Results 91 to 100 of about 484,958 (335)
Japanese Journal of Pharmacology, 1998 Effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], a selective nicotinic agonist, on locomotor activity and dopamine turnover were examined and compared to those of nicotine to test if GTS-21 exhibits side effects similar to ...
M. Nanri +4 more
semanticscholar +1 more source
Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
Epilepsia Open, EarlyView.Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang +3 more
wiley +1 more source
Journal of Neuroinflammation, 2005 Background Nicotinic acetylcholine (Ach) receptors are ligand-gated pentameric ion channels whose main function is to transmit signals for the neurotransmitter Ach in peripheral and central nervous system.
Minghetti Luisa +3 more
doaj +1 more source
Achieving maximal speed of solution exchange for patch clamp experiments. [PDF]
PLoS ONE, 2012 BACKGROUND: Resolving the kinetics of agonist binding events separately from the subsequent channel gating processes requires the ability of applying and removing the agonist before channel gating occurs.
Jerónimo Auzmendi +3 more
doaj +1 more source
Japanese Journal of Pharmacology, 1998 We examined the effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], a nicotinic agonist, on histopathological changes of the brain and radial maze learning performance in rats with permanent occlusion of the bilateral common ...
M. Nanri +4 more
semanticscholar +1 more source
Making America Healthy Again: Remedies for Robert F. Kennedy Jr.'s Campaign against Chronic Disease
Hastings Center Report, EarlyView.Abstract Chronic diseases impose enormous health and economic burdens in the United States, especially on marginalized populations, and demand evidence‐based, equity‐focused interventions. To combat chronic disease, the Trump administration established the Make America Healthy Again Commission, chaired by Department of Health and Human Services ...
Lawrence O. Gostin +2 more
wiley +1 more source
Nature Communications, 2023 The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7
Marie S. Prevost +11 more
doaj +1 more source
Neurotensin Agonist Attenuates Nicotine Potentiation to Cocaine Sensitization [PDF]
Behavioral Sciences, 2014 Tobacco usage typically precedes illicit drug use in adolescent and young adult populations. Several animal studies suggest nicotine increases the risk for subsequent cocaine abuse, and may be a negative prognostic factor for treatment of cocaine addiction; i.e., a “gateway drug”. Neurotensin (NT) is a 13-amino acid neuropeptide that modulates dopamine,
Bethany Stennett +3 more
openaire +4 more sources
Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens [PDF]
, 2004 The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Beato, M. +4 more
core
New strategic insights into managing fungal biofilms [PDF]
, 2015 Fungal infections have dramatically increased in the last decades in parallel with an increase of populations with impaired immunity, resulting from medical conditions such as cancer, transplantation or other chronic diseases.
Borghi, Elisa +6 more
core +3 more sources