Results 141 to 150 of about 93,808 (329)
Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells. [PDF]
Platelet-activating factor (PAF) is a potent phospholipid mediator that exerts various pathophysiological effects by interacting with a G protein-coupled receptor.
Abood, Mary E.+4 more
core +1 more source
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier+3 more
wiley +1 more source
ABSTRACT Context Therapeutic drug monitoring (TDM) involves the collection of biological samples such as blood, plasma, urine, and saliva. The most commonly used biological matrix for the detection of drugs is either blood or plasma, as they are widely accepted by the regulatory authorities.
Arpita Sathyanarayanan+2 more
wiley +1 more source
Nifedipine therapy for Prinzmetal's angina.
James E. Muller, Stephen Gunther
openalex +1 more source
Effect of nifedipine on arterial hypoxaemia occurring after methacholine challenge in asthma. [PDF]
E Ballester+3 more
openalex +1 more source
Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms
A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum+4 more
wiley +1 more source
<p><strong>BACKGROUND</strong>: Preterm labor with intact membrane is responsible for approximately one-third of preterm births, which account for about 70-80% of all neonatal deaths among normally formed neonates. Premature delivery is
Ali Akbar Taherian, - Dehdar
doaj
Effect of Nifedipine on Frequency-Force Relationship in Isolated Dog Left Ventricular Muscle.
Shigetoshi Chiba+2 more
openalex +1 more source
Acute haemodynamic effects of nifedipine in patients with ventricular septal defect. [PDF]
S Berisha+4 more
openalex +1 more source
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye+5 more
wiley +1 more source