Results 81 to 90 of about 27,204 (207)
Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?
Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley +1 more source
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios +7 more
wiley +1 more source
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup +2 more
wiley +1 more source
Nifedipine-induced Hyperglycaemia in an Infant: A Case Report
Summary: This case report describes reversible hyperglycaemia in a severely ill six-month old Saudi boy treated with nifedipine for hypertension. Hyperglycaemia became manifest on the second day of treatment with nifedipine and was not dose-related ...
Jobran Al Qhtani +6 more
doaj
ABSTRACT A 58‐year‐old man with diabetes, end‐stage renal disease, and severe peripheral arterial disease had a chronic ischemic foot ulcer refractory to one year of conventional therapy. Injectable collagen‐based regenerative therapy produced complete epithelialization within three months and durable limb salvage, even after a thermally induced ...
Ma'moun Qawasmeh +4 more
wiley +1 more source
Calcium antagonist nifedipine in treating pregnant women with arterial hypertension: pro and contra
Calcium antagonist nifedipine, an antihypertensive and anti-anginal medication with vasodilating action, is widely used in cardiology practice. According to the recommendations on cardiovascular disease management in pregnancy, by the European Society of
N. K. Runikhina +2 more
doaj
ABSTRACT Severe but newly diagnosed cardiometabolic derangements do not preclude safe myomectomy. Structured, time‐limited optimization with multidisciplinary input allows surgery to proceed once cardiovascular risk is controlled, even if glycemic targets remain imperfectly met.
Orji Uguru Williams +5 more
wiley +1 more source
ABSTRACT Background and Aims Hypertensive disorders in pregnancy create major clinical and economic burdens on maternal health services, making evidence on efficient resource allocation and cost‐effectiveness essential for treatment decisions. However, no clear consensus exists on the most cost‐effective antihypertensive therapy in Iran.
Zahra Goudarzi +2 more
wiley +1 more source
In 55 cases of nifedipine usage it's pharmacokinetics and placenta permeability index (PPI) at 25 women of the main group were studied. Pharmacokinetical parameters showed that nifedipine usage at non-severe forms of preeclampsia with placental ...
F B Buranova
doaj
Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak +4 more
wiley +1 more source

