Results 41 to 50 of about 465,771 (187)

A comparative study on the effects of nicotine and GTS-21, a new nicotinic agonist, on the locomotor activity and brain monoamine level.

Japanese Journal of Pharmacology, 1998
Effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], a selective nicotinic agonist, on locomotor activity and dopamine turnover were examined and compared to those of nicotine to test if GTS-21 exhibits side effects similar to ...
M. Nanri, N. Kasahara, Jyunji Yamamoto, Hidekazu Miyake, Hiroshi Watanabe   +4 more
semanticscholar   +1 more source

Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E₂ in rat microglial cultures

Journal of Neuroinflammation, 2005
Background Nicotinic acetylcholine (Ach) receptors are ligand-gated pentameric ion channels whose main function is to transmit signals for the neurotransmitter Ach in peripheral and central nervous system.
Minghetti Luisa, Carnevale Daniela, Ajmone-Cat Maria, De Simone Roberta   +3 more
doaj   +1 more source

Achieving maximal speed of solution exchange for patch clamp experiments. [PDF]

PLoS ONE, 2012
BACKGROUND: Resolving the kinetics of agonist binding events separately from the subsequent channel gating processes requires the ability of applying and removing the agonist before channel gating occurs.
Jerónimo Auzmendi, Darío Fernández Do Porto, Carla Pallavicini, Luciano Moffatt   +3 more
doaj   +1 more source

GTS-21, a nicotinic agonist, attenuates multiple infarctions and cognitive deficit caused by permanent occlusion of bilateral common carotid arteries in rats.

Japanese Journal of Pharmacology, 1998
We examined the effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], a nicotinic agonist, on histopathological changes of the brain and radial maze learning performance in rats with permanent occlusion of the bilateral common ...
M. Nanri, H. Miyake, Y. Murakami, Kinzo Matsumoto, H. Watanabe   +4 more
semanticscholar   +1 more source

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies

Nature Communications, 2023
The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7
Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean de la Bâtie, Stéphanie Pons, Gabriel Ayme, Patrick England, Marc Gielen, François Bontems, Gérard Pehau-Arnaudet, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer   +11 more
doaj   +1 more source

High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. [PDF]

PLoS ONE, 2016
High throughput random mutagenesis is a powerful tool to identify which residues are important for the function of a protein, and gain insight into its structure-function relation.
Paul J Groot-Kormelink, Sandrine Ferrand, Nicholas Kelley, Anke Bill, Felix Freuler, Pierre-Eloi Imbert, Anthony Marelli, Nicole Gerwin, Lucia G Sivilotti, Loren Miraglia, Anthony P Orth, Edward J Oakeley, Ulrich Schopfer, Sandra Siehler   +13 more
doaj   +1 more source

Defining nicotinic agonist binding surfaces through photoaffinity labeling.

Biochemistry, 2007
Nicotinic acetylcholine (ACh) receptor (nAChR) agonists are potential therapeutic agents for neurological dysfunction. In the present study, the homopentameric mollusk ACh binding protein (AChBP), used as a surrogate for the extracellular ligand-binding ...
M. Tomizawa, D. Maltby, K. Medzihradszky, Nanjing Zhang, K. A. Durkin, J. Presley, T. Talley, P. Taylor, A. Burlingame, J. Casida   +9 more
semanticscholar   +1 more source

Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues

Molecules, 2019
Neuronal α4β2 nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels (LGIC) that have been implicated in nicotine addiction, reward, cognition, pain disorders, anxiety, and depression.
Juan Pablo Gonzalez-Gutierrez, Martin Hodar, Franco Viscarra, Pablo Paillali, Nicolás Guerra-Díaz, Hernán Pessoa-Mahana, Juan José Hernández-Morantes, Horacio Pérez-Sánchez, Isabel Bermúdez, Miguel Reyes-Parada, Patricio Iturriaga-Vásquez   +10 more
doaj   +1 more source

Varenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease

Basic and Clinical Neuroscience, 2011
Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall.
Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Narges karimi, Mitra kamran   +3 more
doaj  

Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats

International Journal of Inflammation, 2016
Nicotine is protective in ulcerative colitis but not Crohn’s disease of the small intestine, but little is known about the effects of nicotine on Clostridium difficile toxin A-induced enteritis.
Steven R. Vigna
doaj   +1 more source