Results 71 to 80 of about 41,965 (298)

Expression of the α7 nicotinic acetylcholine receptor in human lung cells

Respiratory Research, 2005
Background We and others have shown that one of the mechanisms of growth regulation of small cell lung cancer cell lines and cultured pulmonary neuroendocrine cells is by the binding of agonists to the α7 neuronal nicotinic acetylcholine receptor.
Schuller Hildegard M, Dhar Madhu, Plummer Howard K   +2 more
doaj   +1 more source

Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. [PDF]

PLoS ONE, 2013
In the pentameric ligand-gated ion channel family, transmitter binds in the extracellular domain and conformational changes result in channel opening in the transmembrane domain.
Gustav Akk, Megan Eaton, Ping Li, Steven Zheng, Joshua Lo, Joe Henry Steinbach   +5 more
doaj   +1 more source

Suppression of methamphetamine-seeking behavior by nicotinic agonists [PDF]

Proceedings of the National Academy of Sciences, 2006
To understand the mechanism of methamphetamine (MAP) craving from the viewpoint of nicotinic acetylcholinergic transmission, we examined the responsible site of the brain for anticraving effects produced by nicotinic agonists by using a MAP self-administration paradigm in rats.
Takato, Hiranita, Yoko, Nawata, Katsuya, Sakimura, Kusnandar, Anggadiredja, Tsuneyuki, Yamamoto   +4 more
openaire   +2 more sources

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels [PDF]

, 2013
The mechanisms of allosteric action within pentameric ligand-gated ion channels (pLGICs) remain to be determined. Using crystallography, site-directed mutagenesis, and two-electrode voltage clamp measurements, we identified two functionally relevant ...
Chen, Q, Liang, J, Liang, Y, Mowrey, D, Tang, P, Xu, Y   +5 more
core   +3 more sources

Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E₂ in rat microglial cultures

Journal of Neuroinflammation, 2005
Background Nicotinic acetylcholine (Ach) receptors are ligand-gated pentameric ion channels whose main function is to transmit signals for the neurotransmitter Ach in peripheral and central nervous system.
Minghetti Luisa, Carnevale Daniela, Ajmone-Cat Maria, De Simone Roberta   +3 more
doaj   +1 more source

Nicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors [PDF]

Journal of Biological Chemistry, 2007
Nicotinic acid remains the most effective therapeutic agent for the treatment and prevention of atherosclerosis resulting from low high density lipoprotein cholesterol. The therapeutic actions of nicotinic acid are mediated by GPR109A, a Gi protein-coupled receptor, expressed primarily on adipocytes, Langerhans cells, and macrophage.
Jeremy G, Richman, Martha, Kanemitsu-Parks, Ibragim, Gaidarov, Jill S, Cameron, Peter, Griffin, Hong, Zheng, Nuvia C, Guerra, Linda, Cham, Dominique, Maciejewski-Lenoir, Dominic P, Behan, Doug, Boatman, Ruoping, Chen, Philip, Skinner, Pricilla, Ornelas, M Gerard, Waters, Samuel D, Wright, Graeme, Semple, Daniel T, Connolly   +17 more
openaire   +2 more sources

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

Identification of critical residues in loop E in the 5-HT(3AS)R binding site [PDF]

, 2002
BACKGROUND: The serotonin type 3 receptor (5-HT(3)R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably significant structural similarity.
Joshi, Prasad R, Muthalagi, Mani, Schulte, Marvin K, Venkatachalan, Srinivasan P, Venkataraman, Padmavati   +4 more
core   +3 more sources

Achieving maximal speed of solution exchange for patch clamp experiments. [PDF]

PLoS ONE, 2012
BACKGROUND: Resolving the kinetics of agonist binding events separately from the subsequent channel gating processes requires the ability of applying and removing the agonist before channel gating occurs.
Jerónimo Auzmendi, Darío Fernández Do Porto, Carla Pallavicini, Luciano Moffatt   +3 more
doaj   +1 more source