Results 171 to 180 of about 21,014 (223)
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Nicotinic Agonists and Psychosis
Current Drug Target -CNS & Neurological Disorders, 2002Schizophrenia patients have insufficient inhibitory processing of identical paired auditory stimuli. This deficient "auditory gating" is thought to have physiological relevance, and its severity correlates with certain measures of both positive and negative symptoms.
J K, Simosky, K E, Stevens, R, Freedman
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Effects of nicotinic agonists on the NMDA receptor
Brain Research, 1991The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, were able to displace [3H]dizocilpine
E, Aizenman, L H, Tang, I J, Reynolds
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Attentional effects of nicotinic agonists in rats
Neuropharmacology, 2003Nicotine can increase stimulus detection, response rate and speed in the five-choice serial reaction time task, a rodent test of attention. In the present experiments, four other nicotinic agonists with different pharmacological profiles were compared in the same procedure.
Britta, Hahn +4 more
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Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors.
Molecular Pharmacology, 1989Isoarecolone methiodide (1-methyl-4-acetyl-1,2,3,6-tetrahydropyridine methiodide) was previously shown to be among the most potent agonists tested at the frog neuromuscular junction. Because nicotinic receptors from different sources vary in their selectivities, isoarecolone methiodide as well as 19 additional congeners, most of which were also ...
C E, Spivak, J A, Waters, R S, Aronstam
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Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist
Psychopharmacology, 1995ABT-418, a novel cholinergic ligand, was reported to possess potent cognitive-enhancing and anxiolytic properties in animal models with reduced side effects (Decker et al. 1994; Garvey et al. 1994) suggesting selectivity of effects. In this study, the binding properties of ABT-418 to [3H]-nicotine sites were evaluated and its pharmacology investigated ...
M I, Damaj +5 more
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Pharmacotherapy for tobacco cessation: Nicotine agonists, antagonists, and partial agonists
Current Oncology Reports, 2007Nicotine replacement therapies (NRT) were the main pharmacologic option for treatment of nicotine dependence until the early 1990s, when controlled clinical trials confirmed the efficacy of bupropion, the first treatment not based on nicotine. Varenicline, a partial agonist at nicotine receptors, gained US regulatory approval in 2006 for smoking ...
Maher, Karam-Hage, Paul M, Cinciripini
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Fluorescent Agonists for the Torpedo Nicotinic Acetylcholine Receptor
ChemBioChem, 2008AbstractWe have synthesized a series of fluorescent acylcholine derivatives carrying different linkers that vary in length and structure and connect the acylcholine unit to the environment‐sensitive fluorophores 7‐(diethylamino)coumarin‐3‐carbonyl (DEAC) or N‐(7‐nitrobenz‐2‐oxa‐1,3‐diazol‐yl) (NBD).
Krieger, F. +6 more
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The therapeutic potential of nicotine and nicotinic agonists for weight control
Expert Opinion on Investigational Drugs, 1999Transdermal nicotine patches have been successfully introduced as a safe and powerful aid to smoking cessation; this has contributed to the rising interest in additional therapeutic applications for nicotine and synthetic nicotinic agonists. Nicotine and nicotinic agonists may have a therapeutic potential for a variety of disorders, including Alzheimer'
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Nicotine effects on the activity of mice exposed prenatally to the nicotinic agonist anatoxin-a
Neurotoxicology and Teratology, 2005Anatoxin-a is a nicotinic agonist produced by several genera of cyanobacteria, and has caused numerous deaths of wildlife, livestock and domestic animals world-wide. Several studies in the literature have shown that exposure of mice and rats to nicotine early in development alters its effects when the rodents are subsequently challenged with nicotine ...
R C, Macphail +3 more
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Decamethonium is a partial agonist at the nicotinic acetylcholine receptor
Synapse, 1993AbstractThe efficacy of decamethonium as an agonist at the nicotinic acetylcholine receptor has never been determined. Here, we demonstrate how patch clamp recording during rapid perfusion of agonists to outside‐out patches from BC3H‐1 cells can be used to provide an unambiguous estimate of the efficacy of decamethonium.
Y, Liu, J P, Dilger
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