Results 101 to 110 of about 12,324 (206)

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

by the calcium channel blocker nifedipine

, 2014
Calcium channel blockers (CCB) are widely prescribed anti-hypertensive agents. The commonest side-effect, peripheral oedema, is attributed to a larger arterial than venous dilatation causing increased fluid filtration.
Niklas Telinius, de Leval, Marc, Sheyanth Mohanakumar, Pilegaard, Hans, Christian Aalkjaer, Nielsen, Jørn, Majgaard, Jens, Vibeke Hjortdal, Donna Briggs Boedtkjer, Kim, Sukhan, Marc de Leval, Hans Pilegaard, Telinius, Niklas, Pahle, Einar, Boedtkjer, Donna Briggs, Einar Pahle, Hjortdal, Vibeke, Jørn Nielsen, Jens Majgaard, Sukhan Kim, Aalkjaer, Christian, Mohanakumar, Sheyanth   +21 more
core   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Nifedipine repressed the cardiac differentiation profile.

, 2013
(A) Time course of the incidence of ES cell-derived contracting EBs generated in the absence (control) or presence of nifedipine or BayK8644. The mean±SEM of the percentage of EBs with contracting areas during differentiation is depicted.
Kurt Pfannkuche (30408), Bernd K. Fleischmann (107008), Daniela Malan (107018), Jürgen Hescheler (30413), Filomain Nguemo (107007), Michael Reppel (107026), Huamin Liang (30409), Tomo Šarić (107014), Manoj K. Gupta (107010), Wilhelm Bloch (45980), Heribert Schunkert (44257)   +10 more
core   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial

Hypertension in Pregnancy, 2017
Objective: To determine whether oral labetalol is associated with a shorter time to blood pressure control compared to oral extended release nifedipine for management of persistent postpartum hypertension.
Kathryn J. Sharma, Naomi Greene, Sarah J. Kilpatrick   +2 more
doaj   +1 more source

Efficacy of sodium channel blockers in treating myotonia is independent of action potential sodium current block

The Journal of Physiology, EarlyView.
Abstract figure legend Contrary to the prevailing view, the therapeutic efficacy of sodium channel blockers in myotonia does not depend on inhibition of the transient sodium current (NaT) responsible for action potentials. In a mouse model of myotonia congenita, effective concentrations of sodium channel blockers did not reduce NaT, but consistently ...
Phil Walker, Brent Foy, Xueyong Wang, Kaylee M. Pham, Jess Myers, Chris Dupont, Samantha Kohli, Adam S. Deardorff, Andrew A. Voss, Mark M. Rich   +9 more
wiley   +1 more source

The Effect of Topical Nifedipine in Treatment of Chronic Anal Fissure

Acta Medica Iranica, 2010
Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. Reduction of hypertonocity is a special treatment for fissure healing.
Farzaneh Golfam, Parisa Golfam, Alireza Khalaj, Sayed Saaid Sayed Mortaz   +3 more
doaj  

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source