Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism [PDF]
, 2010 Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing α4 and β2 subunits (α4β2*) functionally interact with G-protein-coupled dopamine (DA) D_2 receptors in basal ganglia.
Andrew R. Tapper +18 more
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The effect of amixin and agmatine on cytochrome c release from isolated mitochondria [PDF]
The Ukrainian Biochemical Journal, 2017 Mitochondrial nicotinic acetylcholine receptors (nAChRs) control permeability transition pore formation and cytochrome c release in the presence of apoptogenic factors.
K. R. Uspenska +3 more
doaj +1 more source
Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development. [PDF]
, 2013 RationaleImpaired cognitive abilities are a key characteristic of schizophrenia. Although currently approved pharmacological treatments have demonstrated efficacy for positive symptoms, to date no pharmacological treatments successfully reverse cognitive
Acheson, Dean T +2 more
core +2 more sources
Agonist activation of a nicotinic acetylcholine receptor [PDF]
Neuropharmacology, 2015 How does an agonist activate a receptor? In this article I consider the activation process in muscle nicotinic acetylcholine receptors (AChRs), a prototype for understanding the energetics of binding and gating in other ligand-gated ion channels. Just as movements that generate gating currents activate voltage-gated ion channels, movements at binding ...
openaire +3 more sources
Frontiers in Immunology, 2018 Blood levels of the acute phase reactant C-reactive protein (CRP) are frequently measured as a clinical marker for inflammation, but the biological functions of CRP are still controversial.
Katrin Richter +22 more
doaj +1 more source
Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists [PDF]
British Journal of Pharmacology, 1999 The dose‐response parameters of recombinant mouse adult neuromuscular acetylcholine receptor channels (nAChR) activated by carbamylcholine, nicotine, muscarine and oxotremorine were measured. Rate constants for agonist association and dissociation, and channel opening and closing, were estimated from single‐channel kinetic analysis.
Gustav Akk, Anthony Auerbach
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Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning [PDF]
The EMBO Journal 27, 9 (2008) 1321-1332, 2008 The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G proteins.
arxiv +1 more source
Neural signatures of cognitive flexibility and reward sensitivity following nicotinic receptor stimulation in dependent smokers : a randomized trial [PDF]
, 2017 IMPORTANCE Withdrawal from nicotine is an important contributor to smoking relapse. Understanding how reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine replacement therapy and varenicline tartrate may aid ...
Aronson, Sarah E. +5 more
core +2 more sources
Silent agonists for α7 nicotinic acetylcholine receptors
Pharmacological Research, 2023 We discuss models for the activation and desensitization of α7 nicotinic acetylcholine receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators (PAMs) that destabilize α7 desensitized states. Type II PAMs such as PNU-120596 can be used to distinguish inactive compounds from silent agonists, compounds that produce little ...
Roger L. Papke +2 more
openaire +3 more sources
Frontiers in Neuroanatomy, 2017 Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and ...
Mohammed Z. Ariffin +4 more
doaj +1 more source