Results 81 to 90 of about 27,204 (207)

Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability

open access: yesGlia, Volume 74, Issue 9, September 2026.
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios   +7 more
wiley   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2682-2692, August 2026.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup   +2 more
wiley   +1 more source

Nifedipine-induced Hyperglycaemia in an Infant: A Case Report

open access: yesNigerian Journal of Paediatrics
Summary: This case report describes reversible hyperglycaemia in a severely ill six-month old Saudi boy treated with nifedipine for hypertension. Hyperglycaemia became manifest on the second day of treatment with nifedipine and was not dose-related ...
Jobran Al Qhtani   +6 more
doaj  

Collagen‐Based Regenerative Therapy in a Critical Ischemic Diabetic Foot Ulcer: A Limb‐Salvaging Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT A 58‐year‐old man with diabetes, end‐stage renal disease, and severe peripheral arterial disease had a chronic ischemic foot ulcer refractory to one year of conventional therapy. Injectable collagen‐based regenerative therapy produced complete epithelialization within three months and durable limb salvage, even after a thermally induced ...
Ma'moun Qawasmeh   +4 more
wiley   +1 more source

Calcium antagonist nifedipine in treating pregnant women with arterial hypertension: pro and contra

open access: yesКардиоваскулярная терапия и профилактика, 2007
Calcium antagonist nifedipine, an antihypertensive and anti-anginal medication with vasodilating action, is widely used in cardiology practice. According to the recommendations on cardiovascular disease management in pregnancy, by the European Society of
N. K. Runikhina   +2 more
doaj  

Optimization of Newly Diagnosed Hypertension and Type II Diabetes Mellitus Before Myomectomy for Symptomatic Uterine Leiomyoma

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Severe but newly diagnosed cardiometabolic derangements do not preclude safe myomectomy. Structured, time‐limited optimization with multidisciplinary input allows surgery to proceed once cardiovascular risk is controlled, even if glycemic targets remain imperfectly met.
Orji Uguru Williams   +5 more
wiley   +1 more source

Labetalol, Nifedipine, and Methyldopa for the Management of Hypertensive Disorders in Pregnancy in Iran: A Cost‐Effectiveness Analysis

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Hypertensive disorders in pregnancy create major clinical and economic burdens on maternal health services, making evidence on efficient resource allocation and cost‐effectiveness essential for treatment decisions. However, no clear consensus exists on the most cost‐effective antihypertensive therapy in Iran.
Zahra Goudarzi   +2 more
wiley   +1 more source

The pharmacokinetical aspects of nifedipine in pregnant women with placental insufficiency in the phone preeclampsia

open access: yesRUDN Journal of Medicine, 2010
In 55 cases of nifedipine usage it's pharmacokinetics and placenta permeability index (PPI) at 25 women of the main group were studied. Pharmacokinetical parameters showed that nifedipine usage at non-severe forms of preeclampsia with placental ...
F B Buranova
doaj  

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak   +4 more
wiley   +1 more source

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