Results 121 to 130 of about 15,838 (212)

Genetic Association of Lipids and Lipid‐Lowering Drug Target Genes With Atopic Dermatitis: A Drug Target Mendelian Randomization Study

Health Science Reports
Background and Aims Several observational studies have reported inconsistent associations between dyslipidaemia, stains use and atopic dermatitis (AD).
Min Luo, Jinger Lin, Qianwei Zhuo, Lihang Lin, Yue Han   +4 more
doaj   +1 more source

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy. [PDF]

, 2020
Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell immunotherapy.
Hardman, Clayton, Ho, Stephen, Luu-Nguyen, Quang, Marsden, Matthew D, Shimizu, Akira, Sloane, Jack L, Soliman, Mohamed SA, Wender, Paul A, Zack, Jerome A   +8 more
core  

Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes

European Journal of Cell Biology
The ongoing phagocytic activity of macrophages necessitates an extraordinary capacity to digest and resolve incoming material. While the initial steps leading to the formation of a terminal phagolysosome are well studied, much less is known about the ...
Dante Barreda, Sergio Grinstein, Spencer A. Freeman   +2 more
doaj   +1 more source

Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria. [PDF]

Nat Commun, 2022
Weng Y, Shepherd D, Liu Y, Krishnan N, Robertson BD, Platt N, Larrouy-Maumus G, Platt FM.   +7 more
europepmc   +1 more source

Hydroxyurea ameliorates atherosclerosis in ApoE^-/- mice by potentially modulating Niemann-Pick C1-like 1 protein through the gut microbiota. [PDF]

Theranostics, 2022
Yang XY, Yu H, Fu J, Guo HH, Han P, Ma SR, Pan LB, Zhang ZW, Xu H, Hu JC, Zhang HJ, Bu MM, Zhang XF, Yang W, Wang JY, Jin JY, Zhang HC, Li DR, Lu JY, Lin Y, Jiang JD, Tong Q, Wang Y.   +22 more
europepmc   +1 more source

Expression and prognostic significance of Niemann-Pick C1-Like 1 in colorectal cancer: a retrospective cohort study. [PDF]

Lipids Health Dis, 2021
Kwon RJ, Park EJ, Lee SY, Lee Y, Hwang C, Kim C, Cho YH.   +6 more
europepmc   +1 more source

Niemann-Pick disease type C1 (NPC1) [PDF]

Science-Business eXchange, 2011
openaire   +2 more sources

Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target. [PDF]

Antiviral Res, 2021
García-Dorival I, Cuesta-Geijo MÁ, Barrado-Gil L, Galindo I, Garaigorta U, Urquiza J, Puerto AD, Campillo NE, Martínez A, Gastaminza P, Gil C, Alonso C.   +11 more
europepmc   +1 more source

Niemann-Pick C1 (NPC1) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts. [PDF]

ACS Pharmacol Transl Sci, 2021
Cruz DL, Pipalia N, Mao S, Gadi D, Liu G, Grigalunas M, O'Neill M, Quinn TR, Kipper A, Ekebergh A, Dimmling A, Gartner C, Melancon BJ, Wagner FF, Holson E, Helquist P, Wiest O, Maxfield FR.   +17 more
europepmc   +1 more source