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Agonists and Antagonists of Nicotinic Acetylcholine Receptors
2000 The natural alkaloids nicotine and muscarine (Fig. 1) were the key pharmacologic tools that uncovered the two families of acetylcholine (ACh) receptors in the CNS. These families were defined by the action of these alkaloids to mimic the multiplicity of effects of ACh as a mediator of synaptic transmission (TAYLOR 1996).S. P. Arneric, M. W. Holladayopenaire +1 more sourceABT — 418, a Novel Nicotinic Agonist
1994 With the plethora of receptor targets evolving as the result of nicotinic acetylcholine receptor (nAChR) cloning it is possible that new molecular entities selective for subtypes of nAChRs can be developed which are potentially free of the side effect liabilities associated with (-)-nicotine.S. P. Arneric, M. Williams, M. W. Holladay, J. T. Wasicak, D. Donnelly-Roberts, D. J. Anderson, P. Pavlik, Y. C. Martin, D. S. Garvey, J. P. Sullivan, G. Wilkie, Susan Wonnacott, S. F. Robinson, James R. Pauly, M. W. Decke, J. D. Brioni, M. J. Buckley, P. Curzon, A. B. O’Neill, D. J. B. Kim, M. Majchrzak, K. Marsh, S. Quigley, A. D. Rodrigues, R. Radek, J. J. Buccafusco, W. J. Jackson, A. V. Terry, K. C. Marsh, M. W. Decker, S. P. Amend, J. R. Pauly +31 moreopenaire +1 more sourceModulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists.
Ciba Foundation symposium, 1990 Although numerous studies have demonstrated that chronic nicotine treatment often results in tolerance to this drug, the mechanisms that underlie this tolerance are not well defined. Recent evidence suggests that chronic nicotine treatment results in an up-regulation of brain nicotinic receptors, but the majority of these receptors may be desensitized ...A C, Collins, R V, Bhat, J R, Pauly, M J, Marks +3 moreopenaire +1 more sourceNicotinic agonist and antagonist effects on memory
Drug Development Research, 1996 Nicotine has been found by a variety of investigators to improve memory in rats, monkeys, and humans. Recent studies have helped to determine the behavioral and pharmacological nature of critical nicotine effects on memory function. Other nicotinic agonists, including ABT-418, GTS-21, or lobeline, can also significantly improve memory performance ...openaire +1 more sourceNicotinic Agonists and Antagonists
2010 Anne M Andrews, Greg A Gerhardt, Lynette C. Daws, Mohammed Shoaib, Barbara J Mason, Charles J Heyser, Luis De Lecea, Robert L Balster, Sharon Walsh, Megan M. Dahmen, Jana Lincoln, Sheldon Preskorn, Roshan Cools, Maria Isabel Colado, Richard Green, Luis Stinus, Stéphanie Caillé, Martine Cador, Marie-Louise G. Wadenberg, Samuel G. Siris, Seiya Miyamoto, Alex Hofer, Linda P Spear, A. Claudio Cuello, A. Leslie Morrow, Patrizia Porcu, Marilyn E Carroll, Peter A Santi, Daniel Bertrand, Hans Rollema, Raymond S Hurst, Peter Riederer, Siegfried Hoyer, Wiepke Cahn, Heleen B M Boos, H D Postma, R. H. De Rijk, E. R Kloet, Sharon Morein-Zamir, Barbara J Sahakian, Peter Riederer, Siegfried Hoyer, J. M. Bessa, Osborne F. X. Almeida, N. Sousa, Wiepke Cahn, Heleen B M Boos, H D Postma, R. Andrew Chambers, Caroline Cohen, Marc Turiault, Guy Griebel, Caroline Cohen, Marc Turiault, Guy Griebel, Wolfgang Fleischhacker, Alfonso Abizaid, Shimon Amir, Jaanus Harro, Peter Verheart, Per Svenningsson, Per Andrén, R. Andrew Chambers, Kenneth J. Rhodes, A. Richard Green, Maria Isabel Colado, Maria Isabel Colado, Richard Green, Christof Baltes, Thomas Mueggler, Markus Rudin, Lucy C. Guillory, Becky Kinkead, Charles B. Nemeroff, Wiepke Cahn, Heleen B M Boos, H D Postma, Heleen B. M. Boos, H. D. Postma, Wiepke Cahn, Stephen B. Dunnett, Michael J Kuhar, Anne M Andrews, Greg A Gerhardt, Lynette Daws, Stephen Stahl, Meghan M Grady, Jean-Michel Scherrmann, Arthur Christopoulos, Gregory D Stewart, Patrick M Sexton, Jelena Nesic, Theodora Duka, Paul B.S. Clarke, Maxine L. Stitzer, Daniel Bertrand, Hans Rollema, Raymond S Hurst, Hans Rollema, Daniel Bertrand, Raymond S. Hurst, Paul Newhouse, Heather Wilkins, Lance Richard McMahon, Trevor W. Robbins, Robert L Balster, Robert L Balster, Patrizia Porcu, A Leslie Morrow, Becky Kinkead, Charles B Nemeroff, Lucy C Guillory, Stephen C Fowler, Jaime M. Monti, Daniel Monti, Malcolm Lader, Seithikurippu R Pandi-Perumal, Milton Kramer, Michael J Thorpy, Shelby Freedman Harris, D Warren Spence, Peter J Tyrer, Linda A Dykstra, Brian E. Leonard, E C Warburton, Michael Minzenberg, Michael Minzenberg, Ian Stolerman, Anne Jackson, Susan Jones, Ben J Harrison, Christos Pantelis, Tara L White, Richard Depue, Michael Bloch, James F Leckman, Christoph Correll +136 moreopenaire +1 more source
