Results 1 to 10 of about 82,496 (230)
A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine
Molecules, 2020 Proliposomes were used to improve the solubility and oral bioavailability of nifedipine. Nifedipine proliposomes were prepared by methanol injection-spray drying method.
Ye Bi +6 more
doaj +2 more sources
Effect of Gastric Fluid Volume on the in Vitro Dissolution and in Vivo Absorption of BCS Class II Drugs: A Case Study with Nifedipine [PDF]
AAPS Journal, 2016 Nifedipine is a BCS Class II drug used for treatment of hypertension and preterm labor. Large inter-patient variability in nifedipine absorption results in variable exposure among different patients.
Fadda, Hala M. +3 more
core +2 more sources
Drug Delivery, 2018 Nifedipine is completely absorbed by the gastrointestinal tract and its pharmacokinetics and metabolism may be influenced by microorganisms. If gut microbes are involved in the metabolism of nifedipine, plateau hypoxia may regulate the bioavailability ...
Juanhong Zhang +5 more
doaj +2 more sources
Frontiers in Endocrinology, 2019 Aging is associated with the development of various chronic diseases, in which both cardiovascular disorders and osteoarthritis are dominant. Currently, there is no effective treatment for osteoarthritis, whereas hypertension is often treated with L-type
Ilona Uzieliene +11 more
doaj +2 more sources
Nifedipine promotes the proliferation and migration of breast cancer cells.
PLoS ONE, 2014 Nifedipine is widely used as a calcium channel blocker (CCB) to treat angina and hypertension,but it is controversial with respect the risk of stimulation of cancers. In this study, we demonstrated that nifedipine promoted the proliferation and migration
Dong-Qing Guo +3 more
doaj +2 more sources
Nifedipine treatment reduces resting calcium concentration, oxidative and apoptotic gene expression, and improves muscle function in dystrophic mdx mice. [PDF]
PLoS ONE, 2013 Duchenne Muscular Dystrophy (DMD) is a recessive X-linked genetic disease, caused by mutations in the gene encoding dystrophin. DMD is characterized in humans and in mdx mice by a severe and progressive destruction of muscle fibers, inflammation ...
Francisco Altamirano +6 more
doaj +2 more sources
Deterioration of preexisting myoclonus following nifedipine use in parkinsonian syndrome: A case report [PDF]
eNeurologicalSciL-type calcium channel antagonists are uncommon causes of myoclonus, and the underlying mechanism remains unclear. Here, we report a case of parkinsonian syndrome with deterioration of preexisting myoclonus after nifedipine use.
Gohei Yamada +3 more
doaj +2 more sources
Development of Nifedipine Phytantriol-Based Cubosomes and In Vitro Simulation of Administration Through Pediatric Feeding Tubes [PDF]
PharmaceuticsBackground/Objectives: This study focused on developing an organic solvent-free formulation of phytantriol-based cubosomes for nifedipine delivery.
Lorena Almeida Lima +4 more
doaj +2 more sources
Hypertension in Pregnancy, 2017 Objective: To determine whether oral labetalol is associated with a shorter time to blood pressure control compared to oral extended release nifedipine for management of persistent postpartum hypertension.
Kathryn J. Sharma +2 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 Aim: It has been found that the co-administration of nifedipine with apatinib could cause exposure changes of nifedipine in vivo. But, whether this pharmacokinetic drug-drug interaction (DDI) between nifedipine and apatinib could enhance the ...
Hongrui Liu +8 more
doaj +1 more source