Results 151 to 160 of about 115,838,581 (186)

Niemann-Pick C1-Like 1 Inhibitors for Reducing Cholesterol Absorption

European Journal of Medicinal Chemistry, 2022
Cholesterol is an important component of cell membrane. However, elevated level of serum cholesterol is a key risk factor for heart disease. Niemann-Pick C1-Like 1 (NPC1L1) is the crucial target involving in cholesterol cellar uptake. Ezetimibe is the first, and only, NPC1L1 inhibitor approved for the treatment of hypercholesterolemia through ...
Renshuai Zhang, Dongming Xing, Jingsen Meng   +2 more
exaly   +3 more sources

Niemann–Pick C1 Like 1 (NPC1L1) an Intestinal Sterol Transporter

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2009
Niemann-Pick C1 Like 1 (NPC1L1) has been identified and characterized as an essential protein in the intestinal cholesterol absorption process. NPC1L1 localizes to the brush border membrane of absorptive enterocytes in the small intestine. Intestinal expression of NPC1L1 is down regulated by diets containing high levels of cholesterol.
Harry R Davis, Scott W Altmann
exaly   +3 more sources

Hepatic Niemann–Pick C1-like 1

Current Opinion in Lipidology, 2011
The discovery of Niemann-Pick C1-like 1 (NPC1L1) and ezetimibe, a drug that lowers intestinal cholesterol absorption, has contributed to the recognition of the intestine as an important organ in whole-body cholesterol homeostasis. Unfortunately, the majority of the studies on NPC1L1 have been conducted in rodent models, which, in contrast to humans, do
Camilla, Pramfalk, Zhao-Yan, Jiang, Paolo, Parini   +2 more
openaire   +2 more sources

Niemann–Pick C1-Like 1 and cholesterol uptake

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein responsible for dietary cholesterol and biliary cholesterol absorption. Consistent with its functions, NPC1L1 distributes on the brush border membrane of enterocytes and the canalicular membrane of hepatocytes in humans. As the molecular target of ezetimibe, a hypocholesterolemic drug,
Li-Juan, Wang, Bao-Liang, Song
openaire   +2 more sources

Niemann‐Pick C1‐like 1 Promotes Intestinal Absorption of Siphonaxanthin

Lipids, 2019
AbstractSiphonaxanthin is a carotenoid found in certain green algae, and its promising beneficial properties, such as its anti‐obesity effect, have recently been demonstrated. However, there is little information about the molecular mechanisms underlying intestinal absorption of siphonaxanthin. In this study, we aimed to elucidate how siphonaxanthin is
Yuki Manabe, Misato Ichihara, Kyoko Fukuda, Nami Tomonaga, Zhuo‐Si Li, Yoshihide Yamanashi, Hiroshi Suzuki, Tappei Takada, Michinori Matsuo, Tatsuya Sugawara   +9 more
openaire   +2 more sources

Niemann-Pick C1-Like 1 Mediates α-Tocopherol Transport

Molecular Pharmacology, 2008
Dietary lipids and fat-soluble micronutrients are solubilized in mixed micelles and absorbed in the small intestine. Based on an assumption that cholesterol and other fat-soluble molecules share a number of transport mechanisms and the fact that Niemann-Pick C1-like 1 (NPC1L1) is critical for intestinal cholesterol absorption, we hypothesized that some
Kazuya, Narushima, Tappei, Takada, Yoshihide, Yamanashi, Hiroshi, Suzuki   +3 more
openaire   +2 more sources

Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption

Science, 2004
Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease. The molecular mechanism of sterol uptake from the lumen of the small intestine is poorly defined.
Scott W, Altmann, Harry R, Davis, Li-Ji, Zhu, Xiaorui, Yao, Lizbeth M, Hoos, Glen, Tetzloff, Sai Prasad N, Iyer, Maureen, Maguire, Andrei, Golovko, Ming, Zeng, Luquan, Wang, Nicholas, Murgolo, Michael P, Graziano   +12 more
openaire   +2 more sources

The structure and function of Niemann–Pick C1-like 1 protein

Current Opinion in Lipidology, 2008
Intestinal absorption and biliary excretion of cholesterol represent two major pathways by which the body regulates cholesterol homeostasis. Niemann-Pick C1-like 1 (NPC1L1) is a polytopic transmembrane protein containing a sterol-sensing domain of unknown function.
openaire   +2 more sources

Cholesterol homeostasis by the intestine: Lessons from Niemann-Pick C1 like 1 (NPC1L1)

Atherosclerosis Supplements, 2008
Ezetimibe is a selective cholesterol absorption inhibitor, which potently inhibits the uptake and absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble vitamins, triglycerides or bile acids.
Harry R, Davis, Federica, Basso, Lizbeth M, Hoos, Glen, Tetzloff, Sean M, Lally, Scott W, Altmann   +5 more
openaire   +2 more sources

Expression of the Niemann-Pick C1-like 1 Protein in Gastric Cancer

Anticancer Research
5-Fluorouracil (5-FU) plays a major role in the treatment of gastric cancer (GC), and overcoming resistance to this drug remains a critical challenge. This study aimed to identify genes associated with resistance to 5-FU in GC.Gene expression levels were analyzed in 5-FU-resistant MKN-45/F2R cells compared to the parental MKN-45 strain before and after
Takeharu, Imai, Manabu, Futamura, Ryutaro, Mori, Itaru, Yasufuku, Toshiyuki, Tanahashi, Chiemi, Saigo, Tamotsu, Takeuchi, Nobuhisa, Matsuhashi   +7 more
openaire   +2 more sources