Results 301 to 310 of about 493,465 (339)

Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.

The Journal of Pharmacology and Experimental Therapeutics, 1996
The present experiments assessed the influence of nicotinic cholinergic receptors on latent inhibition (LI), which is the decrement in Pavlovian conditioning resulting from extensive preexposure to a conditioned stimulus (CS). LI was assessed within a conditioned emotional response paradigm involving three phases: preexposure [either 0 (nonpreexposed ...
J, Rochford, A P, Sen, R, Quirion
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Neuronal Nicotinic Acetylcholine Receptor Agonists

Current Pharmaceutical Design, 1996
In contrast to the considerable effort over many years to design agonists of the muscanmc acetylcholine receptor, until recently little attention has been directed towards agonists of the nicotinic family of acetylcholine receptors (NAChRs). Nevertheless, the structure and function of NAChRs has been a topic of intense research for several decades ...
Ian A. McDonald, Jean-Michel Vernier, Nicholas Cosford, Janis Corey-Naeve   +3 more
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Epibatidine, a potent analgetic and nicotinic agonist.

Molecular Pharmacology, 1994
Synthetic (+)- and (-)-epibatidine (an alkaloid originally characterized from frog skin) have potent analgetic activity in mice, using the hot-plate assay. The natural (+)-enantiomer, with an ED50 of about 1.5 micrograms/kg upon intraperitoneal injection, is about 2-fold more potent than the (-)-enantiomer.
B, Badio, J W, Daly
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Neuronal nicotinic acetylcholine receptor agonists

Expert Opinion on Therapeutic Patents, 2004
Nicotinic acetylcholine receptors (nAChRs) consist of five protein subunits surrounding a central ion channel.
TOMA, LUCIO, BARLOCCO Daniela, GELAIN Arianna   +2 more
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Agonist efficiency in a nicotinic receptor

Biophysical Journal, 2023
Dinesh Indurthi, Anthony Auerbach
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ABT — 418, a Novel Nicotinic Agonist

1994
With the plethora of receptor targets evolving as the result of nicotinic acetylcholine receptor (nAChR) cloning it is possible that new molecular entities selective for subtypes of nAChRs can be developed which are potentially free of the side effect liabilities associated with (-)-nicotine.
S. P. Arneric, M. Williams, M. W. Holladay, J. T. Wasicak, D. Donnelly-Roberts, D. J. Anderson, P. Pavlik, Y. C. Martin, D. S. Garvey, J. P. Sullivan, G. Wilkie, Susan Wonnacott, S. F. Robinson, James R. Pauly, M. W. Decke, J. D. Brioni, M. J. Buckley, P. Curzon, A. B. O’Neill, D. J. B. Kim, M. Majchrzak, K. Marsh, S. Quigley, A. D. Rodrigues, R. Radek, J. J. Buccafusco, W. J. Jackson, A. V. Terry, K. C. Marsh, M. W. Decker, S. P. Amend, J. R. Pauly   +31 more
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Nicotinic Acid Receptor Agonists

Journal of Medicinal Chemistry, 2008
P Douglas, Boatman, Jeremy G, Richman, Graeme, Semple   +2 more
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Epibatidine, a novel nicotinic receptor agonist

1994
It is speculated that nicotine receptor ligands might be of therapeutic benefit for the treatment of obesity, anxiety, and memory loss. With the exception of nicotine, few selective high-affinity agents exist. (-)Epibatidine (1), isolated from Ecuadoran frogs, shows structural resemblence to (-)nicotine (2). Molecular modeling studies reveal that the N
M. Dukat, D. Dumas, M. I. Damaj, W. Glassco, E. L. May, B. R. Martin, R. A. Glennon, D. M. Wypij, T. Y. Shen, K. R. Creasy, J. Rosecrans, J. P. Sullivan, A. W. Bannon, D. Donnelly-Roberts, D. J. Anderson, M. Piattoni-Kaplan, M. Gopalakrishnan, M. W. Decker, S. P. Arneric, R. Loring, T. McHugh, X. Zhang, J. McKay   +22 more
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Nicotinic agonist and antagonist effects on memory

Drug Development Research, 1996
Nicotine has been found by a variety of investigators to improve memory in rats, monkeys, and humans. Recent studies have helped to determine the behavioral and pharmacological nature of critical nicotine effects on memory function. Other nicotinic agonists, including ABT-418, GTS-21, or lobeline, can also significantly improve memory performance ...
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Agonists and Antagonists of Nicotinic Acetylcholine Receptors

2000
The natural alkaloids nicotine and muscarine (Fig. 1) were the key pharmacologic tools that uncovered the two families of acetylcholine (ACh) receptors in the CNS. These families were defined by the action of these alkaloids to mimic the multiplicity of effects of ACh as a mediator of synaptic transmission (TAYLOR 1996).
S. P. Arneric, M. W. Holladay
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