Results 291 to 300 of about 493,465 (339)
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Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors.
Molecular Pharmacology, 1989Isoarecolone methiodide (1-methyl-4-acetyl-1,2,3,6-tetrahydropyridine methiodide) was previously shown to be among the most potent agonists tested at the frog neuromuscular junction. Because nicotinic receptors from different sources vary in their selectivities, isoarecolone methiodide as well as 19 additional congeners, most of which were also ...
C E, Spivak, J A, Waters, R S, Aronstam
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Attentional effects of nicotinic agonists in rats
Neuropharmacology, 2003Nicotine can increase stimulus detection, response rate and speed in the five-choice serial reaction time task, a rodent test of attention. In the present experiments, four other nicotinic agonists with different pharmacological profiles were compared in the same procedure.
Britta, Hahn +4 more
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Pharmacotherapy for tobacco cessation: Nicotine agonists, antagonists, and partial agonists
Current Oncology Reports, 2007Nicotine replacement therapies (NRT) were the main pharmacologic option for treatment of nicotine dependence until the early 1990s, when controlled clinical trials confirmed the efficacy of bupropion, the first treatment not based on nicotine. Varenicline, a partial agonist at nicotine receptors, gained US regulatory approval in 2006 for smoking ...
Maher, Karam-Hage, Paul M, Cinciripini
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The therapeutic potential of nicotine and nicotinic agonists for weight control
Expert Opinion on Investigational Drugs, 1999Transdermal nicotine patches have been successfully introduced as a safe and powerful aid to smoking cessation; this has contributed to the rising interest in additional therapeutic applications for nicotine and synthetic nicotinic agonists. Nicotine and nicotinic agonists may have a therapeutic potential for a variety of disorders, including Alzheimer'
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Nicotine effects on the activity of mice exposed prenatally to the nicotinic agonist anatoxin-a
Neurotoxicology and Teratology, 2005Anatoxin-a is a nicotinic agonist produced by several genera of cyanobacteria, and has caused numerous deaths of wildlife, livestock and domestic animals world-wide. Several studies in the literature have shown that exposure of mice and rats to nicotine early in development alters its effects when the rodents are subsequently challenged with nicotine ...
R C, Macphail +3 more
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Decamethonium is a partial agonist at the nicotinic acetylcholine receptor
Synapse, 1993AbstractThe efficacy of decamethonium as an agonist at the nicotinic acetylcholine receptor has never been determined. Here, we demonstrate how patch clamp recording during rapid perfusion of agonists to outside‐out patches from BC3H‐1 cells can be used to provide an unambiguous estimate of the efficacy of decamethonium.
Y, Liu, J P, Dilger
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Discriminative stimulus properties of the nicotinic agonist cytisine
Psychopharmacology, 1997Cytisine binds with high affinity and specificity to neuronal nicotinic receptors but its physiological and behavioural effects are complex and differ from those of nicotine. The present study explores the behavioural aspects further by comparing the discriminative stimulus effects of cystisine with those of nicotine. Two groups of rats were trained to
C J, Chandler, I P, Stolerman
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Fluorescent Agonists for the Torpedo Nicotinic Acetylcholine Receptor
ChemBioChem, 2008AbstractWe have synthesized a series of fluorescent acylcholine derivatives carrying different linkers that vary in length and structure and connect the acylcholine unit to the environment‐sensitive fluorophores 7‐(diethylamino)coumarin‐3‐carbonyl (DEAC) or N‐(7‐nitrobenz‐2‐oxa‐1,3‐diazol‐yl) (NBD).
Florian, Krieger +6 more
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NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE
Clinical and Experimental Pharmacology and Physiology, 1990SUMMARY1. The bronchomotor actions of three nicotinic cholinoceptor agonists were investigated in anaesthetized, mechanically ventilated cats. The agonists were administered intravenously after increasing baseline airways smooth muscle tone with an infusion of 5‐hydroxytryptamine.2.
D C, Thompson, R J, Altiere, L, Diamond
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HM74a Agonists: Will they be the New Generation of Nicotinic Acid?
Current Topics in Medicinal Chemistry, 2009The discovery of HM74a as a high affinity receptor for nicotinic acid has opened up new areas for investigation. Since its discovery, several new chemical entities have been reported as HM74a agonists. One of them, MK-0354, has been tested in phase II studies, but despite significant decreases in Free Fatty Acid levels with absence of flushing events ...
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