Results 181 to 190 of about 21,014 (223)
Some of the next articles are maybe not open access.
Discriminative stimulus properties of the nicotinic agonist cytisine
Psychopharmacology, 1997Cytisine binds with high affinity and specificity to neuronal nicotinic receptors but its physiological and behavioural effects are complex and differ from those of nicotine. The present study explores the behavioural aspects further by comparing the discriminative stimulus effects of cystisine with those of nicotine. Two groups of rats were trained to
C J, Chandler, I P, Stolerman
openaire +2 more sources
NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE
Clinical and Experimental Pharmacology and Physiology, 1990SUMMARY1. The bronchomotor actions of three nicotinic cholinoceptor agonists were investigated in anaesthetized, mechanically ventilated cats. The agonists were administered intravenously after increasing baseline airways smooth muscle tone with an infusion of 5‐hydroxytryptamine.2.
D C, Thompson, R J, Altiere, L, Diamond
openaire +2 more sources
Neuronal nicotinic acetylcholine receptor agonists
Expert Opinion on Therapeutic Patents, 2004Nicotinic acetylcholine receptors (nAChRs) consist of five protein subunits surrounding a central ion channel.
TOMA, LUCIO +2 more
openaire +3 more sources
HM74a Agonists: Will they be the New Generation of Nicotinic Acid?
Current Topics in Medicinal Chemistry, 2009The discovery of HM74a as a high affinity receptor for nicotinic acid has opened up new areas for investigation. Since its discovery, several new chemical entities have been reported as HM74a agonists. One of them, MK-0354, has been tested in phase II studies, but despite significant decreases in Free Fatty Acid levels with absence of flushing events ...
openaire +2 more sources
Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.
The Journal of Pharmacology and Experimental Therapeutics, 1996The present experiments assessed the influence of nicotinic cholinergic receptors on latent inhibition (LI), which is the decrement in Pavlovian conditioning resulting from extensive preexposure to a conditioned stimulus (CS). LI was assessed within a conditioned emotional response paradigm involving three phases: preexposure [either 0 (nonpreexposed ...
J, Rochford, A P, Sen, R, Quirion
openaire +2 more sources
Neuronal Nicotinic Acetylcholine Receptor Agonists
Current Pharmaceutical Design, 1996In contrast to the considerable effort over many years to design agonists of the muscanmc acetylcholine receptor, until recently little attention has been directed towards agonists of the nicotinic family of acetylcholine receptors (NAChRs). Nevertheless, the structure and function of NAChRs has been a topic of intense research for several decades ...
Ian A. McDonald +3 more
openaire +1 more source
Epibatidine, a potent analgetic and nicotinic agonist.
Molecular Pharmacology, 1994Synthetic (+)- and (-)-epibatidine (an alkaloid originally characterized from frog skin) have potent analgetic activity in mice, using the hot-plate assay. The natural (+)-enantiomer, with an ED50 of about 1.5 micrograms/kg upon intraperitoneal injection, is about 2-fold more potent than the (-)-enantiomer.
B, Badio, J W, Daly
openaire +2 more sources
Agonist efficiency in a nicotinic receptor
Biophysical Journal, 2023Dinesh Indurthi, Anthony Auerbach
openaire +1 more source
Nicotinic Acid Receptor Agonists
Journal of Medicinal Chemistry, 2008P Douglas, Boatman +2 more
openaire +2 more sources
Epibatidine, a novel nicotinic receptor agonist
1994It is speculated that nicotine receptor ligands might be of therapeutic benefit for the treatment of obesity, anxiety, and memory loss. With the exception of nicotine, few selective high-affinity agents exist. (-)Epibatidine (1), isolated from Ecuadoran frogs, shows structural resemblence to (-)nicotine (2). Molecular modeling studies reveal that the N
M. Dukat +22 more
openaire +1 more source