Results 91 to 100 of about 55,899 (242)

Dialysis and Pregnancy: Optimizing Therapy for Best Maternal and Fetal Outcomes

Hemodialysis International, EarlyView.
ABSTRACT Pregnancy in women with end‐stage kidney disease (ESKD) requiring dialysis remains high risk, with significant maternal and fetal complications. While fertility rates are markedly reduced in this population, advances in dialysis care and obstetric management have led to increasing reports of successful pregnancies.
Shreepriya Mangalgi, Silvi Shah
wiley   +1 more source

In-situ freeze-drying - forming amorphous solids directly within capsules: An investigation of dissolution enhancement for a poorly soluble drug

Scientific Reports, 2017
Conversion into the amorphous form enhances the dissolution of poorly soluble drugs, however the barrier to market for medicines containing an amorphous drug is poor stability. The aim was to produce the amorphous form of a drug within a capsule, without
Abdulmalik Alqurshi, K. L. Andrew. Chan, Paul G. Royall   +2 more
doaj   +1 more source

Gingival and Periodontal Diseases and Conditions in Children and Adolescents: Consensus Report

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background The objectives of this Focused Workshop were to update the epidemiology, aetiology, risk factors, diagnosis and management of gingival and periodontal diseases and conditions in children and adolescents, and to explore the applicability of the 2018 Classification in children and adolescents.
Iain Chapple, Sotiria Gizani, Mariano Sanz, Dominique Declerck, Phoebus Madianos, Valerie Clerehugh, Monique Danser, Esti Davidovich, Janet Davies, Nikos Donos, Elisabeth Dursun, Elena Figuero, Filippo Graziani, Mervi Gursoy, Soren Jepsen, Clara Joseph, Moritz Kebschull, Norbert Kraemer, Tina Lambrinaki, Rodrigo López, David J. Manton, Joerg Meyle, Ana Molina, Lior Shapira, Cheryl Somani, Georgios Tsilingaridis, Svante Twetman, Nicola West, Biniyam Wondimu, Ferranti Wong, David Herrera   +30 more
wiley   +1 more source

Residual Pockets as an Endpoint on Periodontal Disease Progression in Supportive Periodontal Care

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate whether the number of residual probing pocket depths (PPDs) ≥ 5 mm predicts periodontitis progression in non‐smoking patients undergoing supportive periodontal care (SPC). Materials and Methods This retrospective study included 121 patients (3028 teeth), with Stage III/IV, Grade B/C periodontitis, who completed active ...
John Rong Hao Tay, Ethan Ng, Dawn Shu Fen Siow, Stella Jinran Zhan, Seyed Ehsan Saffari, Rodrigo López, Philip M. Preshaw   +6 more
wiley   +1 more source

Promotion of cutaneous penetration of nifedipine for nanoemulsion

Brazilian Journal of Pharmaceutical Sciences, 2017
This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index
Paula de Oliveira Arantes, Quesia Nery dos Santos, Zaida Maria Faria de Freitas, Alexandre dos Santos Pyrrho, Cristal Cerqueira-Coutinho, Ana Lucia Vazquez Villa, Elisabete Pereira dos Santos, Eduardo Ricci-Júnior   +7 more
doaj   +1 more source

The Determinants of Negotiated Pharmaceutical Prices

The Journal of Industrial Economics, EarlyView.
ABSTRACT We focus on the determinants of pharmaceutical drug prices. Using data from the Brazilian pharmaceutical market, we find large variations in drug prices across buyers, drug classes, and time periods. Our estimation results provide evidence that transaction‐specific determinants between buyers and sellers (e.g., transaction volume, buyer's ...
Ralph B. Siebert, Sebastian Linde, Brandon Norton   +2 more
wiley   +1 more source

Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]

, 2017
A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa, Kaufman, Daniel L, Middleton, Blake, Tian, Jide   +3 more
core   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes. [PDF]

, 2017
TRPV4 (transient receptor potential vanilloid 4) channels are Ca2+-permeable channels that play a key role in regulating vascular tone. In arterial myocytes, opening of TRPV4 channels creates local increases in Ca2+ influx, detectable optically as "TRPV4
Moreno, Claudia M, Navedo, Manuel F, O'Dwyer, Samantha, Santana, L Fernando, Sato, Daisuke, Tajada, Sendoa, Woods, Sean   +6 more
core   +3 more sources

Anti‐Proliferative Effects of Resveratrol on Gingival Fibroblasts Derived From Amlodipine‐Induced Gingival Overgrowth

Journal of Periodontal Research, EarlyView.
Resveratrol in repeated doses has been shown to suppress excessive cell proliferation without cytotoxic effects in amlodipine‐induced gingival hyperplasia, while not having a negative effect on mediators involved in tissue homeostasis in healthy cells, and at the same time, it reduces the expression of biomarkers involved in fibrosis processes ...
Bilkan Kara, Nuriye Işıl Saygun, Cansel Köse Özkan, Melis Özgül Slezovic, Muhittin Abdulkadir Serdar, Mualla Pınar Elçi, Alpdoğan Kantarci   +6 more
wiley   +1 more source