Results 91 to 100 of about 2,143 (224)

Estimating the impact of treatment compliance over time on smoking cessation using data from ecological momentary assessments (EMA) [PDF]

arXiv, 2020
The Wisconsin Smoker's Health Study (WSHS2) was a longitudinal trial conducted to compare the effectiveness of two commonly used smoking cessation treatments, varenicline and combination nicotine replacement therapy (cNRT) with the less intense standard of care, nicotine patch.
arxiv  

Blood phosphatidylethanol measurements indicate GLP‐1 receptor stimulation causes delayed decreases in alcohol consumption

Alcohol, Clinical and Experimental Research, EarlyView.
Glucagon‐like peptide 1 receptor agonists (GLP‐1RAs) are effective for treating obesity (BMI ≥30) and are being investigated as a novel treatment for alcohol use disorder (AUD). This secondary analysis of a randomized clinical trial evaluated the effect of exenatide versus placebo on alcohol consumption using phosphatidylethanol (PEth) in 30 AUD ...
Mathias E. Jensen, Mette K. Klausen, Marianne L. Bergmann, Gitte M. Knudsen, Tina Vilsbøll, Christophe Stove, Anders Fink‐Jensen   +6 more
wiley   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

Case series: Symptom‐inhibited fentanyl induction (SIFI) onto treatment‐dose opioid agonist therapy in a community setting

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Existing opioid agonist therapy (OAT) guidelines are far from sufficient to address rising opioid tolerances and potency of the unregulated opioid market in North America. Inadequate starting doses of OAT are a universally recognized barrier for people who use fentanyl.
Pouya Azar, Jane J. Kim, Ruth Davison, Zoran Barazanci, Martha J. Ignaszewski, James S. H. Wong, Jessica Machado, Marianne Harris, Michael Krausz, Nickie Mathew, Andrew Herring, Julio S. G. Montaner   +11 more
wiley   +1 more source

The role of alpha-7 nicotinic receptors in food intake behaviors

Frontiers in Psychology, 2014
Nicotine alters appetite and energy expenditure, leading to changes in body weight. While the exact mechanisms underlying these effects are not fully established, both central and peripheral involvement of the alpha-7 nicotinic acetylcholine receptor ...
Kristina L. McFadden, Marc-Andre eCornier, Jason R. Tregellas, Jason R. Tregellas   +3 more
doaj   +1 more source

Effect of E-cigarette Use and Social Network on Smoking Behavior Change: An agent-based model of E-cigarette and Cigarette Interaction [PDF]

arXiv, 2019
Despite a general reduction in smoking in many areas of the developed world, it remains one of the biggest public health threats. As an alternative to tobacco, the use of electronic cigarettes (ECig) has been increased dramatically over the last decade. ECig use is hypothesized to impact smoking behavior through several pathways, not only as a means of
arxiv  

Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases

Neural Regeneration Research, 2017
Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked.
Laura Foucault-Fruchard, Daniel Antier
doaj   +1 more source

A physical model of nicotinic ACh receptor kinetics [PDF]

arXiv, 2008
We present a new approach to nicotinic receptor kinetics and a new model explaining random variabilities in the duration of open events. The model gives new interpretation on brief and long receptor openings and predicts (for two identical binding sites) the presence of three components in the open time distribution: two brief and a long.
arxiv  

Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

Biophysical Journal, 1991
The nicotinic acetylcholine receptor (AChR) is a pentameric transmembrane protein (alpha 2 beta gamma delta) that binds the neurotransmitter acetylcholine (ACh) and transduces this binding into the opening of a cation selective channel. The agonist, competitive antagonist, and snake toxin binding functions of the AChR are associated with the alpha ...
Gordon F. Tomaselli, Edward Hawrot, M.E. Jurman, J.T. McLaughlin, Gary Yellen   +4 more
openaire   +3 more sources

Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice

Nature Communications
Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen, Peter M. Klein, Cheng Xie, Katelyn N. Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T. Bendor, Barna Dudok, Jordan S. Farrell, Tilo Gschwind, Charlotte L. Porter, Annahita Keravala, G. Steven Dodson, Ivan Soltesz   +13 more
doaj   +1 more source