Results 121 to 130 of about 55,899 (242)

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Parasympathetic overdrive as a cause of overactive bladder in a high‐fat‐diet‐induced obesity mouse model

The Journal of Physiology, EarlyView.
Abstract figure legend Obesity and metabolic syndrome (MetS) are well‐known major risk factors for overactive bladder (OAB). Mechanisms underlying obesity‐/MetS‐associated OAB were explored using a high‐fat‐diet (HFD)‐induced obesity mouse model. HFD‐induced obesity/MetS mice developed an OAB phenotype characterized by enlarged non‐voiding contractions
Ayu Sugiura, Retsu Mitsui, Kyoko Miwa‐Nishimura, Hikaru Hashitani   +3 more
wiley   +1 more source

Comparison of efficacy and safety of nifedipine versus magnesium sulfate in treatment of preterm labor

Journal of Research in Medical Sciences, 2007
<p><strong>BACKGROUND</strong>: Preterm labor with intact membrane is responsible for approximately one-third of preterm births, which account for about 70-80% of all neonatal deaths among normally formed neonates. Premature delivery is
Ali Akbar Taherian, - Dehdar
doaj  

Development of Nifedipine Phytantriol-Based Cubosomes and In Vitro Simulation of Administration Through Pediatric Feeding Tubes

Pharmaceutics
Background/Objectives: This study focused on developing an organic solvent-free formulation of phytantriol-based cubosomes for nifedipine delivery.
Lorena Almeida Lima, Euler Eduardo Lisboa de Moura, Schauana Freitas Fraga, Renata Vidor Contri, Irene Clemes Külkamp-Guerreiro   +4 more
doaj   +1 more source

Magnitude, Preventability, and Determinants of Adverse Drug Reactions Among Hospitalized Obstetric Patients in Ethiopia: A Prospective Observational Study

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Adverse drug reactions (ADRs) are an important and potentially preventable cause of morbidity among hospitalized obstetric patients, with implications for both maternal and fetal safety, yet evidence from low‐resource settings remains limited.
Getachew Yitayew Tarekegn, Endalemaw Tsegaw, Fisseha Nigussie Dagnew, Sisay Sitotaw Anberbr, Tilaye Arega Moges, Samuel Berihun Dagnew, Samuel Agegnew Wondm, Tigabu Eskeziya Zerihun, Abel Temeche Kassaw, Desalegn Addis Mussie   +9 more
wiley   +1 more source

Resistant arterial hypertension in a patient with adrenal incidentaloma multiple steno-obstructive vascular lesions and antiphospholipid syndrome [PDF]

, 2015
Resistant hypertension is defined as above of blood pressure (≤ 140/90 mmHg) despite therapy with three or more antihypertensive drugs of different classes at maximum tolerable doses with one bling a diuretic.
CONCISTRE, ANTONIO, Gambale, G., IANNUCCI, Gino, Letizia, C., MARINELLI, CRISTIANO, PETRAMALA, LUIGI, Toma, G. De, Vincentis, G. De, ZACCARIA, Alvaro   +8 more
core  

Beyond Preeclampsia: Focal and Segmental Glomerulosclerosis Presenting as Nephrotic‐Range Proteinuria During Pregnancy, A Clinical Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Nephrotic‐range proteinuria during pregnancy is not always preeclampsia. This case illustrates a steroid‐responsive tip‐variant podocytopathy with normal angiogenic biomarkers (sFlt‐1/PlGF), supporting a non‐placental origin. Renal biopsy confirmed the diagnosis, while concurrent CMV infection may have acted as a potential immunologic trigger ...
Sierra Acuña Ximena Rosario, Camarena Pulido Eva Elizabet   +1 more
wiley   +1 more source

Nifedipine inhibits superoxide production induced by pulsatile stretch in human aortic endothelial cells [PDF]

, 2017
Dihydropiridine calcium channel blocker nifedipine restores nitric oxide-mediated vasodilation in human hypertension. The mechanims involved have not been fully characterized but may relate to endothelial protection.
Cosentino, Francesco, Lüscher, Thomas F., Volpe, Massimo   +2 more
core  

Antenatal diagnosis and maternal sirolimus treatment of polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Background Polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome is a rare autosomal recessive mTORopathy caused by biallelic STE20‐related kinase adaptor alpha (STRADA) loss‐of‐function variants. Animal models demonstrate that in utero mechanistic target of rapamycin (mTOR) inhibition can prevent cortical dyslamination ...
Christian Macedonia, Vincent J. Carson, D. Holmes Morton, Karin J. Blakemore, Mark I. Evans, Peter B. Crino   +5 more
wiley   +1 more source