Results 141 to 150 of about 597,674 (298)

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Cigarette Smoke Exposure Attenuates T2R‐Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Tobacco use is associated with worse outcomes in head and neck squamous cell carcinoma (HNSCC). Bitter taste receptor (T2R) activation induces apoptosis via calcium‐dependent signaling, and higher T2R expression correlates with increased survival in HNSCC.
Kyle Polen, Sarah Sywanycz, Gavin Turner, Brianna L. Hill, Lily Huang, Zoey A. Miller, Casey Hanna, Lovely Raghav, Devraj Basu, Robert J. Lee, Ryan M. Carey   +10 more
wiley   +1 more source

Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids. [PDF]

PLoS Genet, 2023
Komori Y, Takayama K, Okamoto N, Kamiya M, Koizumi W, Ihara M, Misawa D, Kamiya K, Yoshinari Y, Seike K, Kondo S, Tanimoto H, Niwa R, Sattelle DB, Matsuda K.   +14 more
europepmc   +1 more source

Nicotinic acetylcholine receptors

Scholarpedia, 2008
Pierre-Jean Corringer, Jean-Pierre Changeux   +1 more
openaire   +1 more source

Anion Conducting States of Excitatory Amino Acid Transporters [PDF]

, 2013
Excitatory amino acid transporters (EAATs) are secondary active, electrogenic transporters which translocate L-glutamate (glu) against its concentration gradient using the co-transport of 3 Na+, 1 H+, and the counter-transport of 1 K+ ion.
Divito, Christopher B.
core  

Comparison of Healthcare Utilization Before Diagnosis Between Non‐Advanced and Advanced Lung Cancer Patients: A Study Among 72,851 Cases in Germany

International Journal of Cancer, EarlyView.
ABSTRACT There is no study from Germany on the association between stage of lung cancer (LC) and patient characteristics. We aimed to compare advanced versus non‐advanced LC cases regarding indicators of healthcare utilization. Using claims data covering 20% of the German population, we included LC patients diagnosed between 2013 and 2019.
Josephine Küsel‐Kanbach, Oliver Riedel, Ulrike Haug   +2 more
wiley   +1 more source

Mechanisms of modulation of nicotinic acetylcholine receptors [PDF]

, 2016
Dissertation (Ph.D.) University of Alaska Fairbanks, 2016Inappropriate expression of nicotinic acetylcholine receptors in the central nervous system is associated with nicotine addiction, Alzheimer's disease, Parkinson's disease and other disorders ...
Demmerly, Arianna L.
core  

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Taking Jobs and Doing Harm

Journal of Applied Philosophy, EarlyView.
ABSTRACT In popular discourse and in the philosophical literature there is almost no reflection on the morality of doing harm in the context of doing one's job. To the contrary, workers are valorised simply for having a job, and typically individual workers are spared from blame, even when they cause significant harm as part of their job.
Theron Pummer, Benjamin Sachs‐Cobbe
wiley   +1 more source

Nicotinic receptors as SARS-CoV-2 spike co-receptors? [PDF]

Med Hypotheses, 2022
Dormoy V, Perotin JM, Gosset P, Maskos U, Polette M, Deslée G.   +5 more
europepmc   +1 more source