Results 111 to 120 of about 15,838 (212)

Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice

Journal of Lipid Research, 2003
Niemann-Pick type C1 disease (NPC1) is an inherited neurovisceral lipid storage disorder, hallmarked by the intracellular accumulation of unesterified cholesterol and glycolipids in endocytic organelles. Cells acquire cholesterol through exogenous uptake
Patrick C. Reid, Shigeki Sugii, Ta-Yuan Chang   +2 more
doaj   +1 more source

An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor. [PDF]

Cell Commun Signal, 2023
Ahmad I, Fatemi SN, Ghaheri M, Rezvani A, Khezri DA, Natami M, Yasamineh S, Gholizadeh O, Bahmanyar Z.   +8 more
europepmc   +1 more source

The metabolism of APP protein in lysosomal storage disorders [PDF]

, 2009
Nedavna istraživanja su pokazala da povišena razina kolesterola može mijenjati cijepanje prekursora proteina amiloid-beta (APP) i utjecati na nakupljanje peptida amiloid-beta (Aβ), glavne patološke značajke Alzheimerove bolesti (AB).
Posavec, Melanija
core   +1 more source

Uncovering the Causal Link Between Obesity‐Associated Genes and Multiple Sclerosis: A Systematic Literature Review

Brain and Behavior
Background: Multiple sclerosis (MS) is a multifaceted neurodegenerative disorder influenced by genetics and lifestyle. This systematic literature review investigates the role of six obesity‐associated genes, including fat mass and obesity‐associated (FTO)
Ali Jafari, Sara Khoshdooz, Melika Arab Bafrani, Farnush Bakhshimoghaddam, Hamid Abbasi, Saeid Doaei   +5 more
doaj   +1 more source

Optimization of systemic AAV9 gene therapy in Niemann–Pick disease, type C1 mice

Life Science Alliance
Systemic AAV9-h NPC1 gene therapy in null Npc1 m1N mice at higher doses or with earlier administration and treatment of hypomorphic Npc1 I1061T mice delays disease progression and increases lifespan. Niemann–Pick disease, type C1 (NPC1), is a rare, fatal
Avani V Mylvara, Alana L Gibson, Tansy Gu, Cristin D Davidson, Arturo A Incao, Katerina Melnyk, Susan R Gembic, Dominick Pierre-Jacques, Stephanie M Cologna, Charles P Venditti, Forbes D Porter, William J Pavan   +11 more
doaj   +1 more source

Ezetimibe Induces Paraptosis through Niemann-Pick C1-like 1 Inhibition of Mammalian-Target-of-Rapamycin Signaling in Hepatocellular Carcinoma Cells. [PDF]

Genes (Basel), 2023
Yin Y, Wu C, Zhou Y, Zhang M, Mai S, Chen M, Wang HY.   +6 more
europepmc   +1 more source

Molecular Characterisation of Niemann Pick Type C1 Protein

, 2014
Niemann-Pick disease type C (NPC) is a fatal neurodegenerative disorder characterised by accumulation of free cholesterol and glycosphingolipids in the late endosome (LE) and lysosome (Ly). Loss-of-function mutations in the NPC1 gene account for as high as 95% incidence among all NPC cases.
openaire   +2 more sources

Sterol-binding proteins in late endosomes : Regulation of endosome motility and lipid metabolism [PDF]

, 2011
Despite its bad reputation in the mass media, cholesterol is an indispensable constituent of cellular membranes and vertebrate life. It is, however, also potentially lethal as it may accumulate in the arterial intima causing atherosclerosis or elsewhere ...
Uronen, Riikka-Liisa
core  

Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake. [PDF]

Molecules, 2022
Zeng J, Liu W, Liang B, Shi L, Yang S, Meng J, Chang J, Hu X, Zhang R, Xing D.   +9 more
europepmc   +1 more source

Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia [PDF]

, 2017
Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke.
AlSulaiman, Wafa
core