Results 111 to 120 of about 55,899 (242)
The Journal of Physiology, EarlyView.Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier +3 more
wiley +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Context: Calcium channel blockers may theoretically exhibit relaxing effects not only on vascular smooth muscle but also on airway smooth muscle. Objective: To investigate possible effects of nifedipine on respiratory mechanics in the rat.
Alessandro Rubini +3 more
doaj +1 more source
Amyloid β alters vascular CaV1.2 channel spatiotemporal properties
The Journal of Physiology, EarlyView.Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor +5 more
wiley +1 more source
Nifedipine-induced Hyperglycaemia in an Infant: A Case Report
Nigerian Journal of PaediatricsSummary: This case report describes reversible hyperglycaemia in a severely ill six-month old Saudi boy treated with nifedipine for hypertension. Hyperglycaemia became manifest on the second day of treatment with nifedipine and was not dose-related ...
Jobran Al Qhtani +6 more
doaj
Effect of Calcium-Channel Blockade on the Aldosterone Response to Sodium Depletion and Potassium Loading in Man [PDF]
, 2017 Angiotensin II (Ang II) and potassium (K+) increase aldosterone (Aldo) production in vitro via Ca2+-dependent mechanisms. To determine the effects of Ca2+ antagonism in vivo, we examined the influence of nifedipine on the Aldo response to Na+ depletion ...
Favre, Laurent +2 more
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The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
A Validated Reversed-Phase HPLC Method for the Determination of Atorvastatin Calcium in Tablets [PDF]
, 2014 A Reversed-Phase Liquid Chromatographic (RP-LC) assay method was developed for the quantitative determination of atorvastatin calcium in the presence of its degradation products.
Ferello, L. +5 more
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Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
RUDN Journal of Medicine, 2010 In 55 cases of nifedipine usage it's pharmacokinetics and placenta permeability index (PPI) at 25 women of the main group were studied. Pharmacokinetical parameters showed that nifedipine usage at non-severe forms of preeclampsia with placental ...
F B Buranova
doaj
TOXICOLOGICAL STUDY OF MEBUDIPINE AND DIBUDINE, TWO NEW CALCIUMCHANNEL BLOCKERS, IN SACCHAROMYCES CERVISES AND ISOLATED RAT HEPATOCYTES CELLS INVITRO [PDF]
Mebudipine and Dibudipine are two new calcium antagosists used in laboratory animals. Toxicological testing were evaluated in cultured mouse cells in‐vitro and on growth yeast cells . It is shown that in these two system it is safe and no toxicological
بهلولی, شهاب +4 more
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