Results 271 to 280 of about 33,509 (296)

Pharmacotherapy for tobacco cessation: Nicotine agonists, antagonists, and partial agonists

Current Oncology Reports, 2007
Nicotine replacement therapies (NRT) were the main pharmacologic option for treatment of nicotine dependence until the early 1990s, when controlled clinical trials confirmed the efficacy of bupropion, the first treatment not based on nicotine. Varenicline, a partial agonist at nicotine receptors, gained US regulatory approval in 2006 for smoking ...
Maher Karam-Hage, Paul M. Cinciripini
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The therapeutic potential of nicotine and nicotinic agonists for weight control

Expert Opinion on Investigational Drugs, 1999
Transdermal nicotine patches have been successfully introduced as a safe and powerful aid to smoking cessation; this has contributed to the rising interest in additional therapeutic applications for nicotine and synthetic nicotinic agonists. Nicotine and nicotinic agonists may have a therapeutic potential for a variety of disorders, including Alzheimer'
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Epibatidine, a novel nicotinic receptor agonist [PDF]

, 1994
It is speculated that nicotine receptor ligands might be of therapeutic benefit for the treatment of obesity, anxiety, and memory loss. With the exception of nicotine, few selective high-affinity agents exist. (-)Epibatidine (1), isolated from Ecuadoran frogs, shows structural resemblence to (-)nicotine (2). Molecular modeling studies reveal that the N
T. McHugh, Marietta Piattoni-Kaplan, W. Glassco, Anthony W. Bannon, James P. Sullivan, D. M. Wypij, Michael W. Decker, Richard A. Glennon, J. McKay, Malgorzata Dukat, Stephen P. Arneric, Diana L. Donnelly-Roberts, May El, Billy R. Martin, T. Y. Shen, R. H. Loring, Murali Gopalakrishnan, K. R. Creasy, David J. Anderson, M. I. Damaj, X. Zhang, John A. Rosecrans, D. Dumas   +22 more
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Decamethonium is a partial agonist at the nicotinic acetylcholine receptor

Synapse, 1993
AbstractThe efficacy of decamethonium as an agonist at the nicotinic acetylcholine receptor has never been determined. Here, we demonstrate how patch clamp recording during rapid perfusion of agonists to outside‐out patches from BC3H‐1 cells can be used to provide an unambiguous estimate of the efficacy of decamethonium.
James P. Dilger, Yi Liu
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Nicotine effects on the activity of mice exposed prenatally to the nicotinic agonist anatoxin-a

Neurotoxicology and Teratology, 2005
Anatoxin-a is a nicotinic agonist produced by several genera of cyanobacteria, and has caused numerous deaths of wildlife, livestock and domestic animals world-wide. Several studies in the literature have shown that exposure of mice and rats to nicotine early in development alters its effects when the rodents are subsequently challenged with nicotine ...
Neil Chernoff, Jackie D. Farmer, Robert C. MacPhail, K.A. Jarema   +3 more
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Epibatidine, a potent analgetic and nicotinic agonist.

Molecular Pharmacology, 1994
Synthetic (+)- and (-)-epibatidine (an alkaloid originally characterized from frog skin) have potent analgetic activity in mice, using the hot-plate assay. The natural (+)-enantiomer, with an ED50 of about 1.5 micrograms/kg upon intraperitoneal injection, is about 2-fold more potent than the (-)-enantiomer.
B, Badio, J W, Daly
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Discriminative stimulus properties of the nicotinic agonist cytisine

Psychopharmacology, 1997
Cytisine binds with high affinity and specificity to neuronal nicotinic receptors but its physiological and behavioural effects are complex and differ from those of nicotine. The present study explores the behavioural aspects further by comparing the discriminative stimulus effects of cystisine with those of nicotine. Two groups of rats were trained to
Chris Chandler, I.P. Stolerman
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Fluorescent Agonists for the Torpedo Nicotinic Acetylcholine Receptor

ChemBioChem, 2008
AbstractWe have synthesized a series of fluorescent acylcholine derivatives carrying different linkers that vary in length and structure and connect the acylcholine unit to the environment‐sensitive fluorophores 7‐(diethylamino)coumarin‐3‐carbonyl (DEAC) or N‐(7‐nitrobenz‐2‐oxa‐1,3‐diazol‐yl) (NBD).
Jordi Molgó, Maurice Goeldner, Florian Krieger, Alexandre Mourot, Florence Kotzyba-Hibert, Ernst Bamberg, Rómulo Aráoz   +6 more
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Neuronal nicotinic acetylcholine receptor agonists

Expert Opinion on Therapeutic Patents, 2004
Nicotinic acetylcholine receptors (nAChRs) consist of five protein subunits surrounding a central ion channel.
TOMA, LUCIO, BARLOCCO Daniela, GELAIN Arianna   +2 more
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ABT — 418, a Novel Nicotinic Agonist

1994
With the plethora of receptor targets evolving as the result of nicotinic acetylcholine receptor (nAChR) cloning it is possible that new molecular entities selective for subtypes of nAChRs can be developed which are potentially free of the side effect liabilities associated with (-)-nicotine.
Jorge D. Brioni, M. W. Decke, Yvonne C. Martin, S. P. Amend, David J. Anderson, James R. Pauly, M. J. Buckley, J. T. Wasicak, A. D. Rodrigues, James R. Pauly, P. A. Pavlik, Michael W. Decker, David S. Garvey, M. Majchrzak, Diana L. Donnelly-Roberts, Stephen P. Arneric, Alyssa B. O'Neill, Mark W. Holladay, Richard J. Radek, Jerry J. Buccafusco, Alvin V. Terry, Scott F. Robinson, D. J. B. Kim, Peter Curzon, James P. Sullivan, K. C. Marsh, Susan Wonnacott, William J. Jackson, G. Wilkie, S C Quigley, Kennan C. Marsh, Michael Williams   +31 more
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