Results 271 to 280 of about 41,965 (298)

Attentional effects of nicotinic agonists in rats

Neuropharmacology, 2003
Nicotine can increase stimulus detection, response rate and speed in the five-choice serial reaction time task, a rodent test of attention. In the present experiments, four other nicotinic agonists with different pharmacological profiles were compared in the same procedure.
Britta, Hahn, Christopher G V, Sharples, Susan, Wonnacott, Mohammed, Shoaib, Ian P, Stolerman   +4 more
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NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE

Clinical and Experimental Pharmacology and Physiology, 1990
SUMMARY1. The bronchomotor actions of three nicotinic cholinoceptor agonists were investigated in anaesthetized, mechanically ventilated cats. The agonists were administered intravenously after increasing baseline airways smooth muscle tone with an infusion of 5‐hydroxytryptamine.2.
D C, Thompson, R J, Altiere, L, Diamond
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Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist

Psychopharmacology, 1995
ABT-418, a novel cholinergic ligand, was reported to possess potent cognitive-enhancing and anxiolytic properties in animal models with reduced side effects (Decker et al. 1994; Garvey et al. 1994) suggesting selectivity of effects. In this study, the binding properties of ABT-418 to [3H]-nicotine sites were evaluated and its pharmacology investigated ...
M I, Damaj, K R, Creasy, S P, Welch, J A, Rosecrans, M D, Aceto, B R, Martin   +5 more
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Fluorescent Agonists for the Torpedo Nicotinic Acetylcholine Receptor

ChemBioChem, 2008
AbstractWe have synthesized a series of fluorescent acylcholine derivatives carrying different linkers that vary in length and structure and connect the acylcholine unit to the environment‐sensitive fluorophores 7‐(diethylamino)coumarin‐3‐carbonyl (DEAC) or N‐(7‐nitrobenz‐2‐oxa‐1,3‐diazol‐yl) (NBD).
Krieger, F., Mourot, A., Araoz, R., Kotzyba-Hibert, F., Molgó , J., Bamberg, E., Goeldner, M.   +6 more
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ChemInform Abstract: Nicotinic Acid Receptor Agonists

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P. Douglas Boatman, Jeremy G. Richman, Graeme Semple   +2 more
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Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors.

Molecular Pharmacology, 1989
Isoarecolone methiodide (1-methyl-4-acetyl-1,2,3,6-tetrahydropyridine methiodide) was previously shown to be among the most potent agonists tested at the frog neuromuscular junction. Because nicotinic receptors from different sources vary in their selectivities, isoarecolone methiodide as well as 19 additional congeners, most of which were also ...
C E, Spivak, J A, Waters, R S, Aronstam
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7-Azaindole derivatives as potential partial nicotinic agonists

Bioorganic & Medicinal Chemistry Letters, 2008
We have investigated a series of 7-azaindoles as potential partial agonists of the alpha4beta2 nicotinic acetylcholine receptor (nAChR). Three series of 7-azaindole derivatives have been synthesized and evaluated for rat brain neuronal nicotinic receptor affinity and functional activity.
Axel R, Stoit, Arnold P, den Hartog, Harry, Mons, Sjoerd, van Schaik, Nynke, Barkhuijsen, Cees, Stroomer, Hein K A C, Coolen, Jan Hendrik, Reinders, Tiny J P, Adolfs, Martina, van der Neut, Hiskias, Keizer, Chris G, Kruse   +11 more
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The therapeutic potential of nicotine and nicotinic agonists for weight control

Expert Opinion on Investigational Drugs, 1999
Transdermal nicotine patches have been successfully introduced as a safe and powerful aid to smoking cessation; this has contributed to the rising interest in additional therapeutic applications for nicotine and synthetic nicotinic agonists. Nicotine and nicotinic agonists may have a therapeutic potential for a variety of disorders, including Alzheimer'
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Effects of nicotinic agonists on the NMDA receptor

Brain Research, 1991
The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, were able to displace [3H]dizocilpine
E, Aizenman, L H, Tang, I J, Reynolds
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ABT — 418, a Novel Nicotinic Agonist

1994
With the plethora of receptor targets evolving as the result of nicotinic acetylcholine receptor (nAChR) cloning it is possible that new molecular entities selective for subtypes of nAChRs can be developed which are potentially free of the side effect liabilities associated with (-)-nicotine.
S. P. Arneric, M. Williams, M. W. Holladay, J. T. Wasicak, D. Donnelly-Roberts, D. J. Anderson, P. Pavlik, Y. C. Martin, D. S. Garvey, J. P. Sullivan, G. Wilkie, Susan Wonnacott, S. F. Robinson, James R. Pauly, M. W. Decke, J. D. Brioni, M. J. Buckley, P. Curzon, A. B. O’Neill, D. J. B. Kim, M. Majchrzak, K. Marsh, S. Quigley, A. D. Rodrigues, R. Radek, J. J. Buccafusco, W. J. Jackson, A. V. Terry, K. C. Marsh, M. W. Decker, S. P. Amend, J. R. Pauly   +31 more
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