Results 81 to 90 of about 40,278 (255)

A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals

British Journal of Pharmacology, EarlyView.
Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig, Yusuf C. Erdoğan, Benjamin Gottschalk, Michael Gruber, Andrea Groselj‐Strele, Sandra Burgstaller, Wolfgang F. Graier, Roland Malli   +7 more
wiley   +1 more source

Effectiveness of nifedipine in threatened preterm labor: a randomized trial

, 2018
Srisuda Songthamwat, Chatchanawadee Na Nan, Metha Songthamwat Department of Obstetrics and Gynecology, Udonthani Hospital, Udonthani, Thailand Objective: Threatened preterm labor is a condition in which regular uterine contractions occur at least 1 ...
Songthamwat M, Na Nan C, Songthamwat S
core  

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

Nifedipine Improves the Ketogenic Diet Effect on Insulin-Resistance-Induced Cognitive Dysfunction in Rats

Pharmaceuticals
Insulin resistance, induced by high fructose consumption, affects cognitive function negatively. Nifedipine may be suggested for neurological disorders.
Nancy M. Abdel-Kareem, Shimaa M. Elshazly, May A. Abd El Fattah, Afaf A. Aldahish, Sawsan A. Zaitone, Sahar K. Ali, Enas A. Abd El-Haleim   +6 more
doaj   +1 more source

Review of nifedipine GITS in the treatment of high risk patients with coronary artery disease and hypertension

, 2009
Amber Lundy, Nahla Lutfi, Cherylyn BeckeyVeterans Affairs Medical Center, Pharmacy Service, West Palm Beach, FL, USAAbstract: Nifedipine is a dihydropyridine calcium-channel blocker (CCB) introduced approximately 30 years ago for the prophylaxis of ...
Cherylyn Beckey, Nahla Lutfi, Amber Lundy   +2 more
core  

Diabetogenic Effect of Nifedipine

, 1989
This case report describes a 60-year-old diabetic patient whose daily insulin requirements increased by 30 percent following nifedipine administration. Glucagon and intravenous glucose tolerance tests were performed with and without nifedipine treatment,
Samuel N. Heyman, Ayelet Heyman, Itzchak Halperin   +2 more
core   +1 more source

High‐resolution pressure myography reveals pressure‐dependent local contractile and geometric dynamics in the renal pelvis and ureter

British Journal of Pharmacology, EarlyView.
Background and Purpose Coordinated peristalsis between the renal pelvis and ureter is critical for effective urine transport. However, intraluminal pressure impact on upper urinary tract (UUT) contractility and pharmacologic responsiveness remains poorly understood due to absence of suitable investigative methods.
Zhugang Chu, Qidi Zhai, Liming Lu, Maik Gollasch, Dmitry Tsvetkov, Rong Dong, S. R. Wayne Chen, Gang Fan, Guangheng Luo, Mario Kassmann   +9 more
wiley   +1 more source

Nifedipine Blocks Acth and Cortisol Release in Man

, 1989
1. The present study investigated the effect of prior administration of nifedipine on AVP‐induced ACTH release in seven normal volunteers. Three protocols were used: 20 mg oral nifedipine; 0.14 pressor units intramuscular (i.m.) per kg bodyweight aqueous
Vella, RD, Jackson, RV, Jackson, AJ, Grice, JE   +3 more
core   +1 more source

Efficacy of vaginal progesterone capsules in preventing preterm birth in women with subchorionic hematoma complicated by preterm labor or preterm prelabor rupture of membranes: A case–control observational study

International Journal of Gynecology &Obstetrics, EarlyView.
Eriko Yasuda, Yusuke Ueda, Taito Miyamoto, Yosuke Kawamura, Yoshitsugu Chigusa, Masaki Mandai, Haruta Mogami   +6 more
wiley   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source