Results 121 to 130 of about 16,701 (225)

Silencing of the mutant SCAP allele accounts for restoration of a normal phenotype in CT60 cells selected for NPC1 expression

Journal of Lipid Research, 2005
The sterol regulatory element binding protein (SREBP)/SREBP cleavage-activating protein (SCAP) complex regulates the transcription of numerous genes involved in cellular cholesterol metabolism.
Jean Ann Maguire, Jerry W. Reagan, Jr.
doaj   +1 more source

Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway

Biomedicines
Background: Ezetimibe is used to treat cardiovascular disease as it blocks the sterol transporter Niemann-Pick C1-Like 1 (NPC1CL1) protein. However, recent evidence indicates that Ezetimibe inhibits several cancers indirectly by reducing circulating ...
Charmy Twala, Sibusiso Malindisa, Chamone Munnik, Selisha Sooklal, Monde Ntwasa   +4 more
doaj   +1 more source

Co-Expression of Niemann-Pick Type C1-Like1 (NPC1L1) with ACE2 Receptor Synergistically Enhances SARS-CoV-2 Entry and Fusion

Biomedicines
The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into human embryonic kidney (HEK293T) cells has been shown to be a cholesterol-rich, lipid raft-dependent process.
James Elste, Nicole Cast, Shalini Udawatte, Kabita Adhikari, Shannon Harger Payen, Subhash C. Verma, Deepak Shukla, Michelle Swanson-Mungerson, Vaibhav Tiwari   +8 more
doaj   +1 more source

The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane

Cell & Bioscience
The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol transporter located in the late endosome/lysosome (LE/Ly) that is involved in the mobilization of endocytosed cholesterol.
Piergiorgio La Rosa, Jessica Tiberi, Enrico Palermo, Roberta Stefanelli, S. Tiano, S. Canterini, Mirko Cortese, John Hiscott, M. Fiorenza   +8 more
semanticscholar   +1 more source

Kinetics and cellular site of glycolipid loading control [PDF]

, 2009
CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines.
Arora, Pooja, Baena, Andres, Baine, Ian, Bricard, Gabriel, Goldberg, Michael F., Im, Jin S., Jerud, Elliot S., Molano, Alberto, Ndonye, Rachel M., Venkataswamy, Manjunatha M., Yu, Karl O.A.   +10 more
core  

Niemann-Pick C1-Like Protein 1 [PDF]

, 2020
openaire   +1 more source

Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain.

Proceedings of the National Academy of Sciences of the United States of America, 2004
N. Ohgami, Dennis C. Ko, Matthew Thomas, M. Scott, C. Chang, Ta-Yuan Chang   +5 more
semanticscholar   +1 more source

Niemann-Pick C1-like protein (NPC1L1) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Niemann-Pick C1-like protein (NPC1L1) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.

Proceedings of the National Academy of Sciences of the United States of America, 1999
H. Watari, E. Blanchette‐Mackie, N. Dwyer, J. M. Glick, Shutish C. Patel, E. Neufeld, R. Brady, P. Pentchev, J. Strauss   +8 more
semanticscholar   +1 more source