Results 241 to 250 of about 5,143,045 (401)

Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease

Cell Proliferation, EarlyView.
We speculated lack of Klotho (KL) would aggravate club cell senescence, which contributes to COPD inflammation. In this study, we collected chronic obstructive pulmonary disease (COPD) lung tissue using single‐cell RNA sequencing (scRNA‐seq), revealing club cell heterogeneity and cellular senescence in COPD.
Min Li, Bo Chen, Sibo Sun, Kai Wang, Yu Wang, Jianqing Wu   +5 more
wiley   +1 more source

Effects on Performance, Immunological Response and Short-Chain Fatty Acid Profile in Feces of Nursery Piglets Fed with Organic Acids and Yeast Wall. [PDF]

Animals (Basel)
Ficagna CA, Silva ASD, Rofino RD, Zatti E, Esposito T, Xavier ACH, Wagner R, Bissacotti BF, Seghetto RB, Ternus EM, Paiano D.   +10 more
europepmc   +1 more source

THE BIOLOGICAL ACTIVITY OF A PRECURSOR OF NICOTINIC ACID IN CEREAL PRODUCTS

, 1944
Willard A. Krehl, C. A. Elvehjem, F. M. Strong   +2 more
openalex   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Targeting Mitochondrial Dysfunction to Prevent Endothelial Dysfunction and Atherosclerosis in Diabetes: Focus on the Novel Uncoupler BAM15. [PDF]

Int J Mol Sci
Jang WB, Rethineswaran VK, Kwon SM.
europepmc   +1 more source

Treatment of Asthma by Nicotinic Acid [PDF]

BMJ, 1943
openaire   +3 more sources

Primary structure of a developmentally regulated nicotinic acetylcholine receptor protein from Drosophila

EMBO Journal, 1986
I. Hermans‐Borgmeyer, D. Zopf, R. Ryseck, B. Hovemann, H. Betz, E. Gundelfinger   +5 more
semanticscholar   +1 more source

Transcriptional response in larvae of the generalist fruit fly Anastrepha obliqua feeding on three different tropical host plants

Entomologia Experimentalis et Applicata, EarlyView.
We investigated the molecular basis of host switching by the phytophagous West Indian fruit fly (A. obliqua). Third‐instar larvae showed differential gene expression according to host plants: red mombin, mango, and carambola. The main gene categories differentially expressed were digestion, detoxification, and gene regulators.
Sandra M. Velasco‐Cuervo, César A. Lemos‐Lucumi, Maria R. Manzano, Stephen E. Strelkov, Nelson Toro‐Perea, Leonardo Galindo‐González   +5 more
wiley   +1 more source

Human plasma protein bindings of neonicotinoid insecticides and metabolites. [PDF]

Sci Rep
Taira K, Ikenaka Y, Bonmatin JM, Safer A.   +3 more
europepmc   +1 more source

Macrophages and autophagy: partners in crime

The FEBS Journal, EarlyView.
Autophagy is a key regulator of macrophage function, influencing critical processes like polarization, cytokine secretion, and phagocytosis. Its impact on macrophage behavior varies across different tissues and disease contexts, where it can either promote protective responses or contribute to detrimental outcomes, depending on the physiological or ...
Alessandra Vitaliti, Alessio Reggio, Alessandro Palma   +2 more
wiley   +1 more source