Results 151 to 160 of about 55,979 (304)

Rigid analogs of DMPP as probes for the nicotinic receptors

, 2005
Chemical manipulation of the nicotinic DMPP, endowed with modest activity on the central receptors, definitely improved its affinity and pharmacokinetic properties.
MARTINI E, MARTELLI C, ROMANELLI MN, VARANI, Katia, GUANDALINI L   +4 more
core   +1 more source

Selective Excitation of Subtypes of Neocortical Interneurons by Nicotinic Receptors

, 1999
The cellular mechanisms by which neuronal nicotinic cholinergic receptors influence many aspects of physiology and pathology in the neocortex remain primarily unknown.
Bertrand Lambolez, Bruno Cauli, Keisuke Tsuzuki, Jean Rossier, Etienne Audinat, James T. Porter   +5 more
core   +1 more source

Prioritizing Modifiable Risk Factors for Cardiovascular Diseases in Adults With Hypertension: A Prospective Cohort Study

Med Research, EarlyView.
This study examined the relative contributions of modifiable risk factors to cardiovascular diseases in adults with hypertension. More favorable risk factor profiles were consistently associated with lower risks across all outcomes. Beyond blood pressure, nicotine exposure showed comparatively larger population attributable fractions.
Shengtao Wei, Dashan Zheng, Lan Chen, Zitong Zhuang, Zihan Lin, Junguo Zhang, Peng Hu, Zijun Yang, Zhen‐He Huang, Bing Zhang, Hualiang Lin   +10 more
wiley   +1 more source

A role for α7 nicotinic receptors in promoting stress resilience in female mice. [PDF]

Neuropsychopharmacology, 2022
Hoffman AF.
europepmc   +1 more source

The activation mechanism of alpha 1 homomeric glycine receptors

, 2004
The glycine receptor mediates fast synaptic inhibition in the spinal cord and brainstem. Its activation mechanism is not known, despite the physiological importance of this receptor and the fact that it can serve as a prototype for other homopentameric ...
Sivilotti, LG, Colquhoun, D, Groot-Kormelink, PJ, Beato, M   +3 more
core  

Associations Between Cumulative Head Trauma and Self‐Reported Parkinsonism and Parkinson's Disease in Former Soccer Players

Movement Disorders, EarlyView.
Abstract Background Cumulative head trauma, encompassing repetitive head impacts (RHI) and traumatic brain injury (TBI), has been associated with later‐life neurodegenerative disease. Studies on parkinsonism/Parkinson's disease (PD) have evaluated RHI and TBI in isolation, yielding mixed results.
Annalise E. Miner, Matthew J. Kmiecik, Niharika Namburi, Nathaniel Dunckley, Charles H. Adler, Erika D. Driver‐Dunckley, Christopher J. Nowinski, Joshua Gottesman, Yorghos Tripodis, Robert A. Stern, Ann C. McKee, Thor D. Stein, Jesse Mez, Farren B.S. Briggs, Michael L. Alosco   +14 more
wiley   +1 more source

α3β4 Acetylcholine Nicotinic Receptors Are Components of the Secretory Machinery Clusters in Chromaffin Cells. [PDF]

Int J Mol Sci, 2022
Villanueva J, Criado M, Giménez-Molina Y, González-Vélez V, Gil A, Gutiérrez LM.   +5 more
europepmc   +1 more source

A new specific neuronal modulatory effect of nicotine: the functional cross talk between nicotinic and glutamate receptors

, 2014
We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting the co-localization and the functional interaction between nicotinic acetylcholine receptors and some glutamatergic receptors.
Mario Marchi, Anna Pittaluga, Massimo Grilli
core  

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Structural Insights into the Role of β3 nAChR Subunit in the Activation of Nicotinic Receptors. [PDF]

Molecules, 2022
Giastas P, Papakyriakou A, Tsafaras G, Tzartos SJ, Zouridakis M.   +4 more
europepmc   +1 more source