Results 161 to 170 of about 40,056 (270)
Archiv der Pharmazie, Volume 359, Issue 4, April 2026.Biomimetic supramolecular hosts in water affect outcomes and behavior of E/Z‐isomerizations. A deeper understanding of such effects can pave the way to understanding photochemical processes in more complex biological environments. The review displays examples of supramolecular hosts affecting the outcomes of E/Z‐isomerizations and subsequently ...
Doğan Akbulut +2 more
wiley +1 more source
Arthritis &Rheumatology, Volume 78, Issue 4, Page 985-992, April 2026.Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty +4 more
wiley +1 more source
Cancer Nexus, Volume 2, Issue 2, April 2026.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source
Effects of Cedirogant on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates
Clinical Pharmacology in Drug Development, Volume 15, Issue 4, April 2026.Abstract This study aimed to characterize the effects of cedirogant, an inverse agonist of retinoic acid–related orphan receptor gamma thymus (RORγt), on activities of cytochrome P450 (CYP) enzymes in healthy adults. Twenty study participants received a single oral dose of the modified Cooperstown 5+1 cocktail CYP probe drugs alone without cedirogant ...
Ronilda D'Cunha +8 more
wiley +1 more source
GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory
Comprehensive Physiology, Volume 16, Issue 2, April 2026.GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao +5 more
wiley +1 more source
Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source
Human Brain Mapping, Volume 47, Issue 5, 1 April 2026.Long‐term hearing loss with cognitive decline shows altered brain gradients, enlarged choroid plexus, and ventricles. These are linked to transcriptomic changes in synaptic, metabolic, and neurodegenerative pathways. ABSTRACT Long‐term sensorineural hearing loss (SNHL) is a prevalent condition associated with an increased risk of cognitive impairment ...
Xiao‐Min Xu +8 more
wiley +1 more source
Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. [PDF]
Psychopharmacology (Berl), 2018 Maggio SE +11 more
europepmc +1 more source
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT The number of newborns with neonatal opioid withdrawal syndrome is alarming, due to the increase in maternal opioid use. Despite the critical health and socio‐economic impact, a precise clinical and therapeutic approach for opioid using infants and mothers remains undefined.
José Miguel Pérez‐Jiménez +2 more
wiley +1 more source
Epilepsy: Molecular Pathogenesis and Emerging Therapies
MedComm, Volume 7, Issue 4, April 2026.Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Wanbin Huang +5 more
wiley +1 more source