Results 271 to 280 of about 489,131 (311)

The therapeutic potential of nicotine and nicotinic agonists for weight control

Expert Opinion on Investigational Drugs, 1999
Transdermal nicotine patches have been successfully introduced as a safe and powerful aid to smoking cessation; this has contributed to the rising interest in additional therapeutic applications for nicotine and synthetic nicotinic agonists. Nicotine and nicotinic agonists may have a therapeutic potential for a variety of disorders, including Alzheimer'
openaire   +2 more sources

ABT — 418, a Novel Nicotinic Agonist

1994
With the plethora of receptor targets evolving as the result of nicotinic acetylcholine receptor (nAChR) cloning it is possible that new molecular entities selective for subtypes of nAChRs can be developed which are potentially free of the side effect liabilities associated with (-)-nicotine.
S. P. Arneric, M. Williams, M. W. Holladay, J. T. Wasicak, D. Donnelly-Roberts, D. J. Anderson, P. Pavlik, Y. C. Martin, D. S. Garvey, J. P. Sullivan, G. Wilkie, Susan Wonnacott, S. F. Robinson, James R. Pauly, M. W. Decke, J. D. Brioni, M. J. Buckley, P. Curzon, A. B. O’Neill, D. J. B. Kim, M. Majchrzak, K. Marsh, S. Quigley, A. D. Rodrigues, R. Radek, J. J. Buccafusco, W. J. Jackson, A. V. Terry, K. C. Marsh, M. W. Decker, S. P. Amend, J. R. Pauly   +31 more
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Discriminative stimulus properties of the nicotinic agonist cytisine

Psychopharmacology, 1997
Cytisine binds with high affinity and specificity to neuronal nicotinic receptors but its physiological and behavioural effects are complex and differ from those of nicotine. The present study explores the behavioural aspects further by comparing the discriminative stimulus effects of cystisine with those of nicotine. Two groups of rats were trained to
C J, Chandler, I P, Stolerman
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Epibatidine, a novel nicotinic receptor agonist

1994
It is speculated that nicotine receptor ligands might be of therapeutic benefit for the treatment of obesity, anxiety, and memory loss. With the exception of nicotine, few selective high-affinity agents exist. (-)Epibatidine (1), isolated from Ecuadoran frogs, shows structural resemblence to (-)nicotine (2). Molecular modeling studies reveal that the N
M. Dukat, D. Dumas, M. I. Damaj, W. Glassco, E. L. May, B. R. Martin, R. A. Glennon, D. M. Wypij, T. Y. Shen, K. R. Creasy, J. Rosecrans, J. P. Sullivan, A. W. Bannon, D. Donnelly-Roberts, D. J. Anderson, M. Piattoni-Kaplan, M. Gopalakrishnan, M. W. Decker, S. P. Arneric, R. Loring, T. McHugh, X. Zhang, J. McKay   +22 more
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Nicotinic Acid Receptor Agonists

Journal of Medicinal Chemistry, 2008
P Douglas, Boatman, Jeremy G, Richman, Graeme, Semple   +2 more
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Alpha-7 nicotinic agonist improves cognition in schizophrenia

Evidence Based Mental Health, 2016
ABSTRACT FROM: Keefe RS, Meltzer HA, Dgetluck N, et al . Randomized, double-blind, placebo-controlled study of encenicline, an α7 nicotinic acetylcholine receptor agonist, as a treatment for cognitive impairment in schizophrenia. Neuropsychopharmacology 2015;40:3053–60.
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The Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonists for the Treatment of the Cognitive Deficits Associated with Schizophrenia

CNS Drugs, 2015
C. Beinat, S. Banister, M. Herrera, Vivian Law, M. Kassiou   +4 more
semanticscholar   +1 more source

Agonist efficiency in a nicotinic receptor

Biophysical Journal, 2023
Dinesh Indurthi, Anthony Auerbach
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α7-nicotinic acetylcholine receptor agonists for cognitive enhancement in schizophrenia.

Annual Review of Medicine, 2014
R. Freedman
semanticscholar   +1 more source

Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists.

Ciba Foundation symposium, 1990
A. C. Collins, R. Bhat, J. Pauly, M. Marks   +3 more
semanticscholar   +1 more source