Results 121 to 130 of about 57,977 (335)

Nicotinic acetylcholine receptors and cancer

Biomedical Reports, 2016
Nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChRs), which are membrane ligand-gated cation channels. nAChRs activation can be triggered by the neurotransmitter Ach, or certain other biological compounds, such as ...
Xianguang Meng, Haiyan Song, Ningning Dang   +2 more
openaire   +4 more sources

Conceptual and organizational barriers to quantitative systems pharmacology modeling of pathophysiological systemic drug hypotheses

, 2022
CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1556-1559, December 2022.
Ronald Gieschke, Robert Carr
wiley   +1 more source

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

eLife, 2018
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors.
Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jérémie Naudé, Thibaut d'Izarny-Gargas, Stéphanie Pons, Uwe Maskos, Dirk Trauner, Richard H Kramer, Philippe Faure, Alexandre Mourot   +12 more
doaj   +1 more source

PAK3 pathogenic variant associated with sleep‐related hypermotor epilepsy in a family with parental mosaicism

Epilepsia Open, EarlyView.
Abstract Protein‐activated kinases mediate spine morphogenesis and synaptic plasticity. PAK3 is part of the p21‐activated kinases (PAKs) family of Ras‐signaling serine/threonine kinases. Pathogenic variants in the X‐linked gene PAK3 have been described in patients with neurodevelopmental syndromes.
Antonio Gambardella, Yu‐Chi Liu, Mark F. Bennett, Timothy E. Green, John A. Damiano, Francesco Fortunato, Matthew J. Coleman, Jacqueline Cherfils, Jean‐Vianney Barnier, Jozef Gecz, Melanie Bahlo, Samuel F. Berkovic, Michael S. Hildebrand   +12 more
wiley   +1 more source

Personality Functioning in Inpatients With Eating Disorders: Association With Symptom Severity and Treatment Outcome

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Impairment in personality functioning (PF) has been linked to a number of mental disorders, including eating disorders (EDs). However, the precise relationship between PF and symptom severity, as well as the potential impact on outcome, remains unclear.
Sophia Heinzmann, Sonja Etzler, Armin Hartmann, Eva M. Klein, Stephan Herpertz, Magdalena Pape, Stanislav Heinzmann, Stephan Doering, Tobias Hofmann, Matthias Rose, Katrin Imbierowicz, Franziska Geiser, Antonie Bierling, Kerstin Weidner, Jörg Rademacher, Silke Michalek, Eva Morawa, Yesim Erim, Eva‐Maria Skoda, Martin Teufel, Eva Milena Johanne Peters, Johannes Kruse, Dirk von Boetticher, Christoph Herrmann‐Lingen, Mariel Noehre, Martina de Zwaan, Ulrike Dinger, Hans‐Christoph Friederich, Alexander Niecke, Christian Albus, Rüdiger Zwerenz, Manfred Beutel, Casper Roenneberg, Peter Henningsen, Barbara Stein, Christiane Waller, Karsten Hake, Carsten Spitzer, Andreas Stengel, Stephan Zipfel, Katja Weimer, Harald Gündel, Henrik Kessler, Derek Spieler, Claas Lahmann, Almut Zeeck   +45 more
wiley   +1 more source

The role of nicotinic receptors in alcohol consumption. [PDF]

Pharmacol Res, 2023
Kamens HM, Flarend G, Horton WJ.
europepmc   +1 more source

BLOCKADE OF DESENSITIZATION OF NICOTINIC RECEPTORS OF THE CAT ADRENAL MEDULLA BY CONCANAVALIN A [PDF]

, 1978
S. M. Kirpekar, J. C. Prat
openalex   +1 more source

Autoimmunity to neuronal nicotinic acetylcholine receptors

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in many and diverse cell types, participating in various functions of cells, tissues and systems.
Maria Pechlivanidou, Elpinickie Ninou, Katerina Karagiorgou, Aikaterini Tsantila, Renato Mantegazza, Andreetta Francesca, Raffaello Furlan, Leon Dudeck, Johann Steiner, John Tzartos, Socrates Tzartos   +10 more
doaj  

THE EFFECTS OF ANTICHOLINESTERASES ON SYNAPTIC TRANSMISSION THROUGH NICOTINIC AND MUSCARINIC RECEPTORS IN RAT SYMPATHETIC GANGLIA in vivo [PDF]

, 1974
G.M. Drew, Guy Leach
openalex   +1 more source

Influence of nicotine and alcohol on sleep latency: the reward-attention circuit model [PDF]

arXiv, 2019
We previously developed a neurocomputational model called the reward-attention circuit, which has been used to investigate the separate effects of nicotine and alcohol on attention focus. The model is based on known circuits linking midbrain dopaminergic neurons to the thalamocortical loop and is sufficiently versatile to capture diverse phenomena.
arxiv