Results 111 to 120 of about 40,278 (255)

by the calcium channel blocker nifedipine

, 2014
Calcium channel blockers (CCB) are widely prescribed anti-hypertensive agents. The commonest side-effect, peripheral oedema, is attributed to a larger arterial than venous dilatation causing increased fluid filtration.
Niklas Telinius, de Leval, Marc, Sheyanth Mohanakumar, Pilegaard, Hans, Christian Aalkjaer, Nielsen, Jørn, Majgaard, Jens, Vibeke Hjortdal, Donna Briggs Boedtkjer, Kim, Sukhan, Marc de Leval, Hans Pilegaard, Telinius, Niklas, Pahle, Einar, Boedtkjer, Donna Briggs, Einar Pahle, Hjortdal, Vibeke, Jørn Nielsen, Jens Majgaard, Sukhan Kim, Aalkjaer, Christian, Mohanakumar, Sheyanth   +21 more
core   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Nifedipine in rat liver cirrhosis.

, 2016
Rat liver cirrhosis induced by CCl4+ethanol was employed to assess the effectiveness of nifedipine in reducing liver injury. Nifedipine reduced the severity of hepatocellular necrosis, significantly decreased Mallory bodies (p < 0.01), decreased ...

core  

Developmental mechanisms contributing to non‐linear firing dynamics in spinal motoneurons of the postnatal mouse

The Journal of Physiology, EarlyView.
Abstract figure legend. In this study, we describe how persistent inward currents (PICs) and nonlinear firing dynamics mature in slow‐type (green) and fast‐type (purple) motoneurons (MNs) during the second and third postnatal weeks of development in mice.
Simon A. Sharples, Gareth B. Miles
wiley   +1 more source

Nifedipine-induced Hyperglycaemia in an Infant: A Case Report

Nigerian Journal of Paediatrics
Summary: This case report describes reversible hyperglycaemia in a severely ill six-month old Saudi boy treated with nifedipine for hypertension. Hyperglycaemia became manifest on the second day of treatment with nifedipine and was not dose-related ...
Jobran Al Qhtani , Abdulla A Al Harthi , Yousef Katinni , Ahmed Al Barki , Sulaiman Al-Fifi , Asindi A Asindi , Saad Al Daama   +6 more
doaj  

Calcium antagonist nifedipine in treating pregnant women with arterial hypertension: pro and contra

Кардиоваскулярная терапия и профилактика, 2007
Calcium antagonist nifedipine, an antihypertensive and anti-anginal medication with vasodilating action, is widely used in cardiology practice. According to the recommendations on cardiovascular disease management in pregnancy, by the European Society of
N. K. Runikhina, B. Ya. Bart, O. N. Tkacheva   +2 more
doaj  

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1402-1413, November 2026.
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Alice Ke, Ernesto Callegari, Manthena V.S. Varma, Mayur K Ladumor, Chieko Muto, Richard J. Bertz, Hannah M. Jones, Vaishali Sahasrabudhe, Jing Liu   +8 more
wiley   +1 more source

Vibrotactile sensation and response to nifedipine dose titration in primary Raynaud's phenomenon

, 1989
The clinical response to two doses of sustained-release nifedipine was assessed during a double-blind, randomized, placebo-controlled trial in 22 patients with primary Raynaud's phenomenon.
Griffin, M. J., Hayward, R. A., Waller, D. G., Roath, O. S., Challenor, V. F.   +4 more
core   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Nifedipine repressed the cardiac differentiation profile.

, 2013
(A) Time course of the incidence of ES cell-derived contracting EBs generated in the absence (control) or presence of nifedipine or BayK8644. The mean±SEM of the percentage of EBs with contracting areas during differentiation is depicted.
Kurt Pfannkuche (30408), Bernd K. Fleischmann (107008), Daniela Malan (107018), Jürgen Hescheler (30413), Filomain Nguemo (107007), Michael Reppel (107026), Huamin Liang (30409), Tomo Šarić (107014), Manoj K. Gupta (107010), Wilhelm Bloch (45980), Heribert Schunkert (44257)   +10 more
core   +1 more source