Results 41 to 50 of about 41,965 (298)

Sulfonium Ligands of the α7 nAChR

Molecules, 2021
The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor are ...
Nicole A. Horenstein, Clare Stokes, Roger L. Papke   +2 more
doaj   +1 more source

Agonist activation of a nicotinic acetylcholine receptor [PDF]

Neuropharmacology, 2015
How does an agonist activate a receptor? In this article I consider the activation process in muscle nicotinic acetylcholine receptors (AChRs), a prototype for understanding the energetics of binding and gating in other ligand-gated ion channels. Just as movements that generate gating currents activate voltage-gated ion channels, movements at binding ...
openaire   +2 more sources

Critical Role of CA1 Nicotinic Receptors on Memory Acquisition Deficit Under Induction of Total Sleep Deprivation and REM Sleep Deprivation

International Clinical Neuroscience Journal, 2018
Background: Sleep disorder or sleep deprivation (SD) is a common issue in today’s society. Numerous evidences show that sleep is essential for proper brain performance and cognitive processes; on the other hand, cognitive functions have a broad range ...
Bibi-Zahra Javad-Moosavi, Gholamhassan Vaezi, Mohammad Nasehi, Seyed-Ali Haeri-Rouhani, Mohammad-Reza Zarrindast   +4 more
doaj   +1 more source

Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells [PDF]

, 2018
Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood.
Grau, Veronika, Koch, Christian, Magel, Ilona, McIntosh, J. Michael, Padberg, Winfried, Perniss, Alexander, Richter, Katrin, Sander, Michael, Schweda, Elke K. H., Wichmann, Sven, Wilker, Sigrid, Wolf, Philipp M.   +11 more
core   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine [PDF]

, 2013
Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA).
A Taly, AA Grace, AJ Yu, AO Komendantov, AR Tapper, B Buisson, B Katz, Boris Gutkin, C Lüscher, C Shelley, CP Fenster, DB Carr, E Lichtenstein, E Sher, EJ Nestler, F Marti, FE Pontieri, G Di Chiara, G Di Chiara, G Di Chiara, GL Forster, HD Mansvelder, HD Mansvelder, HR Wilson, IW Jones, J Cornwall, J Grenhoff, JA Dani, Ja Dani, JB Eaton, JE Henningfield, JE Rose, JN Reynolds, JP Changeux, JP Changeux, JP Changeux, JR Clements, JR Wooltorton, K Chergui, Karl J. Friston, KG Paradiso, LE Chavez-Noriega, M Gao, M Garzón, M Graupner, M Mameli-Engvall, M Wu, MG Lacey, Michael Graupner, MJ Christie, MR Picciotto, MR Picciotto, N Champtiaux, P Dayan, PW Kalivas, R Exley, R Giniatullin, R Klink, R Nashmi, Reinoud Maex, RL Papke, S Erhardt, S Ikemoto, S Tolu, SA Oakman, SC Steffensen, SR Grady, SR Sesack, SW Johnson, SW Johnson, TC Jhou, V David, V Gerzanich, V Gerzanich, VI Pidoplichko, WA Corrigall, X Peng, ZM Fagen, ZY Tong   +78 more
core   +6 more sources

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

eLife, 2022
Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively than ...
Noah M Dietzen, Mark J Arcario, Lawrence J Chen, John T Petroff II, K Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F Covey, Wayland WL Cheng   +8 more
doaj   +1 more source

CB2R agonist prevents nicotine induced lung fibrosis

Experimental Lung Research, 2018
Nicotine stimulates fibroblast proliferation while increasing inflammation and fibrosis of tissues. The cannabinoid receptor 1 (CB1R) is mainly located in the CNS, while cannabinoid receptor 2 (CB2R) is located in the immune cells within the body. CB2R regulates inflammatory processes and fibroblast function.We investigated the impact of CB2R agonist ...
Ewelina, Wawryk-Gawda, Katarzyna, Chłapek, Michał K, Zarobkiewicz, Marta, Lis-Sochocka, Patrycja, Chylińska-Wrzos, Anna, Boguszewska-Czubara, Mirosław A, Sławiński, Anna, Franczak, Barbara, Jodłowska-Jędrych, Grażyna, Biała   +9 more
openaire   +3 more sources

Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists [PDF]

British Journal of Pharmacology, 1999
The dose‐response parameters of recombinant mouse adult neuromuscular acetylcholine receptor channels (nAChR) activated by carbamylcholine, nicotine, muscarine and oxotremorine were measured. Rate constants for agonist association and dissociation, and channel opening and closing, were estimated from single‐channel kinetic analysis.
G, Akk, A, Auerbach
openaire   +2 more sources

Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the WHO pharmacovigilance database

Arthritis &Rheumatology, Accepted Article.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportionality/clustering analysis from the WHO pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source