Results 41 to 50 of about 2,143 (224)
Suppression of methamphetamine-seeking behavior by nicotinic agonists [PDF]
Proceedings of the National Academy of Sciences, 2006 To understand the mechanism of methamphetamine (MAP) craving from the viewpoint of nicotinic acetylcholinergic transmission, we examined the responsible site of the brain for anticraving effects produced by nicotinic agonists by using a MAP self-administration paradigm in rats.
Katsuya Sakimura +4 more
openaire +3 more sources
Wareniklina – częściowy agonista receptorów nikotynowych w terapii zespołu uzależnienia od alkoholu
Alcoholism and Drug Addiction, 2016 The pharmacotherapy currently used for alcohol dependence may reduce alcohol consumption and extend abstinence periods. However, it is effective in only about 30% of addicted subjects.
Natalia Obsada +1 more
doaj +1 more source
Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. [PDF]
PLoS ONE, 2014 Three recently discovered tentacle muscles are crucial to perform patterned movements of upper tentacles of the terrestrial snail, Helix pomatia. The muscles receive central and peripheral excitatory cholinergic innervation lacking inhibitory innervation.
Tibor Kiss +3 more
doaj +1 more source
The Nicotinic Agonist Cytisine: The Role of the NH···N Interaction
The Journal of Physical Chemistry Letters, 2022 We report a detailed structural study of cytisine, an alkaloid used to help with smoking cessation, looking forward to unveiling its role as a nicotinic agonist. High-resolution rotational spectroscopy has allowed us to characterize two different conformers exhibiting axial and equatorial arrangements of the piperidinic NH group.
Raúl Aguado +5 more
openaire +3 more sources
Medicina, 2015 Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas +2 more
doaj +1 more source
Neuroreceptor Activation by Vibration-Assisted Tunneling [PDF]
Scientific Reports 5, Article number: 9990 Published 2015, 2015 G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous ...
arxiv +1 more source
International Clinical Neuroscience Journal, 2018 Background: Sleep disorder or sleep deprivation (SD) is a common issue in today’s society. Numerous evidences show that sleep is essential for proper brain performance and cognitive processes; on the other hand, cognitive functions have a broad range ...
Bibi-Zahra Javad-Moosavi +4 more
doaj +1 more source
eLife, 2022 Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively than ...
Noah M Dietzen +8 more
doaj +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2020 Nicotinic acetylcholine receptors are an important class of excitatory receptors in the central nervous system of arthropods. In the ticks Ixodes ricinus, the functional and pharmacological properties of nicotinic receptors located in their neurons are ...
Anaïs Le Mauff +8 more
doaj
Data in Brief, 2020 This manuscript is a companion paper to Ulleryd M.U. et al., “Stimulation of alpha 7 nicotinic acetylcholine receptor (α7nAChR) inhibits atherosclerosis via immunomodulatory effects on myeloid cells” Atherosclerosis, 2019 [1]. Data shown here include RNA
Marcus A. Ulleryd +10 more
doaj