Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy. [PDF]
, 2020 Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell immunotherapy.
Hardman, Clayton +8 more
core
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C [PDF]
, 2016 Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by the occurrence of visceral and neurological symptoms. At present, the molecular mechanisms causing neurodegeneration in this disease are unknown.
Bembi, Bruno +9 more
core +3 more sources
eLife, 2015 Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor-mediated uptake of LDL, and it also mediates cellular entry of Ebola virus.
Feiran Lu +6 more
doaj +1 more source
NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains
Journal of Lipid Research, 2018 Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular disease.
Wataru Nihei +12 more
doaj +1 more source
Origins of intestinal ABCA1-mediated HDL-cholesterol*
Journal of Lipid Research, 2008 The origins of cholesterol utilized by intestinal ABCA1 were investigated in the human intestinal cell line Caco-2. Influx of apical membrane cholesterol increases ABCA1 mRNA and mass, resulting in enhanced efflux of HDL-cholesterol.
F. Jeffrey Field +2 more
doaj +1 more source
Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression [PDF]
, 2010 Background: Curcumin is a polyphenol and the one of the principle curcuminoids of the spice turmeric. Its antioxidant, anti-cancer and anti-inflammatory effects have been intensively studied.
Dan Feng, Lena Ohlsson, Rui-Dong Duan
core +3 more sources
Journal of Lipid Research, 2008 The Niemann-Pick C1 (NPC1) protein regulates the transport of cholesterol from late endosomes/lysosomes to other compartments responsible for maintaining intracellular cholesterol homeostasis.
William S. Garver +3 more
doaj +1 more source
Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia [PDF]
, 2017 Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke.
AlSulaiman, Wafa
core
DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]
, 2018 Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping +21 more
core +2 more sources
Lipid raft abnormalities and subsequent protein trafficking effects in Niemann‐Pick type C1 (LB158)
The FASEB Journal, 2014 Many proteins and lipid components are organized within membrane microdomains, known as lipid rafts (LR). LR are cholesterol‐ and sphingolipid‐rich membranes resistant to non‐ionic detergents. In Niemann‐Pick type C1 (NPC1), a neurovisceral lysosomal storage disease, entrapment of cholesterol and sphingolipids occurs and may lead to alterations in LR ...
Eva‐Maria Kuech +5 more
openaire +1 more source