Results 261 to 270 of about 489,131 (311)

Neuronal nicotinic acetylcholine receptor agonists

Expert Opinion on Therapeutic Patents, 2004
Nicotinic acetylcholine receptors (nAChRs) consist of five protein subunits surrounding a central ion channel.
TOMA, LUCIO, BARLOCCO Daniela, GELAIN Arianna   +2 more
openaire   +3 more sources

Pharmacotherapy for tobacco cessation: Nicotine agonists, antagonists, and partial agonists

Current Oncology Reports, 2007
Nicotine replacement therapies (NRT) were the main pharmacologic option for treatment of nicotine dependence until the early 1990s, when controlled clinical trials confirmed the efficacy of bupropion, the first treatment not based on nicotine. Varenicline, a partial agonist at nicotine receptors, gained US regulatory approval in 2006 for smoking ...
Maher, Karam-Hage, Paul M, Cinciripini
openaire   +2 more sources

Neuronal Nicotinic Acetylcholine Receptor Agonists

Current Pharmaceutical Design, 1996
In contrast to the considerable effort over many years to design agonists of the muscanmc acetylcholine receptor, until recently little attention has been directed towards agonists of the nicotinic family of acetylcholine receptors (NAChRs). Nevertheless, the structure and function of NAChRs has been a topic of intense research for several decades ...
Ian A. McDonald, Jean-Michel Vernier, Nicholas Cosford, Janis Corey-Naeve   +3 more
openaire   +1 more source

NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE

Clinical and Experimental Pharmacology and Physiology, 1990
SUMMARY1. The bronchomotor actions of three nicotinic cholinoceptor agonists were investigated in anaesthetized, mechanically ventilated cats. The agonists were administered intravenously after increasing baseline airways smooth muscle tone with an infusion of 5‐hydroxytryptamine.2.
D C, Thompson, R J, Altiere, L, Diamond
openaire   +2 more sources

Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist

Psychopharmacology, 1995
ABT-418, a novel cholinergic ligand, was reported to possess potent cognitive-enhancing and anxiolytic properties in animal models with reduced side effects (Decker et al. 1994; Garvey et al. 1994) suggesting selectivity of effects. In this study, the binding properties of ABT-418 to [3H]-nicotine sites were evaluated and its pharmacology investigated ...
M I, Damaj, K R, Creasy, S P, Welch, J A, Rosecrans, M D, Aceto, B R, Martin   +5 more
openaire   +2 more sources

Fluorescent Agonists for the Torpedo Nicotinic Acetylcholine Receptor

ChemBioChem, 2008
AbstractWe have synthesized a series of fluorescent acylcholine derivatives carrying different linkers that vary in length and structure and connect the acylcholine unit to the environment‐sensitive fluorophores 7‐(diethylamino)coumarin‐3‐carbonyl (DEAC) or N‐(7‐nitrobenz‐2‐oxa‐1,3‐diazol‐yl) (NBD).
Krieger, F., Mourot, A., Araoz, R., Kotzyba-Hibert, F., Molgó , J., Bamberg, E., Goeldner, M.   +6 more
openaire   +3 more sources

Effects of nicotinic agonists on the NMDA receptor

Brain Research, 1991
The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, were able to displace [3H]dizocilpine
E. Aizenman, Lian-Hong Tang, I. Reynolds
semanticscholar   +3 more sources

ChemInform Abstract: Nicotinic Acid Receptor Agonists

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P. Douglas Boatman, Jeremy G. Richman, Graeme Semple   +2 more
openaire   +1 more source

Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors.

Molecular Pharmacology, 1989
Isoarecolone methiodide (1-methyl-4-acetyl-1,2,3,6-tetrahydropyridine methiodide) was previously shown to be among the most potent agonists tested at the frog neuromuscular junction. Because nicotinic receptors from different sources vary in their selectivities, isoarecolone methiodide as well as 19 additional congeners, most of which were also ...
C E, Spivak, J A, Waters, R S, Aronstam
openaire   +2 more sources

7-Azaindole derivatives as potential partial nicotinic agonists

Bioorganic & Medicinal Chemistry Letters, 2008
We have investigated a series of 7-azaindoles as potential partial agonists of the alpha4beta2 nicotinic acetylcholine receptor (nAChR). Three series of 7-azaindole derivatives have been synthesized and evaluated for rat brain neuronal nicotinic receptor affinity and functional activity.
Axel R, Stoit, Arnold P, den Hartog, Harry, Mons, Sjoerd, van Schaik, Nynke, Barkhuijsen, Cees, Stroomer, Hein K A C, Coolen, Jan Hendrik, Reinders, Tiny J P, Adolfs, Martina, van der Neut, Hiskias, Keizer, Chris G, Kruse   +11 more
openaire   +2 more sources