Results 101 to 110 of about 91,243 (276)

Schizophrenia is a TH2 dominant autoimmune disease possibly against acetylcholine receptors of CNS [PDF]

, 2012
Schizophrenia is a very common psychiatric disorder. However, its etiology and pathogenesis is still unknown. Current theory saying that neurotransmitter imbalance such as serotonin or dopamine only provides limited effectiveness in schizophrenia ...
Wanchung(Wan-Jiung) Hu
core   +1 more source

Multi‐Omics Insights Into the Role of Fructooligosaccharides Supplementation in Alleviating Salpingitis in Laying Hens

Animal Research and One Health, EarlyView.
Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song, Tao Duan, Rong Li, Xiaoqiu Wang, Fengdong Zhang, Jia Feng, Lin Qiao, Junlin Cheng, Lixian Chen, Aike Li, Yuna Min, Weiwei Wang   +11 more
wiley   +1 more source

CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease

Translational Psychiatry
Changes in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in Alzheimer’s Disease (AD). Protective and cognitive-enhancing roles for the nicotinic α5 subunit have been identified, but this gene has not been ...
Jonas Rybnicek, Yuxiao Chen, Milos Milic, Earvin S. Tio, JoAnne McLaurin, Timothy J. Hohman, Philip L. De Jager, Julie A. Schneider, Yanling Wang, David A. Bennett, Shreejoy Tripathy, Daniel Felsky, Evelyn K. Lambe   +12 more
doaj   +1 more source

Characterization of nAChRs in Nematostella vectensis supports neuronal and non-neuronal roles in the cnidarian–bilaterian common ancestor

EvoDevo, 2019
Background Nicotinic and muscarinic acetylcholine receptors likely evolved in the cnidarian–bilaterian common ancestor. Both receptor families are best known for their role at chemical synapses in bilaterian animals, but they also have described roles as
Dylan Z. Faltine-Gonzalez, Michael J. Layden   +1 more
doaj   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2.

PLoS ONE, 2014
Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis
Catherine A Vulfius, Igor E Kasheverov, Vladislav G Starkov, Alexey V Osipov, Tatyana V Andreeva, Sergey Yu Filkin, Elena V Gorbacheva, Maxim E Astashev, Victor I Tsetlin, Yuri N Utkin   +9 more
doaj   +1 more source

Dataset for the role of sustained attention in memory formation of transgenic mice for Alzheimer׳s disease

Data in Brief, 2016
Weekly submission of rats to active avoidance apparatus can be considered a neurostimulation strategy, once it can improve memory and can increase the density of receptors from different neurotransmitter systems in brain areas related to memory.
Natalia Mendes Schöwe, Eduardo Moreira de Oliveira, Hudson Sousa Buck, Tania Araujo Viel   +3 more
doaj   +1 more source

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations [PDF]

, 1992
We measured the permeability ratios (PX/PNa) of 3 wild-type, 1 hybrid, 2 subunit-deficient, and 22 mutant nicotinic receptors expressed in Xenopus oocytes for alkali metal and organic cations using shifts in the bi-ionic reversal potential of the ...
Cohen, Bruce N., Davidson, Norman, Labarca, Cesar, Lester, Henry A.   +3 more
core  

Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the WHO pharmacovigilance database

Arthritis &Rheumatology, Accepted Article.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportionality/clustering analysis from the WHO pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. [PDF]

, 2015
Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits.
D'Oyley, JM, Dhankher, P, Gill-Thind, JK, Millar, NS, Sheppard, TD   +4 more
core