Results 311 to 320 of about 484,958 (335)
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Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists.
Ciba Foundation symposium, 1990Although numerous studies have demonstrated that chronic nicotine treatment often results in tolerance to this drug, the mechanisms that underlie this tolerance are not well defined. Recent evidence suggests that chronic nicotine treatment results in an up-regulation of brain nicotinic receptors, but the majority of these receptors may be desensitized ...
James R. Pauly +3 more
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HM74a Agonists: Will they be the New Generation of Nicotinic Acid?
Current Topics in Medicinal Chemistry, 2009The discovery of HM74a as a high affinity receptor for nicotinic acid has opened up new areas for investigation. Since its discovery, several new chemical entities have been reported as HM74a agonists. One of them, MK-0354, has been tested in phase II studies, but despite significant decreases in Free Fatty Acid levels with absence of flushing events ...
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Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.
The Journal of Pharmacology and Experimental Therapeutics, 1996The present experiments assessed the influence of nicotinic cholinergic receptors on latent inhibition (LI), which is the decrement in Pavlovian conditioning resulting from extensive preexposure to a conditioned stimulus (CS). LI was assessed within a conditioned emotional response paradigm involving three phases: preexposure [either 0 (nonpreexposed ...
J, Rochford, A P, Sen, R, Quirion
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Nicotinic agonist and antagonist effects on memory
Drug Development Research, 1996Nicotine has been found by a variety of investigators to improve memory in rats, monkeys, and humans. Recent studies have helped to determine the behavioral and pharmacological nature of critical nicotine effects on memory function. Other nicotinic agonists, including ABT-418, GTS-21, or lobeline, can also significantly improve memory performance ...
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Effects of isoarecolone, a nicotinic receptor agonist in rodent models of nicotine dependence
Psychopharmacology, 2006The nicotinic receptor agonist, isoarecolone, has 'nicotine-like' subjective properties as detected by rats in a discrimination paradigm. However, isoarecolone lacks the intra-accumbens dopamine-releasing effects, a feature akin to most abused substances.
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Journal of Natural Products, 2003
Analytical HPLC fractionation, combined with an off-line 96-well fluorescent bioassay screen, has been developed and used for the separation and screening of a natural product extract.
R. Fitch +4 more
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Analytical HPLC fractionation, combined with an off-line 96-well fluorescent bioassay screen, has been developed and used for the separation and screening of a natural product extract.
R. Fitch +4 more
semanticscholar +1 more source
Nicotine receptor partial agonists for alcohol dependence
Cochrane Database of Systematic Reviews, 2011Reason for withdrawal from publication This protocol is withdrawn because authors did not find time to finish the review within adequate deadlines.
Susanna Galea +5 more
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Agonists and Antagonists of Nicotinic Acetylcholine Receptors
2000The natural alkaloids nicotine and muscarine (Fig. 1) were the key pharmacologic tools that uncovered the two families of acetylcholine (ACh) receptors in the CNS. These families were defined by the action of these alkaloids to mimic the multiplicity of effects of ACh as a mediator of synaptic transmission (TAYLOR 1996).
M. W. Holladay, S. P. Arneric
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