D, van Loosdrecht MCM, Kort R.   +5 more
europepmc   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Integrative Neuroimmune Role of the Parasympathetic Nervous System, Vagus Nerve and Gut Microbiota in Stress Modulation: A Narrative Review. [PDF]

Int J Mol Sci
Kurhaluk N, Kołodziejska R, Kamiński P, Tkaczenko H.   +3 more
europepmc   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, Volume 13, Issue 8, 9 February 2026.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

Hepatic FGF21 Deletion Improves Glucose Metabolism, Alters Lipogenic and <i>Chrna4</i> Gene Expression, and Enhances Telomere Maintenance in Aged Female Mice. [PDF]

Int J Mol Sci
Torres-Oteros D, Nicola-Llorente M, Sanz-Lamora H, Pérez-Martí A, Marrero PF, Canudas S, Haro D, Relat J.   +7 more
europepmc   +1 more source

Multi‐Omics Insights Into the Role of Fructooligosaccharides Supplementation in Alleviating Salpingitis in Laying Hens

Animal Research and One Health, Volume 4, Issue 1, Page 105-119, February 2026.
Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song, Tao Duan, Rong Li, Xiaoqiu Wang, Fengdong Zhang, Jia Feng, Lin Qiao, Junlin Cheng, Lixian Chen, Aike Li, Yuna Min, Weiwei Wang   +11 more
wiley   +1 more source

Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in Drosophila. [PDF]

Neurochem Res
Kruth K, Kasuya J, Hand V, Iyengar A, Kitamoto T.   +4 more
europepmc   +1 more source

The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology. [PDF]

Int J Mol Sci
Lee YC, Lin SJ.
europepmc   +1 more source

What Is a Vitamin? Towards a Contemporary Definition. [PDF]

Nutrients
Hahn A, Eggersdorfer M, Kerlikowsky F.
europepmc   +1 more source