Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder
Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley +1 more source
GLP‐1RA use improves outcomes post partial nephrectomy in T2DM patients with RCC: A TriNetX study
BJUI Compass, Volume 7, Issue 2, February 2026.Abstract Objectives The purpose of this study is to investigate the impact of Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) use on 90‐day postoperative outcomes and overall survival following partial nephrectomy (PN) for renal cell carcinoma (RCC), where type 2 diabetes mellitus (T2DM) is a common comorbidity.
Sam Kwon +7 more
wiley +1 more source
Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties. [PDF]
J Clin Invest, 2020 Knowland D +8 more
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Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy +4 more
wiley +1 more source
Survival of COVID-19 patients requires precise immune regulation: The hypothetical immunoprotective role of nicotinic agonists. [PDF]
Med Hypotheses, 2020 Allahverdi Khani M +3 more
europepmc +1 more source
Dynaflow ™ 48, a microfluidic chip solution for increasing throughput and data quality in patch-clamp-based drug screening [PDF]
, 2006 Ion channels are transm embrane proteins, found in virtually all cell types throughout the human body. Ion channels underlie neural communication, memory, behavior, every movement and heartbeat, and are as such prone to cause disease if malfunctioning.
Granfeldt, Daniel +4 more
core
Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan +7 more
wiley +1 more source
Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders
Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 346-363, February 2026.ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander +4 more
wiley +1 more source
Binding Interactions with the Complementary Subunit of Nicotinic Receptors [PDF]
, 2013 The agonist-binding site of nicotinic acetylcholine receptors (nAChRs) spans an interface between two subunits of the pentameric receptor. The principal component of this binding site is contributed by an α subunit, and it binds the cationic moiety of ...
Blum, Angela P. +4 more
core
Selective Alpha7 Nicotinic Receptor Agonist Increases Cardiac Function in Isolated Mouse Hearts by a Non-Nicotinic Mechanism [PDF]
, 2015 Cyrus Takahashi +5 more
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