Results 301 to 310 of about 65,529 (332)
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Nicotinic Acid Requirements of Insects: a Biological Test for Nicotinic Acid
Nature, 1939THE importance of vitamin B for the growth and development of insects has been stressed by several investigators. But very little is known of the ingredients of the vitamin B complex which are actually required by the insects.
D. Rubinstein, L. Shekun
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1971
Publisher Summary This chapter focuses on the enzymatic preparation of nicotinic acid adenine dinucleotide (Deamido-NAD), nicotinic acid ribonucleotide, and nicotinic acid ribonucleoside. The principle, assay method, materials used, and procedure are described.
Yasutomi Nishizuka, Tasuku Honjo
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Publisher Summary This chapter focuses on the enzymatic preparation of nicotinic acid adenine dinucleotide (Deamido-NAD), nicotinic acid ribonucleotide, and nicotinic acid ribonucleoside. The principle, assay method, materials used, and procedure are described.
Yasutomi Nishizuka, Tasuku Honjo
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Nicotinic acid: recent developments
Current Opinion in Cardiology, 2008To review the recent progress in niacin research that is made in two major areas: new preparations to decrease flushing and niacin's mechanism of action.Flushing, an adverse effect of niacin, results from GPR109A-mediated production of prostaglandin D2 and E2 in Langerhans' cells which act on DP1 and EP2/4 receptors in dermal capillaries causing their ...
Vaijinath S. Kamanna +2 more
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Journal of the American Medical Association, 1938
During the early period of investigation of vitamins Funk demonstrated that nicotinic acid is a constituent of the vitamin B complex. At a later date Elvehjem and his collaborators1in their search for the antipellagra factor isolated nicotinic acid from highly active concentrates and found that a commercial preparation of this compound was highly ...
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During the early period of investigation of vitamins Funk demonstrated that nicotinic acid is a constituent of the vitamin B complex. At a later date Elvehjem and his collaborators1in their search for the antipellagra factor isolated nicotinic acid from highly active concentrates and found that a commercial preparation of this compound was highly ...
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Tolerance to nicotinic acid flushing
Clinical Pharmacology and Therapeutics, 1991The mechanism of tolerance to nicotinic acid flushing was determined in subjects during a 5-day course of treatment. Objective measures of skin blood flow were used to confirm the development of tolerance. Plasma levels of nicotinic acid showed marked intraindividual variability but were not decreased with the development of tolerance.
Ralph H. Stern +3 more
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Nicotinic Acid for the Treatment of Hyperlipoproteinemia
The Journal of Clinical Pharmacology, 1991Nicotinic acid is a water‐soluble B‐complex vitamin that has been shown, in high doses, to lower total plasma cholesterol (C), LDL‐C, and VLDL‐triglycerides (Tg), while raising HDL‐C in patients with type II, III, IV, and V hyperlipoproteinemia. Its exact mechanism of action is not known, but it appears to lower the production of VLDL in the liver ...
William H. Frishman +2 more
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Nicotinic Acid and Hypercholesterolemia
Archives of Internal Medicine, 1990To the Editor.—In their excellent discussion of the role of high-density lipoprotein in the management of hypercholesterolemia, Grundy et al1take note of the fact that nicotinic acid is a first-line drug for the treatment of an elevated low-density lipoprotein—cholesterol (if diet alone has been insufficient) and, in addition, that it has the capacity ...
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EXCRETION OF NICOTINIC ACID IN TYPHOID
Archives of Internal Medicine, 1947THE LITERATURE contains many reports on the association of typhoid and pellagra. Bean and others, 1 in a review on secondary pellagra, assumed that in typhoid the rise in metabolism due to the prolonged fever leads to increased demands on the system of catalysts and brings about a state of deficiency.
K. Braun, N. Grossowicz
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Nicotinic acid inhibition of uricase
Irish Journal of Medical Science, 1969Nicotinic acid, a drug which produces hyperuricaemia has been shown to be an inhibitor of uricase, the bacterial enzyme responsible for the elimination of a considerable portion of the body’s uric acid. Calculations indicate that inhibitory levels of the drug could arise in the intestine during therapy causing the hyperuricaemia observed during ...
Oliver FitzGerald +2 more
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Antiatherothrombotic effects of nicotinic acid
Atherosclerosis, 2003Cardiovascular event reduction in hypercholesterolemic subjects appropriately emphasizes the prominent role of statin therapy; however, niacin (nicotinic acid) is also an effective lipid-altering agent that prevents atherosclerosis and reduces cardiovascular events.
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