Results 71 to 80 of about 2,143 (224)

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Antiamnesic activity of the nicotinic agonist DBO-83 in mice [PDF]

Drug Development Research, 1998
The effect of administration of DBO-83 on memory processes was evaluated in the mouse passive avoidance test. DBO-83 (1–5 mgkg–1 ip) prevented amnesia induced by scopolamine (1.5 mgkg–1 ip), mecamylamine (20 mgkg–1 ip) and dihydro-β-erythroidine (10 μg per mouse i.c.v.). In the same experimental conditions, DBO-83 (10 mgkg–1 ip) also prevented baclofen
GHELARDINI, CARLA, GALEOTTI, NICOLETTA, F. GIULIANI, D. BARLOCCO, BARTOLINI, ALESSANDRO   +4 more
openaire   +3 more sources

Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review

Movement Disorders, EarlyView.
Abstract Objective To update evidence‐based medicine recommendations for treating motor fluctuations of Parkinson's disease (PD). Background The International Parkinson and Movement Disorder Society (MDS) Evidence Based Medicine in Movement Disorders Committee recommendations for the treatments of PD were first published in 2002 and regularly updated ...
Rob M.A. de Bie, Regina Katzenschlager, Bart E.K.S. Swinnen, Marina Peball, Shen‐Yang Lim, Tiago A. Mestre, Santiago Perez Lloret, Miguel Coelho, Camila Aquino, Ai Huey Tan, Veronica Bruno, Joke M. Dijk, Beatrice Heim, Chin‐Hsien Lin, Linda Azevedo Kauppila, Irene Litvan, René Spijker, Klaus Seppi, João Costa, Cristina Sampaio, Susan H. Fox, Monty A. Silverdale   +21 more
wiley   +1 more source

Generative artificial intelligence-enabled dynamic detection of nicotine-related circuits [PDF]

arXiv, 2022
The identification of addiction-related circuits is critical for explaining addiction processes and developing addiction treatments. And models of functional addiction circuits developed from functional imaging are an effective tool for discovering and verifying addiction circuits.
arxiv  

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues

Molecules, 2019
Neuronal α4β2 nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels (LGIC) that have been implicated in nicotine addiction, reward, cognition, pain disorders, anxiety, and depression.
Juan Pablo Gonzalez-Gutierrez, Martin Hodar, Franco Viscarra, Pablo Paillali, Nicolás Guerra-Díaz, Hernán Pessoa-Mahana, Juan José Hernández-Morantes, Horacio Pérez-Sánchez, Isabel Bermúdez, Miguel Reyes-Parada, Patricio Iturriaga-Vásquez   +10 more
doaj   +1 more source

High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. [PDF]

PLoS ONE, 2016
High throughput random mutagenesis is a powerful tool to identify which residues are important for the function of a protein, and gain insight into its structure-function relation.
Paul J Groot-Kormelink, Sandrine Ferrand, Nicholas Kelley, Anke Bill, Felix Freuler, Pierre-Eloi Imbert, Anthony Marelli, Nicole Gerwin, Lucia G Sivilotti, Loren Miraglia, Anthony P Orth, Edward J Oakeley, Ulrich Schopfer, Sandra Siehler   +13 more
doaj   +1 more source

Estimating Longitudinal Causal Effects with Unobserved Noncompliance Using a Semi-Parametric G-computation Algorithm [PDF]

arXiv, 2023
Participant noncompliance, in which participants do not follow their assigned treatment protocol, often obscures the causal relationship between treatment and treatment effect in randomized trials. In the longitudinal setting, the G-computation algorithm can adjust for confounding to estimate causal effects. Typically, G-computation assumes that both 1)
arxiv  

Activation of endplate nicotinic acetylcholine receptors by agonists [PDF]

Biochemical Pharmacology, 2015
The interaction of a small molecule made in one cell with a large receptor made in another is the signature event of cell signaling. Understanding the structure and energy changes associated with agonist activation is important for engineering drugs, receptors and synapses.
openaire   +2 more sources

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source