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The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Trends in Pharmacological Sciences, 1990Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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Nicotinic receptors and stages of nicotine dependence.
Journal of psychopharmacology (Oxford, England), 2010Smoking is one of the leading causes of preventable death, where nicotine has been identified as the primary addictive constituent of tobacco. Consequently, there have been extensive investigations into the neuroadaptations that occur as nicotine dependence develops, where numerous neurological systems have been implicated. The focus of this review was
K A, Brennan +3 more
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Neuronal Nicotinic Acetylcholine Receptors
1996Studies of the structure and function of neuronal nicotinic acetylcholine receptors (AChRs) evolved out of studies of muscle AChRs. This review will begin with a brief summary of muscle type AChRs because they are the archetype for studies of neuronal nicotinic AChRs in particular and ligand-gated ion channels in general.
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Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
Current Neuropharmacology, 2018Cecilia Gotti +2 more
exaly
Nicotinic and Opioid Receptor Interactions in Nicotine Addiction
Molecular Interventions, 2006openaire +2 more sources
The role of nicotinic acetylcholine receptors in the mechanisms of anesthesia
Brain Research Bulletin, 2002EDÖMER Tassonyi, Daniel Bertrand
exaly
Central Nicotinic Receptors: Structure, Function, Ligands, and Therapeutic Potential
ChemMedChem, 2007Elisabetta Martini, Paola Gratteri
exaly