Results 121 to 130 of about 55,979 (304)

Molecular pharmacology of an insect GABA receptor

, 2010
Cys-loop receptors are ligand-gated ion channels that are involved in fast synaptic neurotransmission in the central and peripheral nervous system. The Cys-loop receptor RDL (‘resistant to dieldrin’) is a GABA-gated chloride channel from Drosophila ...

core   +1 more source

Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits

Journal of Adolescence, EarlyView.
ABSTRACT Introduction While adverse childhood experiences (ACEs) are robust risk factors for adolescent substance use, the prospective neurocognitive pathways linking both cumulative and specific adversities to substance use remain understudied. This study tested a vulnerability model by examining whether executive function (EF) deficits mediate the ...
Mahsa P. Yousefkhani, Xiafei Wang, Sara A. Vasilenko   +2 more
wiley   +1 more source

Modulation of Synaptic Amplification in Sympathetic Ganglia [PDF]

, 2013
The purpose of this dissertation was to assess synaptic integration in neurons from the rat superior cervical ganglion (SCG) using complex temporal patterns of virtual synaptic activity that mimic in vivo conditions.
Springer, Mitchell
core  

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice

, 2012
Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD.
Auburger, G, Gispert, Suzana, Stephanie J Cragg, Suzana Gispert, Auburger Georg, Cragg, Stephanie J., Cragg Stephanie J., Georg Auburger, Gispert, S, Platt Nicola J., Auburger, Georg, Platt, NJ, Cragg, Stephanie, Nicola J Platt, Gispert Suzana, Platt, Nicola J.   +15 more
core   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

The role of nicotinic receptors in alcohol consumption. [PDF]

Pharmacol Res, 2023
Kamens HM, Flarend G, Horton WJ.
europepmc   +1 more source

Presynaptic Nicotinic Receptors Facilitate Monoaminergic Transmission

, 1998
Nicotine is reported to increase arousal and attention and to elevate mood, effects that are most often associated with changes in the function of monoaminergic neuromodulatory systems (Feldman et al., 1997).
Robert W. Greene, Robert W. McCarley, Donald G. Rainnie, Xiangyang Li   +3 more
core   +1 more source

Impact of severe periodontitis and diabetes mellitus on recurrent cardiovascular outcomes

Journal of Periodontology, EarlyView.
Abstract Background This post hoc analysis of the Periodontitis and Coronary Heart Disease study (ClinicalTrials.gov Identifier: NCT01045070) aimed to determine the association between diabetes and recurrent cardiovascular events (CVEs) in patients with cardiovascular disease (CVD) and severe periodontitis.
Stefan Reichert, Axel Schlitt, Selina Rehm, Susanne Schulz   +3 more
wiley   +1 more source

Mapping the subgingival HerBiome and HisBiome over the human healthspan

Journal of Periodontology, EarlyView.
Abstract Background Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age‐related oral and systemic diseases. Methods Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years.
Rahul Nikam, Kazune Pax, Michelle Lee‐Scott Beverly, Purnima S. Kumar   +3 more
wiley   +1 more source