Results 121 to 130 of about 493,465 (339)

The SARS-CoV-2 Virus and the Cholinergic System: Spike Protein Interaction with Human Nicotinic Acetylcholine Receptors and the Nicotinic Agonist Varenicline. [PDF]

Int J Mol Sci, 2023
Carlson EC, Macsai M, Bertrand S, Bertrand D, Nau J.   +4 more
europepmc   +1 more source

A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue [PDF]

, 2008
Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-{pi} interaction with the agonist, whereas in GABAA receptors, a Tyr performs this role.
Dougherty, Dennis A., Hanek, Ariele P., Lester, Henry A., Lummis, Sarah C. R., Lynch, Joseph W., Millen, Kat S., Pless, Stephan A.   +6 more
core   +2 more sources

Psilocybin‐assisted psychotherapy for methamphetamine use disorder: A pilot open‐label safety and feasibility study

Addiction, EarlyView.
Abstract Background & Aims There are few effective treatments for methamphetamine use disorder, despite increasing global demand. Here, we assessed the safety and feasibility of outpatient psilocybin‐assisted psychotherapy for methamphetamine use disorder. Design Single arm, open label pilot study.
Elizabeth Knock, Krista J. Siefried, Gill Bedi, Steven Albert, Richard O. Day, Nadine Ezard, Margaret Ross, Paul Liknaitzky, Jonathan Brett   +8 more
wiley   +1 more source

A tight coupling between β\u3csub\u3e2\u3c/sub\u3eY97 and β\u3csub\u3e2\u3c/sub\u3eF200 of the GABA\u3csub\u3eA\u3c/sub\u3e receptor mediates GABA binding [PDF]

, 2011
The GABAA receptor is an oligopentameric chloride channel that is activated via conformation changes induced upon the binding of the endogenous ligand, GABA, to the extracellular inter-subunit interfaces. Although dozens of amino acid residues at the α/β
Laha, Kurt T., Tran, Phu N., Wagner, David A.   +2 more
core   +1 more source

Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Aims To assess whether combining nicotine replacement therapy (NRT) with varenicline improves long‐term smoking cessation rates compared with varenicline or NRT alone. Method Systematic review and meta‐analysis of randomized controlled trials (RCTs) or quasi‐RCTs, conducted according to PRISMA guidelines.
Xinmei Zhou, Zhenxiao Huang, Qingqing Song, Xin Xia, Anqi Cheng, Zhao Liu, Min Wang, Tingfen Ji, Ailifeire Aihemaiti, Ying Xie, Yi Liu, Yuxin Shi, Shunyi Shi, Yingman Gao, Hang Liu, Jiahui He, Liang Zhao, Dan Xiao, Chen Wang   +18 more
wiley   +1 more source

Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases

Neural Regeneration Research, 2017
Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked.
Laura Foucault-Fruchard, Daniel Antier
doaj   +1 more source

Contingency management interventions for substance use and addictive behaviours: Review of the United Kingdom evidence base

Addiction, EarlyView.
Abstract Background and aims Substance use and other addictive behaviours including gambling remain major public health concerns in the UK. Despite the effectiveness of substance use treatment approaches, treatment adherence and success rates remain low.
Carol‐Ann Getty, Tricia McQuarrie, Eileen Brobbin   +2 more
wiley   +1 more source

Neurodevelopmental burden in young adults undergoing opioid substitution therapy: The role of inattentive and hyperactive/impulsive symptoms

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Attention‐deficit/hyperactivity disorder (ADHD) is recognized as a condition that can persist into adulthood, often with psychiatric comorbidities that worsen the overall prognosis. ADHD has been associated with substance use disorders (SUDs), especially through symptoms like hyperactivity and impulsivity, while the ...
Maddalena Cesco, Marco Garzitto, Livia Pischiutta, Tiziana Lombardelli, Enrico Moratti, Giuliano Zamparutti, Matteo Balestrieri, Umberto Albert, Marco Colizzi   +8 more
wiley   +1 more source

Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice

Nature Communications
Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen, Peter M. Klein, Cheng Xie, Katelyn N. Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T. Bendor, Barna Dudok, Jordan S. Farrell, Tilo Gschwind, Charlotte L. Porter, Annahita Keravala, G. Steven Dodson, Ivan Soltesz   +13 more
doaj   +1 more source

Physostigmine and Galanthamine Bind in the Presence of Agonist at the Canonical and Noncanonical Subunit Interfaces of a Nicotinic Acetylcholine Receptor [PDF]

, 2013
Ayman K. Hamouda, Tilia Kimm, Jonathan B. Cohen   +2 more
openalex   +1 more source